interpro-database

A searchable protein database that combines results from 14 sources, including Pfam and CDD. It helps identify protein families, domains, and sites, which are functional or structural parts of proteins.

In plain words
What is it for?
Use it to examine a protein, find other proteins with a shared family or domain, compare where those features occur across species, and annotate genomes with protein families and Gene Ontology terms.
Why use it?
It brings related protein information into one place, reducing the need to search separate databases and compare overlapping results.

Skill for Claude CodeCodex

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add skills/google-deepmind/science-skills/interpro_database
Any agent
npx skills add google-deepmind/science-skills --skill interpro_database
Clone the repo
git clone --depth 1 https://github.com/google-deepmind/science-skills

Made for: Claude Code, Codex.

Per session 84 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 4,198 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. Scan, not verified.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5 $0.00084 $0.04198
Opus 5 $0.00042 $0.02099
Sonnet 5 $0.00017 $0.00840
Haiku 4.5 $0.00008 $0.00420

Measured 3d ago against content hash ab24b2241057, method: parsed. Prices are Anthropic first-party input rates as of 2026-08-30, from the pricing page.

Security

Grade A, and why

interpro-database scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 3d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (scripts/interpro_client.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/interpro_database/SKILL.md · 428 lines

How it starts

The opening of the file, as written. The whole thing — 428 lines — stays where its author put it; the contents beside it link to each section on GitHub.

InterPro Database Access

Prerequisites

  1. uv: Read the uv skill and follow its Setup instructions to ensure uv is installed and on PATH.
  2. User Notification: If .licenses/interpro_database_LICENSE.txt does not already exist in the workspace root directory then (1) prominently notify the user to check the terms at https://www.ebi.ac.uk/interpro/ and https://www.ebi.ac.uk/about/terms-of-use/, then (2) create the file recording the notification text and timestamp.

Overview

InterPro combines signatures from multiple, diverse databases into a single searchable resource, reducing redundancy and helping users interpret their sequence analysis results. By uniting these member databases (e.g., Pfam, CDD, SMART), InterPro capitalises on their individual strengths to produce a powerful diagnostic tool and integrated resource.

Use interpro-database to:

  • Identify what domains, families, and sites are found in a particular protein.
  • Identify all proteins that belong to a protein family or contain a particular domain, even when the names and activities of the proteins are highly variable.
  • Examine the species in which a particular protein family or domain is found.
  • Annotate genomes with protein family information and Gene Ontology (GO) terms.

This skill provides a robust utility, interpro_client.py, to interact with the InterPro API seamlessly. It natively handles rate limiting (HTTP 429), background query sleep tracking (HTTP 408), terminal errors (HTTP 404/410), and lazy pagination.

Core Rules

  • Use the Wrapper: ALWAYS execute the scripts/interpro_client.py helper script to query the database rather than accessing the database directly. The scripts automatically enforce fair use and implement retry logic.
  • For exploratory queries: ALWAYS use the CLI with a strict --limit. This allows you to rapidly understand the data schema without polluting your context window or fetching millions of results.
  • Output to file: Use the CLI with --output to output to a file rather than attempting to print it all to the console. Process the output using jq or code.
  • For more complex pipelines import the module natively into your Python scripts to consume the generator directly, preventing the need to deserialize CLI strings in large workflows.
  • Notification: If this skill is used, ensure this is mentioned in the output.

Read the full file on GitHub · 428 lines

Files

What ships with it

4 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 3d ago First seen · 428 lines · 84 tokens per session scan A ab24b2241057

Subscribe to this mod's changes

interpro-database is a skill published in the GitHub repository google-deepmind/science-skills (2,814 stars, last pushed 1mo ago), licensed Apache-2.0. It adds 84 tokens to every session and 4,198 once invoked, about $0.0004 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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