Skill OpenCode
An agent that interprets spatial transcriptomics data to propose mechanistic hypotheses and analyze tissue organization.
Skill OpenCode
An agent that interprets spatial transcriptomics data to propose mechanistic hypotheses and analyze tissue organization.
Skill OpenCode
Spatial analyst.
Skill OpenCode
Comprehensive AI-powered tumor microenvironment immune profiling integrating bulk deconvolution, single-cell analysis, and spatial transcriptomics for immunotherapy biomarker discovery.
Skill OpenCode
Comprehensive immune repertoire analysis for T-cell and B-cell receptor sequencing data. Analyze TCR/BCR repertoires to assess clonality, diversity, V(D)J gene usage, CDR3 characteristics, convergence, and predict epitope specificity. Integrate with single-cell data for clonotype-phenotype associations. Use for…
Skill OpenCode
Production-ready single-cell and expression matrix analysis using scanpy, anndata, and scipy. Performs scRNA-seq QC, normalization, PCA, UMAP, Leiden/Louvain clustering, differential expression (Wilcoxon, t-test, DESeq2), cell type annotation, per-cell-type statistical analysis, gene-expression correlation, batch…
Skill OpenCode
Analyze spatial transcriptomics data to map gene expression in tissue architecture. Supports 10x Visium, MERFISH, seqFISH, Slide-seq, and imaging-based platforms. Performs spatial clustering, domain identification, cell-cell proximity analysis, spatial gene expression patterns, tissue architecture mapping, and…
Skill OpenCode
Annotate scRNA-seq.
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Skill OpenCode
Query the KEGG REST API for biological pathways, pathway gene lists, and gene info. Use when users ask about metabolic/signaling pathways, pathway genes, KEGG IDs, or gene-to-pathway mapping.
Skill OpenCode
Define tumor scRNA-seq pipeline family and phase-1 demo target.
Skill OpenCode
Generate PLAN.yaml for detailed metagenomic analysis using R phyloseq-based functions.
Skill OpenCode
Generate PLAN.yaml for tumor scRNA-seq heterogeneity and trajectory analysis.
Skill OpenCode
Ligand-aware protein sequence design with LigandMPNN for small molecules, metals, cofactors, and DNA/RNA binding sites.
Skill OpenCode
Validate protein designs using AlphaFold2 structure prediction: select backend, run prediction, extract confidence metrics (pLDDT, pTM, ipTM, PAE), assess quality against thresholds, and troubleshoot runtime errors.
Skill OpenCode
Install and run RefHiC for reference-panel-guided Hi-C loop calling and TAD boundary annotation, including reference panel configuration, prediction, FDR-based selection, and output interpretation.
Skill OpenCode
Route user requests to domain, discipline, and candidate tumor scRNA-seq pipelines via SQLite pipeline routes.
Skill OpenCode
Generate structured tumor scRNA-seq analysis report.
Skill OpenCode
Annotated matrices for single-cell genomics. Stores X with obs/var metadata, layers, embeddings (obsm/varm), graphs (obsp/varp), uns. Use for .h5ad/.zarr I/O, concatenation, scverse integration. For analysis use scanpy; for probabilistic models use scvi-tools.
Skill OpenCode
GRN inference from expression via GRNBoost2 (gradient boosting) or GENIE3 (Random Forest). Load matrix, filter by TFs, infer TF-target-importance links, save network. Dask-parallelized to single-cell scale. Core SCENIC component.
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