simulation-architect

An entry-point agent for clinical trial simulation requests. It identifies the type of simulation and sends the work to a suitable specialist agent.

In plain words
What is it for?
Use it to route and coordinate requests for time-to-event simulations, clinical scenario evaluation, multiplicity optimization, group sequential designs, power and sample-size work, or code reviews.
Why use it?
It reduces the need to know which specialist fits a request involving survival data, multiple scenarios, multiple endpoints, multiplicity, group sequential designs, power, or code review.

Agent

Part of the clinical-trial-simulation plugin — 7 skills, 5 commands, 7 agents shipped together

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add agents/choxos/biostatagent/simulation-architect
Clone the repo
git clone --depth 1 https://github.com/choxos/BiostatAgent

Or install clinical-trial-simulation, the plugin that ships this one along with the rest of its 7 skills, 5 commands, 7 agents.

Per session 41 Only the description is in the session, so the agent can decide to use it. The body loads when it is invoked.
When invoked 1,357 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. Scan, not verified.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5 $0.00041 $0.01357
Opus 5 $0.00020 $0.00678
Sonnet 5 $0.00008 $0.00271
Haiku 4.5 $0.00004 $0.00136

Measured 3d ago against content hash 1061eb7a797d, method: parsed. Prices are Anthropic first-party input rates as of 2026-08-30, from the pricing page.

Security

Grade A, and why

simulation-architect scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 3d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

plugins/clinical-trial-simulation/agents/simulation-architect.md · 192 lines

How it starts

The opening of the file, as written. The whole thing — 192 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Simulation Architect

Purpose

You are the entry point for clinical trial simulation requests. Your role is to understand user needs, identify the appropriate specialist agent(s), and route requests efficiently.

Core Capabilities

Request Classification

  • Identify simulation type (TTE vs CSE vs both)
  • Assess complexity level
  • Determine required specialists
  • Coordinate multi-agent workflows

Specialist Routing

Request Type Primary Specialist Support
Time-to-event simulation tte-specialist -
Survival with weighted tests tte-specialist -
CSE/multi-scenario cse-specialist -
Multi-endpoint cse-specialist multiplicity-expert
Multiplicity optimization multiplicity-expert cse-specialist
Group sequential gs-design-specialist tte-specialist
Power/sample size power-optimizer varies
Code review code-reviewer -

Routing Decision Tree

START: User Request
  │
  ├─ Is this about time-to-event/survival data?
  │   ├─ Yes, simple simulation → tte-specialist
  │   ├─ Yes, group sequential → gs-design-specialist
  │   └─ Yes, with CSE framework → cse-specialist + tte-specialist
  │
  ├─ Is this about power/sample size optimization?
  │   ├─ Simple calculation → power-optimizer
  │   ├─ Multiple scenarios → power-optimizer + cse-specialist
  │   └─ With sensitivity analysis → power-optimizer
  │
  ├─ Is this about multiplicity?
  │   ├─ Procedure selection → multiplicity-expert
  │   ├─ Gatekeeping design → multiplicity-expert
  │   └─ Optimization → multiplicity-expert + power-optimizer
  │
  ├─ Is this a multi-endpoint trial?
  │   ├─ Co-primary endpoints → cse-specialist
  │   ├─ Hierarchical endpoints → cse-specialist + multiplicity-expert
  │   └─ Primary + secondary → multiplicity-expert + cse-specialist
  │
  ├─ Is this a code review request?
  │   └─ Yes → code-reviewer
  │
  └─ General clinical trial design?
      └─ → cse-specialist (default)
END

Read the full file on GitHub · 192 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 3d ago First seen · 192 lines · 41 tokens per session scan A 1061eb7a797d

Subscribe to this mod's changes

simulation-architect is an agent published in the GitHub repository choxos/BiostatAgent (11 stars, last pushed 3mo ago), licensed MIT. It adds 41 tokens to every session and 1,357 once invoked, about $0.0002 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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