Query the ADReCS (Adverse Drug Reaction Classification System) v3.3 database. Use whenever the user asks about adverse drug reactions, drug safety profiles, ADR classification, ADR severity/frequency, or wants to look up any entity (drug name, BADD Drug ID, DrugBank ID, ATC code, CAS RN, PubChem CID, KEGG ID, ADR…
Query the FDA Adverse Event Reporting System (FAERS) via openFDA API. Use whenever the user asks about adverse drug reactions, side effects, drug safety signals, or wants to look up reported adverse events for one or more drug names.
Query the nSIDES drug side effect databases (OnSIDES, OffSIDES, KidSIDES). Use whenever the user asks about drug adverse reactions, side effects, off-label safety signals, or pediatric drug safety for a given drug name.
Query the DDInter drug-drug interaction database. Use whenever the user asks about drug-drug interactions, DDI severity levels, or wants to look up interactions for a drug name or DDInter ID.
Query the MecDDI mechanism-based drug-drug interaction database. Use whenever the user asks about drug-drug interactions, DDI mechanisms (PK/PD), enzyme or transporter-mediated interactions, or wants to look up interacting drug pairs by drug name or MecDDI drug ID. Trigger on keywords like DDI, drug interaction…
Query the DrugComb drug combination database for cancer cell-line synergy and sensitivity data. Use whenever the user asks about drug combinations, synergy scores (ZIP/Bliss/Loewe/HSA), combination sensitivity (CSS), or wants to look up how two drugs interact in a specific cancer cell line.
The pair and recommendation tables use drugid (e.g. RxNorm:32968), not drug name. This script resolves drug names automatically via the /v1/drug table before querying.
Query a locally downloaded DrugBank database. Use whenever the user asks about drug information, drug targets, drug-drug interactions, drug categories, or wants to look up any entity (DrugBank ID, drug name, CAS number, synonym) in DrugBank.
Query the DrugCentral drug pharmacology database. Use whenever the user asks about approved drug structures, drug targets, pharmacological actions, or wants to look up any entity (drug name, DrugCentral ID, CAS number, InChIKey) in DrugCentral.
Query or inspect the FDA Orange Book - FDA-Approved Drug Products Listing resource for drug-centric tasks with emphasis on drug knowledgebase Use whenever Codex needs the calling pattern, downloadable entrypoint, or example query flow from this skill example script.
Query the IUPHAR/BPS Guide to Pharmacology REST API for drug targets, ligands (drugs/compounds), and their interactions. Use whenever the user asks about pharmacological targets, receptor–ligand relationships, drug mechanisms of action, or wants to look up any drug or target name in IUPHAR. Supports single entity or…
Query the PharmKG knowledge graph (180k entities, 39 relation types, >1M triples). Use whenever the user asks about biomedical relationships among genes, drugs/chemicals, and diseases — e.g. drug–gene interactions, drug–disease associations, gene–disease links, or drug–drug relationships derived from literature and…
UniD3 is a multi-knowledge-graph built from 150,000+ PubMed articles, stored as 6 GraphML files. It supports drug-disease matching, effectiveness assessment, and drug-target analysis.
Query the WHO Model List of Essential Medicines (23rd list, 2023). Use whenever the user asks about essential medicines, WHO-recommended drugs, dosage forms, therapeutic sections, or AWaRe antibiotic classification.
Query DailyMed for FDA drug label / package insert information. Use whenever the user asks about drug labeling, SPL documents, prescribing information, NDC codes, or needs to look up current FDA-approved drug details by name or NDC. Supports single entity or batch queries.
Query MedlinePlus for consumer-oriented drug and health-topic information. Accepts drug names, RxCUI codes, NDC codes, or ICD-10-CM diagnosis codes. Uses two free, keyless NLM APIs: the Web Service (keyword search) and MedlinePlus Connect (code-based lookup).
Query FDA drug labeling data via openFDA. Use whenever the user asks about drug prescribing information — indications, warnings, dosage, adverse reactions, contraindications, or administration routes. Supports single or batch lookup by brand/generic name or by indication/condition.
Query the DrugMechDB drug mechanism-of-action database. Use whenever the user asks about drug mechanisms, drug-to-disease paths, biological targets of a drug, or wants to look up any biomedical entity (drug name, protein, disease, DrugBank ID, MESH ID, UniProt ID, GO term, etc.) in DrugMechDB.
GDSC contains pharmacological profiles for 500 drugs tested in 1,000 cancer cell lines. Queryable entities include drug names, gene targets, pathways, and cell-line identifiers.
ADE Corpus V2 — Adverse Drug Event relation extraction dataset from annotated PubMed case reports.
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