ai4nucleome/BioMaster

113Stars on the repository
199Mods indexed here, across every type
2mo agoLast push, which is what freshness is scored on
noneNo LICENSE: all rights reserved, so bodies are not copied

pathway-query-kegg

151

ai4nucleome/BioMaster

Skill OpenCode

Query the KEGG REST API for biological pathways, pathway gene lists, and gene info. Use when users ask about metabolic/signaling pathways, pathway genes, KEGG IDs, or gene-to-pathway mapping.

not rated 113 +1 2mo ago A 48 tokens

plan-metagenomics

153

ai4nucleome/BioMaster

Skill OpenCode

Generate PLAN.yaml for detailed metagenomic analysis using R phyloseq-based functions.

not rated 113 +1 2mo ago A 22 tokens

ai4nucleome/BioMaster

Skill OpenCode

Ligand-aware protein sequence design with LigandMPNN for small molecules, metals, cofactors, and DNA/RNA binding sites.

not rated 113 +1 2mo ago A 35 tokens

proteomics-alphafold

156

ai4nucleome/BioMaster

Skill OpenCode

Validate protein designs using AlphaFold2 structure prediction: select backend, run prediction, extract confidence metrics (pLDDT, pTM, ipTM, PAE), assess quality against thresholds, and troubleshoot runtime errors.

not rated 113 +1 2mo ago A 51 tokens

ai4nucleome/BioMaster

Skill OpenCode

Install and run RefHiC for reference-panel-guided Hi-C loop calling and TAD boundary annotation, including reference panel configuration, prediction, FDR-based selection, and output interpretation.

not rated 113 +1 2mo ago A 47 tokens

registry

158

ai4nucleome/BioMaster

Skill OpenCode

Route user requests to domain, discipline, and candidate tumor scRNA-seq pipelines via SQLite pipeline routes.

not rated 113 +1 2mo ago A 23 tokens

ai4nucleome/BioMaster

Skill OpenCode

Annotated matrices for single-cell genomics. Stores X with obs/var metadata, layers, embeddings (obsm/varm), graphs (obsp/varp), uns. Use for .h5ad/.zarr I/O, concatenation, scverse integration. For analysis use scanpy; for probabilistic models use scvi-tools.

not rated 113 +1 2mo ago A 79 tokens

ai4nucleome/BioMaster

Skill OpenCode

GRN inference from expression via GRNBoost2 (gradient boosting) or GENIE3 (Random Forest). Load matrix, filter by TFs, infer TF-target-importance links, save network. Dask-parallelized to single-cell scale. Core SCENIC component.

not rated 113 +1 2mo ago A 68 tokens

ai4nucleome/BioMaster

Skill OpenCode

Infer and visualize intercellular communication from scRNA-seq with CellChat (R). Build CellChat from Seurat/counts → subset CellChatDB ligand-receptor pairs → over-expressed genes per group → communication probabilities → pathway signaling → network centrality (senders/receivers/influencers) → chord/heatmap/bubble…

not rated 113 +1 2mo ago A 96 tokens

ai4nucleome/BioMaster

Skill OpenCode

Automated scRNA-seq cell type annotation via pre-trained logistic regression. 45+ models: immune, gut, lung, brain, fetal, cancer microenvironments. Input normalized AnnData; outputs per-cell labels, majority-vote cluster labels, confidence scores. Use for fast, reference-backed annotation without manual marker…

not rated 113 +1 2mo ago A 76 tokens

ai4nucleome/BioMaster

Skill OpenCode

ENCODE Portal REST API for regulatory genomics: TF ChIP-seq, ATAC-seq/DNase-seq peaks, histone marks, and RNA-seq across 1000+ cell types. Search experiments by assay/biosample/target; download BED/bigWig; retrieve SCREEN cCREs by region or gene. Use to annotate variants with regulatory tracks, find open chromatin in…

not rated 113 +1 2mo ago A 128 tokens

sciagent-geo-database

165

ai4nucleome/BioMaster

Skill OpenCode

NCBI GEO access via GEOparse and E-utilities. Search by keyword/organism/platform, download GSE series matrices, parse GPL annotations, extract GSM metadata, load expression matrices into pandas. For single-cell use cellxgene-census; for multi-DB access use gget-genomic-databases.

not rated 113 +1 2mo ago A 72 tokens

ai4nucleome/BioMaster

Skill OpenCode

Unified CLI/Python interface to 20+ genomic databases. Gene lookups (Ensembl search/info/seq), BLAST/BLAT, AlphaFold, Enrichr enrichment, OpenTargets disease/drug, CELLxGENE single-cell, cBioPortal/COSMIC cancer, ARCHS4 expression. Spans genomics, proteomics, disease. For batch/advanced BLAST use biopython; for…

not rated 113 +1 2mo ago A 105 tokens

ai4nucleome/BioMaster

Skill OpenCode

Harmony batch correction for scRNA-seq and other omics. Removes batch effects from PCA embeddings while preserving biology. Run after PCA, before UMAP. Scales to millions of cells. Python (harmonypy, scanpy) and R (Seurat).

not rated 113 +1 2mo ago A 63 tokens

ai4nucleome/BioMaster

Skill OpenCode

Open-source FAIR biology data framework. Version artifacts (AnnData, DataFrame, Zarr), track lineage, validate via ontologies (Bionty), query datasets. Integrates with Nextflow, Snakemake, W&B, scVI. For scRNA-seq use scanpy; for ontology lookups use bionty.

not rated 113 +1 2mo ago A 78 tokens

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