Time-to-event analysis for cancer clinical data. Covers Kaplan-Meier, Cox proportional hazards, competing risks, restricted mean survival time, and optimal cutpoint selection using the survival, ggsurvfit, tidycmprsk, and survRM2 packages.
Annotation and clinical interpretation of DNA variants in cancer. Covers VCF normalization and filtering, functional annotation with VEP, germline classification under ACMG/AMP, somatic classification under the AMP/ASCO/CAP tiers and the ClinGen/CGC/VICC oncogenicity standard, tumor mutational burden, microsatellite…
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originalMIT
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