synthetic-sciences

synthetic-sciences/openscience

Skill Claude CodeCodex

Use when working with Outpost Bio's open microbiome foundation models - the Waypoint checkpoints (Waypoint-6m, Waypoint-45m, Waypoint-170m), the Atlas pretraining corpus, the Compass eight-task benchmark, or the waypoint CLI from the waypoint-bio package. Covers embedding microbiome samples, fine-tuning on taxonomic…

synthetic-sciences/openscience

Skill Claude Code

Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP / / , ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays…

synthetic-sciences/openscience

Skill Claude CodeCodex

Run and analyze molecular dynamics simulations with OpenMM and MDAnalysis. Set up protein/small molecule systems, define force fields, run energy minimization and production MD, analyze trajectories (RMSD, RMSF, contact maps, free energy surfaces). For structural biology, drug binding, and biophysics.

synthetic-sciences/openscience

Skill Claude Code

Pharmacokinetic and pharmacodynamic modelling and simulation - non-compartmental analysis, compartmental and population PK, PK/PD and exposure-response, TMDD, PBPK orientation, bioequivalence, allometric scaling and first-in-human dose, drug interaction prediction, and Bayesian therapeutic drug monitoring. Use when…

synthetic-sciences/openscience

Skill Claude CodeCodex

GPU-accelerates scientific Python on NVIDIA hardware and verifies that the result is correct and faster. Use for CUDA/GPU optimization; CPU-bound NumPy, SciPy, pandas, scikit-learn, NetworkX, scikit-image, vector-search, image-processing, graph, simulation, or file-I/O workloads; CuPy, cuDF, cuML, cuGraph, cuVS…

synthetic-sciences/openscience

Skill Claude Code

Zero-shot time series forecasting with Google's TimesFM foundation model. Use for any univariate time series (sales, sensors, energy, vitals, weather) without training a custom model. Supports CSV/DataFrame/array inputs with point forecasts and prediction intervals. Includes a preflight system checker script to verify…

synthetic-sciences/openscience

Skill Claude Code

Runs a hill-climbing study over many training or analysis runs with the study and experiments tools, one metric and direction, a baseline, ideas ranked by expected value, exactly one run per idea, kill criteria and a budget, verdicts with analysis and lessons, and a conclusion. Use for autoresearch, hyperparameter or…

synthetic-sciences/openscience

Skill Claude Code

Generates and selects research directions, mapping what is known and what is open, producing many candidate ideas by named moves (gap, transfer, inversion, constraint change, scale, failure analysis), then ranking them by tractability and value and committing to a shortlist. Use for open-ended ideation, "what should I…

synthetic-sciences/openscience

Skill Claude Code

Resolves, verifies and formats references, every citation confirmed against Crossref, OpenAlex, arXiv or PubMed before it enters the bibliography, BibTeX built from resolved metadata, and existing .bib files audited for fabricated or mismatched entries. Use when adding citations to a draft, building or repairing a…

synthetic-sciences/openscience

Skill Claude Code

Chooses and runs compute for research work, local shell or kernel versus a detached computejob on this machine, a saved SSH or Slurm host, or Modal GPUs, with the target discovered from what is actually configured, the run sized and priced before dispatch, outputs declared, metrics tracked, and long work handed to the…

synthetic-sciences/openscience

Skill Claude Code

Delegates independent work to worker agents through the Task tool, choosing between the explore scout and the ml, biology, physics, chemistry and data specialists, writing a self-contained brief for a worker that cannot see the conversation, setting boundaries on files and compute, using two independent annotators…

synthetic-sciences/openscience

Skill Claude Code

Makes publication-quality plots from data with matplotlib, learning curves, scaling laws, benchmark and ablation comparisons, Pareto trade-offs, heatmaps and confusion matrices, sized for the page, vector, with uncertainty shown. Use whenever results are plotted, charted or visualized for a paper, report or answer, or…

synthetic-sciences/openscience

Skill Claude Code

Turns a research direction into testable hypotheses with predictions, competing explanations and the experiments that discriminate between them, including the design (controls, randomization, blocking), sample size or seed count, the pre-specified analysis, and the result that would falsify each hypothesis. Use when a…

synthetic-sciences/openscience

Skill Claude Code

Finds, ranks and reads the literature on a question, the retrieval loop the lead runs itself over OpenAlex, arXiv, Crossref, PubMed and bioRxiv with a fixed budget, deduplication, ranking by topical fit, reading of the load-bearing papers and claim-level links, for related-work sections, prior-art checks, surveys and…

synthetic-sciences/openscience

Skill Claude Code

Writes and revises machine-learning papers for NeurIPS, ICML, ICLR, ACL, COLM and AAAI, from a research repository or a set of tracked runs to a compiling LaTeX draft in the venue's template, with the contribution stated as claims backed by experiments, ablations and honest baselines. Use for ML or AI conference…

synthetic-sciences/openscience

Skill Claude Code

Writes and revises scientific manuscripts, journal articles, preprints, theses, reports, in full paragraphs with the argument built from the project's actual results and sources, as a real .tex or .md file in the working folder. Use for drafting or revising a paper, a section, an abstract, a response to reviewers, or…

synthetic-sciences/openscience

Skill Claude Code

Reviews a manuscript, proposal, analysis or result the way a careful referee does, reading the whole artifact, checking the methods against the claims, the statistics against the design, the figures against the numbers, and reporting BLOCKING issues separately from observations, with a calibrated recommendation. Use…

synthetic-sciences/openscience

Skill Claude Code

Reproduces a paper's result, a claim, an artifact or a previous run with the target and success criterion frozen first, the canonical code path run before any substitute, exact inputs, environment, seeds and commands captured, and a verdict from a fixed set, reproduced, reproduced within tolerance, partially…

synthetic-sciences/openscience

Skill Claude Code

Answers a focused factual or technical question from current sources with links, a definition, a number, a method's origin, a library's behavior, what a specific paper found, using literature, researchsearch, webfetch and the scholarly APIs, and knowing when the question is really a literature review. Use for quick…

synthetic-sciences/openscience

Skill Claude Code

Creates or refines publication-quality technical diagrams with the native generateimage tool (Nano Banana Pro through Ace or a Gemini key, GPT Image 2 through an OpenAI key), method and architecture overviews, pipelines, CONSORT and PRISMA flows, experimental workflows, biological pathways, circuits and conceptual…

synthetic-sciences/openscience

Skill Claude Code

Audits claims against their sources, each statement in a draft, report, answer or summary traced to the passage, table, dataset or run that supports it, and marked supported, partially supported, unsupported or contradicted, with a provenance table as the deliverable. Use for a sources audit, fact-check, "is this…

synthetic-sciences/openscience

Skill Claude Code

Retrieve, version, and publish scientific datasets with DataLad and git-annex, and capture computational provenance with datalad run, rerun, and containers-run. Use when cloning or fetching data from OpenNeuro, DANDI, datasets.datalad.org, or any DataLad dataset; when a file in a dataset reads as a broken symlink or a…

synthetic-sciences/openscience

Skill Claude CodeCodex

Comprehensive geospatial science skill covering remote sensing, GIS, spatial analysis, machine learning for earth observation, and 30+ scientific domains. Supports satellite imagery processing (Sentinel, Landsat, MODIS, SAR, hyperspectral), vector and raster data operations, spatial statistics, point cloud processing…

synthetic-sciences/openscience

Skill Claude Code

Query documented public database APIs with explicit endpoints, filters, pagination, and provenance. Use when a scientific, regulatory, financial, or other database-backed fact must be retrieved reproducibly from a named source rather than inferred from general knowledge.