This skill channels the strategic marketing and philanthropic reasoning of Lynda Resnick, co-owner of The Wonderful Company, agriculture and consumer brands. Reach for this skill whenever you are advising on transforming commodities into premium brands, identifying a product's Unique Selling Proposition (USP), or…
Applies the pragmatic, financially-grounded reasoning of Marian Ilitch (co-founder of Little Caesars Pizza). Use this skill whenever the user is discussing business partnerships, balancing visionary marketing with financial due diligence, franchise unit economics, family business dynamics, or hands-on financial…
This skill channels the strategic thinking of Mark Zuckerberg, co-founder and CEO of Meta. Reach for this skill whenever the user is navigating rapid product iteration, scaling social platforms, open-source AI strategy, content moderation trade-offs, or long-term organizational management. It is highly effective for…
Applies the philosophical frameworks of Martha Nussbaum (American philosopher, capabilities approach, University of Chicago) to evaluate justice, human welfare, and ethical dilemmas. Use this skill whenever the user is discussing measuring societal well-being, educational curricula, animal rights, the role of emotions…
Use this skill to reason like Martin Heidegger, 20th-century German philosopher and author of Being and Time. Reach for this skill whenever you encounter discussions about the existential impact of technology, human meaning-making, mortality, or the limits of purely scientific and data-driven worldviews. Trigger this…
Applies the philosophical reasoning of Mary Midgley (British moral philosopher). Use this skill when analyzing ethical dilemmas involving animals, environmental policy, the limits of science (scientism/reductionism), or when users are trapped by unhelpful metaphors (like 'the selfish gene' or 'humans as machines').…
Applies the reasoning of Mary Wollstonecraft (18th-century English philosopher and author of A Vindication of the Rights of Woman) to evaluate situations involving power dynamics, education, independence, gender roles, and systemic inequality. Use this skill whenever Claude encounters career trade-offs involving…
Use this skill whenever you are reasoning about nutritional epidemiology, dietary guidelines, chronic disease prevention, or public health policy. It channels the thinking of Meir J. Stampfer, epidemiologist and nutrition expert at Harvard University. Trigger this skill when evaluating lifestyle factors, comparing…
Applies the reasoning, principles, and mental models of Oprah Winfrey (media mogul, founder of Harpo Productions and OWN network). Use this skill whenever the user is facing career trade-offs, seeking life purpose, struggling with failure or adversity, navigating difficult human connections, or making high-stakes…
Applies the reasoning of Pieter Abbeel, robotics and reinforcement learning expert, UC Berkeley professor, and co-founder of Covariant. Use this skill whenever you are designing AI systems, tackling Sim2Real transfer, deploying machine learning in the physical world, or evaluating reinforcement learning architectures.…
Applies the philosophical frameworks of Plato (ancient Greek philosopher, Theory of Forms, founder of the Academy) to structural, ethical, and epistemological problems. Use this skill whenever the user is grappling with organizational design, leadership ethics, defining abstract concepts, aligning incentives, or…
Applies the foundationalist reasoning and methodological doubt of René Descartes (17th-century French rationalist philosopher). Use this skill whenever the user is questioning fundamental assumptions, seeking absolute certainty in a decision, dismantling flawed systems, or trying to rebuild a project from first…
Reach for this skill whenever you are discussing reinforcement learning, agentic AI systems, AI alignment, continual learning, or the philosophical limits of large language models. This skill channels the thinking of Richard S. Sutton (reinforcement learning pioneer, University of Alberta, Keen Technologies, 2024…
Use this skill when reasoning about deep tech commercialization, biomedical engineering, drug delivery, material design, or overcoming institutional skepticism. Robert Langer, MIT professor and pioneer of drug delivery systems, approaches problems through first-principles engineering, interdisciplinary convergence…
This skill applies the analytical frameworks of Ronald C. Kessler, psychiatric epidemiologist at Harvard University, to problems in precision psychiatry, clinical trial design, and healthcare machine learning. Use this skill whenever you are designing clinical trials, evaluating mental health interventions, analyzing…
Apply this skill whenever the user is navigating early-stage startups, bootstrapping, product innovation, branding, or overcoming the fear of failure. Sara Blakely, founder of Spanx and self-made billionaire, approaches business by leveraging 'the outsider advantage,' relying on intuition, and obsessing over consumer…
AGENTS.md instructions for K-Dense-AI/rowan-autosearch, covering rowan autosearch — agent loop, the loop, inspect before you commit, proposing good candidates and writing rationales.
How to use the Adaptyv Bio Foundry API and Python SDK for protein experiment design, submission, and results retrieval. Use this skill whenever the user mentions Adaptyv, Foundry API, protein binding assays, protein screening experiments, BLI/SPR assays, thermostability assays, or wants to submit protein sequences for…
Turn a set of structures into absorption, distribution, metabolism, excretion, and toxicity estimates with ADMET-AI, and read them as a developability verdict rather than a table of numbers. Use this skill to run batch prediction over a library, interpret each endpoint against its DrugBank-approved percentile, and…
Number antibody variable domains, annotate CDRs, and assess developability from sequence. Use this skill to apply IMGT, Kabat, Chothia, Martin, or AHo numbering with ANARCI, delimit CDRs and framework regions, scan for chemical liabilities (N-glycosylation sequons, deamidation NG, isomerisation DG, oxidation, unpaired…
Structure-based docking with AutoDock Vina, Vinardo, and AutoDock4 through the Meeko toolchain. Use this skill to define a docking box, prepare receptors and ligands as PDBQT, run single or batch docking, rescore, and interpret affinities, poses, and ligand efficiency. Covers box definition from a reference ligand or…
Decide whether a protein has a pocket worth targeting, and where it is, before committing to a docking or design campaign. Use this skill to run fpocket cavity detection, rank cavities by druggability and volume, compare apo and holo conformations to spot induced fit, identify allosteric and cryptic cavities that only…
Cofold protein-ligand, protein-protein, and nucleic-acid complexes with Boltz-2, and predict binding affinity with its trained affinity head. Use this skill to build Boltz input YAML, run structure prediction with MSAs, pocket constraints, templates, and modified residues, screen compound libraries by cofolding, and…
Query the ChEMBL database web services for measured bioactivity data, compound records and calculated properties, targets, assays, mechanisms of action, drug indications and warnings. Use this skill to build curated SAR or QSAR datasets for a target, look compounds up by SMILES, InChIKey, name, or ChEMBL id, run…