ai4nucleome

199 mods across 1 repository, 115 stars between them.

openclaw-spatialagent

145

ai4nucleome/BioMaster

Skill OpenCode

An agent that interprets spatial transcriptomics data to propose mechanistic hypotheses and analyze tissue organization.

not rated 115 3mo ago A 26 tokens

ai4nucleome/BioMaster

Skill OpenCode

Comprehensive AI-powered tumor microenvironment immune profiling integrating bulk deconvolution, single-cell analysis, and spatial transcriptomics for immunotherapy biomarker discovery.

not rated 115 3mo ago A 42 tokens

ai4nucleome/BioMaster

Skill OpenCode

Comprehensive immune repertoire analysis for T-cell and B-cell receptor sequencing data. Analyze TCR/BCR repertoires to assess clonality, diversity, V(D)J gene usage, CDR3 characteristics, convergence, and predict epitope specificity. Integrate with single-cell data for clonotype-phenotype associations. Use for…

not rated 115 3mo ago A 106 tokens

ai4nucleome/BioMaster

Skill OpenCode

Production-ready single-cell and expression matrix analysis using scanpy, anndata, and scipy. Performs scRNA-seq QC, normalization, PCA, UMAP, Leiden/Louvain clustering, differential expression (Wilcoxon, t-test, DESeq2), cell type annotation, per-cell-type statistical analysis, gene-expression correlation, batch…

not rated 115 3mo ago A 233 tokens

ai4nucleome/BioMaster

Skill OpenCode

Analyze spatial transcriptomics data to map gene expression in tissue architecture. Supports 10x Visium, MERFISH, seqFISH, Slide-seq, and imaging-based platforms. Performs spatial clustering, domain identification, cell-cell proximity analysis, spatial gene expression patterns, tissue architecture mapping, and…

not rated 115 3mo ago A 125 tokens

pathway-query-kegg

158

ai4nucleome/BioMaster

Skill OpenCode

Query the KEGG REST API for biological pathways, pathway gene lists, and gene info. Use when users ask about metabolic/signaling pathways, pathway genes, KEGG IDs, or gene-to-pathway mapping.

not rated 115 3mo ago A 48 tokens

plan-metagenomics

160

ai4nucleome/BioMaster

Skill OpenCode

Generate PLAN.yaml for detailed metagenomic analysis using R phyloseq-based functions.

not rated 115 3mo ago A 22 tokens

ai4nucleome/BioMaster

Skill OpenCode

Ligand-aware protein sequence design with LigandMPNN for small molecules, metals, cofactors, and DNA/RNA binding sites.

not rated 115 3mo ago A 35 tokens

proteomics-alphafold

163

ai4nucleome/BioMaster

Skill OpenCode

Validate protein designs using AlphaFold2 structure prediction: select backend, run prediction, extract confidence metrics (pLDDT, pTM, ipTM, PAE), assess quality against thresholds, and troubleshoot runtime errors.

not rated 115 3mo ago A 51 tokens

ai4nucleome/BioMaster

Skill OpenCode

Install and run RefHiC for reference-panel-guided Hi-C loop calling and TAD boundary annotation, including reference panel configuration, prediction, FDR-based selection, and output interpretation.

not rated 115 3mo ago A 47 tokens

registry

165

ai4nucleome/BioMaster

Skill OpenCode

Route user requests to domain, discipline, and candidate tumor scRNA-seq pipelines via SQLite pipeline routes.

not rated 115 3mo ago A 23 tokens

ai4nucleome/BioMaster

Skill OpenCode

Annotated matrices for single-cell genomics. Stores X with obs/var metadata, layers, embeddings (obsm/varm), graphs (obsp/varp), uns. Use for .h5ad/.zarr I/O, concatenation, scverse integration. For analysis use scanpy; for probabilistic models use scvi-tools.

not rated 115 3mo ago A 79 tokens

ai4nucleome/BioMaster

Skill OpenCode

GRN inference from expression via GRNBoost2 (gradient boosting) or GENIE3 (Random Forest). Load matrix, filter by TFs, infer TF-target-importance links, save network. Dask-parallelized to single-cell scale. Core SCENIC component.

not rated 115 3mo ago A 68 tokens

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