multiplicity-optimization

A workflow for choosing and tuning statistical methods that adjust for multiple tests in clinical trials. It considers trials with several treatment groups or outcomes while controlling the chance of any false positive.

In plain words
What is it for?
Use it to select and compare multiplicity-adjustment procedures, tune their parameters, and perform sensitivity analyses for multi-arm or multi-endpoint trials.
Why use it?
It helps avoid choosing a method that produces too many false findings or reduces the study's ability to detect real effects. It also provides a rationale and checks how the choice behaves in different scenarios.

Command

Part of the clinical-trial-simulation plugin — 7 skills, 5 commands, 7 agents shipped together

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add commands/choxos/biostatagent/multiplicity-optimization
Clone the repo
git clone --depth 1 https://github.com/choxos/BiostatAgent

Or install clinical-trial-simulation, the plugin that ships this one along with the rest of its 7 skills, 5 commands, 7 agents.

Per session 17 Only the description is in the session, so the agent can decide to use it. The body loads when it is invoked.
When invoked 639 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. Scan, not verified.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5 $0.00017 $0.00639
Opus 5 $0.00009 $0.00319
Sonnet 5 $0.00003 $0.00128
Haiku 4.5 $0.00002 $0.00064

Measured 3d ago against content hash 4475ff9417d0, method: parsed. Prices are Anthropic first-party input rates as of 2026-08-30, from the pricing page.

Security

Grade A, and why

multiplicity-optimization scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 3d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

plugins/clinical-trial-simulation/commands/multiplicity-optimization.md · 97 lines

How it starts

The opening of the file, as written. The whole thing — 97 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Multiplicity Optimization Workflow

Overview

Select and optimize multiplicity adjustment procedures for multi-arm or multi-endpoint trials while controlling FWER and maximizing power.

Workflow Phases

Phase 1: Hypothesis Structure

Phase 2: Procedure Selection

Phase 3: Optimization

Phase 4: Sensitivity Analysis

Success Criteria

  • FWER controlled at alpha under all null configurations
  • Power optimized for primary objective
  • Procedure robust across scenarios
  • Clear rationale for recommendation

Read the full file on GitHub · 97 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 3d ago First seen · 97 lines · 17 tokens per session scan A 4475ff9417d0

Subscribe to this mod's changes

multiplicity-optimization is a command published in the GitHub repository choxos/BiostatAgent (11 stars, last pushed 3mo ago), licensed MIT. It adds 17 tokens to every session and 639 once invoked, about $0.0001 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.