The largest open-source medical AI skills library for OpenClaw🦞.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instruments, or running sensitivity analyses for…
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio. Applies cfDNA-specific quality thresholds and fragment length filtering. Use when processing plasma cfDNA sequencing data before downstream analysis.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Differential binding analysis using DiffBind. Compare ChIP-seq peaks between conditions with statistical rigor. Requires replicate samples. Outputs differentially bound regions with fold changes and p-values. Use when comparing ChIP-seq binding between conditions.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
De novo motif discovery and known motif enrichment analysis using HOMER and MEME-ChIP. Identify transcription factor binding motifs in ChIP-seq, ATAC-seq, or other genomic peak data. Use when finding enriched DNA motifs in peak sequences.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Annotate ChIP-seq peaks to genomic features and genes using ChIPseeker. Assign peaks to promoters, exons, introns, and intergenic regions. Find nearest genes and calculate distance to TSS. Generate annotation plots and statistics. Use when annotating ChIP-seq peaks to genomic features.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
ChIP-seq peak calling using MACS3 (or MACS2). Call narrow peaks for transcription factors or broad peaks for histone modifications. Supports input control, fragment size modeling, and various output formats including narrowPeak and broadPeak BED files. Use when calling peaks from ChIP-seq alignments.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
ChIP-seq quality control metrics including FRiP (Fraction of Reads in Peaks), cross-correlation analysis (NSC/RSC), library complexity, and IDR (Irreproducibility Discovery Rate) for replicate concordance. Use to assess experiment quality before downstream analysis. Use when assessing ChIP-seq data quality metrics.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Identifies super-enhancers from H3K27ac ChIP-seq data using ROSE and related tools. Use when studying cell identity genes, cancer-associated regulatory elements, or master transcription factor binding regions that cluster into large enhancer domains.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Visualize ChIP-seq data using deepTools, Gviz, and ChIPseeker. Create heatmaps, profile plots, and genome browser tracks. Visualize signal around peaks, TSS, or custom regions. Use when visualizing ChIP-seq signal and peaks.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Use when determining clinical significance of variants for diagnostic or research purposes.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Query dbSNP for rsID lookups, variant annotations, and cross-references to other databases. Use when mapping between rsIDs and genomic coordinates or retrieving basic variant information.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Query gnomAD for population allele frequencies to assess variant rarity. Use when filtering variants by population frequency for rare disease analysis or determining if a variant is common in the general population.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Call HLA alleles from NGS data using OptiType, HLA-HD, or arcasHLA for immunogenomics applications. Use when determining HLA genotype for transplant matching, neoantigen prediction, or pharmacogenomic screening.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Query myvariant.info API for aggregated variant annotations from multiple databases (ClinVar, gnomAD, dbSNP, COSMIC, etc.) in a single request. Use when annotating variants with clinical and population data from multiple sources simultaneously.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Query PharmGKB and CPIC for drug-gene interactions, pharmacogenomic annotations, and dosing guidelines. Use when predicting drug response from genetic variants or implementing clinical pharmacogenomics.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Calculate polygenic risk scores using PRSice-2, LDpred2, or PRS-CS from GWAS summary statistics. Use when predicting disease risk from genome-wide genetic variants.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Extract and analyze mutational signatures from somatic variants using SigProfiler or MutationalPatterns to characterize mutagenic processes. Use when identifying DNA damage mechanisms or etiology in cancer genomes.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Calculate tumor mutational burden from panel or WES data with proper normalization and clinical thresholds. Use when assessing immunotherapy eligibility or characterizing tumor immunogenicity.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Filter and prioritize variants by pathogenicity, population frequency, and clinical evidence for rare disease analysis. Use when identifying candidate disease-causing variants from exome or genome sequencing.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Skill "bio-clip-seq-binding-site-annotation" from FreedomIntelligence/OpenClaw-Medical-Skills, covering copyright notice, copyright (c) 2026 md babu mia, phd, all rights reserved, this code is proprietary and confidential and provenance: authenticated by md babu mia.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Skill "bio-clip-seq-clip-alignment" from FreedomIntelligence/OpenClaw-Medical-Skills, covering copyright notice, copyright (c) 2026 md babu mia, phd, all rights reserved, this code is proprietary and confidential and provenance: authenticated by md babu mia.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Skill "bio-clip-seq-clip-motif-analysis" from FreedomIntelligence/OpenClaw-Medical-Skills, covering copyright notice, copyright (c) 2026 md babu mia, phd, all rights reserved, this code is proprietary and confidential and provenance: authenticated by md babu mia.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Skill "bio-clip-seq-clip-peak-calling" from FreedomIntelligence/OpenClaw-Medical-Skills, covering copyright notice, copyright (c) 2026 md babu mia, phd, all rights reserved, this code is proprietary and confidential and provenance: authenticated by md babu mia.
FreedomIntelligence/OpenClaw-Medical-Skills
Skill Claude CodeCodex
Skill "bio-clip-seq-clip-preprocessing" from FreedomIntelligence/OpenClaw-Medical-Skills, covering copyright notice, copyright (c) 2026 md babu mia, phd, all rights reserved, this code is proprietary and confidential and provenance: authenticated by md babu mia.
At most 3 mods per repository are shown here, and a mod shipped inside a plugin is left to that plugin's page — the rest are on their repository pages: