bio-local-blast

bio-local-blast is a skill for Claude Code, Codex from thesecondfox/skill. It costs 45 tokens per session (3,093 once invoked), scanned B, original, MIT.

A guide to running BLAST searches on your own computer with NCBI BLAST+, against a database you build yourself. BLAST compares DNA or protein sequences to find similar sequences and reports measures such as identity and e-value.

In plain words
What is it for?
Use it to build local nucleotide or protein databases, search them with DNA or protein queries, and produce tabular similarity results.
Why use it?
Local searches avoid relying on NCBI servers when they are slow or unavailable and support repeated or large-scale searches. They also let you search custom sequence collections.

Skill for Claude CodeCodex

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add skills/thesecondfox/skill/bio-database-access-local-blast
Any agent
npx skills add thesecondfox/skill --skill bio-database-access-local-blast
Clone the repo
git clone --depth 1 https://github.com/thesecondfox/skill

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for bio-local-blast

README.md
[![agentmods](https://agentmods.dev/badge/skills/thesecondfox/skill/bio-database-access-local-blast.svg)](https://agentmods.dev/skills/thesecondfox/skill/bio-database-access-local-blast)
Your own site
<a href="https://agentmods.dev/skills/thesecondfox/skill/bio-database-access-local-blast"><img src="https://agentmods.dev/badge/skills/thesecondfox/skill/bio-database-access-local-blast.svg" alt="Measured on agentmods" height="20"></a>
Per session 45 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,093 The whole file, excluding the scripts and references it only reads on demand.
Security scan B 2 findings. Scan, not verified.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5 $0.00045 $0.03093
Opus 5 $0.00023 $0.01546
Sonnet 5 $0.00009 $0.00619
Haiku 4.5 $0.00005 $0.00309

Measured 4d ago against content hash 3725d0a4eb78, method: parsed. Prices are Anthropic first-party input rates as of 2026-08-30, from the pricing page.

Security

Grade B, and why

bio-local-blast scanned grade B with 2 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 4d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Asks for rootmediumPrivilege escalation

A mod that escalates privileges can change anything on the machine, not only the project.

sudo apt install ncbi-blast+

Runs shell commandslowCapability

Expected in a hook, worth knowing in a rule or an instructions file.

subprocess.run(cmd, check=True)
Common_Skills/bio-database-access-local-blast/SKILL.md · 354 lines

How it starts

The opening of the file, as written. The whole thing — 354 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Version Compatibility

Reference examples tested with: NCBI BLAST+ 2.15+

Before using code patterns, verify installed versions match. If versions differ:

  • Python: pip show <package> then help(module.function) to check signatures
  • CLI: <tool> --version then <tool> --help to confirm flags

If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying.

Local BLAST

"Run a BLAST search against my custom database" → Build a local BLAST database and search it with query sequences, returning tabular results with identity and e-value.

  • CLI: makeblastdb, blastn/blastp (NCBI BLAST+)
  • Python: subprocess wrapper for BLAST+

Run BLAST searches locally using NCBI BLAST+ command-line tools.

Installation (NCBI BLAST+)

# macOS
brew install blast

# Ubuntu/Debian
sudo apt install ncbi-blast+

# conda
conda install -c bioconda blast

# Verify installation
blastn -version

BLAST+ Programs

Command Query Database Description
blastn DNA DNA Nucleotide-nucleotide
blastp Protein Protein Protein-protein
blastx DNA Protein Translated query vs protein
tblastn Protein DNA Protein vs translated DB
tblastx DNA DNA Translated vs translated
makeblastdb - - Create BLAST database

Creating BLAST Databases

makeblastdb - Create Database (NCBI BLAST+)

# Create nucleotide database
makeblastdb -in sequences.fasta -dbtype nucl -out my_db

# Create protein database
makeblastdb -in proteins.fasta -dbtype prot -out my_proteins

# With title and parse sequence IDs
makeblastdb -in sequences.fasta -dbtype nucl -out my_db \
    -title "My Reference Database" -parse_seqids

Key Options:

Option Description Values
-in Input FASTA file Path
-dbtype Database type nucl, prot
-out Output database name Path prefix
-title Database title String
-parse_seqids Enable ID-based retrieval Flag
-taxid Assign taxonomy ID Integer
-taxid_map Taxonomy ID mapping file Path

Read the full file on GitHub · 354 lines

Files

What ships with it

1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 4d ago First seen · 354 lines · 45 tokens per session scan B 3725d0a4eb78

Subscribe to this mod's changes

bio-local-blast is a skill published in the GitHub repository thesecondfox/skill (3 stars, last pushed 5mo ago), licensed MIT. It adds 45 tokens to every session and 3,093 once invoked, about $0.0002 per session on Opus 5. A static security scan graded it B with 2 findings (asks for root, runs shell commands). No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-31.

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