chromatographer

chromatographer is an agent for Claude Code from pjt222/agent-almanac. It costs 23 tokens per session (2,246 once invoked), scanned A, original, MIT.

A specialist for developing and validating GC and HPLC laboratory separation methods. GC means gas chromatography and HPLC means high-performance liquid chromatography; ICH Q2 is an international guideline for proving that analytical methods are fit for purpose.

In plain words
What is it for?
Use it to develop or validate GC and HPLC methods, investigate separation problems, interpret chromatograms, and assess compliance with ICH Q2(R2).
Why use it?
It helps troubleshoot poor separations, choose method settings, interpret chromatograms, and document whether results are reliable for regulatory use.

Agent for Claude Code

Written for Claude Code: shipped in a Claude Code plugin. Also seen: model in frontmatter.

Part of the agent-almanac plugin — 122 skills, 76 agents shipped together

Good fit Use it to develop or validate GC and HPLC methods, investigate separation problems, interpret chromatograms, and assess compliance with ICH Q2(R2).

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Install with agentmods
npx agentmods add agents/pjt222/agent-almanac/chromatographer
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Clone the repo
git clone --depth 1 https://github.com/pjt222/agent-almanac

Made for: Claude Code.

Or install agent-almanac, the plugin that ships this one along with the rest of its 122 skills, 76 agents.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for chromatographer

README.md
[![agentmods](https://agentmods.dev/badge/agents/pjt222/agent-almanac/chromatographer.svg)](https://agentmods.dev/agents/pjt222/agent-almanac/chromatographer)
Your own site
<a href="https://agentmods.dev/agents/pjt222/agent-almanac/chromatographer"><img src="https://agentmods.dev/badge/agents/pjt222/agent-almanac/chromatographer.svg" alt="Measured on agentmods" height="20"></a>
Per session 23 Only the description is in the session, so the agent can decide to use it. The body loads when it is invoked.
When invoked 2,246 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00023 $0.02246
Opus 5 $0.00012 $0.01123
Sonnet 5 $0.00005 $0.00449
Haiku 4.5 $0.00002 $0.00225

Measured 8d ago against content hash fbc8195ff2b3, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-08, from the pricing page.

Security

Grade A, and why

chromatographer scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 8d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

agents/chromatographer.md · 166 lines

How it starts

The opening of the file, as written. The whole thing — 166 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Chromatographer Agent

A chromatographic method development and validation specialist covering gas chromatography (GC), high-performance liquid chromatography (HPLC), chromatogram interpretation, separation troubleshooting, and ICH Q2(R2) method validation. Develops separation methods, diagnoses problems, and validates analytical procedures for regulatory compliance.

Purpose

This agent assists with the full chromatographic workflow: selecting the right separation technique, developing optimized methods, interpreting chromatographic data, diagnosing separation failures, and validating methods to ICH Q2 standards. It bridges method development (getting a working separation) and method validation (proving the method is fit for purpose), ensuring analytical results are reliable and defensible.

Capabilities

  • GC Method Development: Column selection (polarity matching), temperature program optimization (initial temp, ramp rates, holds), carrier gas selection (He/H2/N2 tradeoffs), detector choice (FID, TCD, ECD, MS)
  • HPLC Method Development: Column chemistry selection (C18, HILIC, ion-exchange, SEC, chiral), mobile phase and gradient design, pH optimization for ionizable analytes, detector selection (UV/DAD, fluorescence, RI, MS)
  • Chromatogram Interpretation: Peak identification (retention time matching, spectral confirmation), integration (baseline selection, area calculation), system suitability evaluation (plates, resolution, tailing, RSD)
  • Separation Troubleshooting: Peak shape diagnosis (tailing, fronting, splitting, broadening), retention shift analysis, matrix effect evaluation, systematic one-variable-at-a-time resolution
  • Method Validation: ICH Q2(R2) parameters (specificity, linearity, accuracy, precision, LOD/LOQ, robustness), forced degradation studies, acceptance criteria per method category
  • Artifact Authoring & Implementation: Can now write its own outputs directly — method procedures, validation reports, troubleshooting findings, and SST tables — and apply method-file or documentation changes itself, rather than only proposing them for someone else to enter

Read the full file on GitHub · 166 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 8d ago First seen · 166 lines · 23 tokens per session scan A fbc8195ff2b3

Subscribe to this mod's changes

chromatographer is an agent published in the GitHub repository pjt222/agent-almanac (32 stars, last pushed today), licensed MIT. It adds 23 tokens to every session and 2,246 once invoked, about $0.0001 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.