Heuris-BioMCP: Instructions file for Claude Code

CLAUDE.md

Heuris-BioMCP CLAUDE.md is an instructions file for Claude Code from SachinGawande2003/Heuris-BioMCP. It costs 988 tokens per session, scanned A, original, MIT.

Instruction notes for Heuris-BioMCP, a server that gives coding agents access to curated biomedical research and analysis tools. They cover literature searches, gene and protein information, pathways, mutations, disease links, CRISPR planning, and protein structures.

In plain words
What is it for?
Reviewing scientific literature, investigating genes and proteins, analysing biological pathways, assessing disease or cancer links, planning CRISPR work, and examining protein structures.
Why use it?
They give the agent a prescribed order of work and explain which source to use for different biomedical questions, reducing scattered or poorly grounded research.

Instructions file for Claude Code

Written for Claude Code: the file is CLAUDE.md.

This is SachinGawande2003/Heuris-BioMCP's own configuration. It tells Claude Code how to work on Heuris-BioMCP itself, so it is not a mod to install elsewhere. Copy it as a starting point and replace the rules that are about this project. Everything Heuris-BioMCP configures →

Reuse

Borrowing it

Nothing to install: this file belongs to SachinGawande2003/Heuris-BioMCP. Take a copy, put it at the same path in your own repository, and replace the rules that are about this project with yours.

Copy the file
curl -O https://raw.githubusercontent.com/SachinGawande2003/Heuris-BioMCP/master/CLAUDE.md
Clone the repo
git clone --depth 1 https://github.com/SachinGawande2003/Heuris-BioMCP

Made for: Claude Code.

Wrote this? Show the measurements

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README.md
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Per session 988 This file is loaded in full into every session.
When invoked 988 The same file — it is already loaded in full.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00988 $0.00988
Opus 5 $0.00494 $0.00494
Sonnet 5 $0.00198 $0.00198
Haiku 4.5 $0.00099 $0.00099

Measured 11d ago against content hash 398dd68e3e6a, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

Heuris-BioMCP CLAUDE.md scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 11d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

CLAUDE.md · 110 lines

How it starts

The opening of the file, as written. The whole thing — 110 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Heuris-BioMCP Agent Guidance

What this server is for

Heuris-BioMCP exposes a curated bioinformatics MCP surface for literature review, gene and protein lookup, pathway analysis, translational research, CRISPR planning, variant interpretation, and biomedical strategy workflows.

The public tool list is intentionally curated. Prefer the higher-level workflow tools when they match the task instead of stitching together many low-level calls.

Literature and mechanism grounding

Start with:

  • search_pubmed for the evidence base
  • get_gene_info for canonical gene context
  • get_protein_info or find_protein for protein-level detail
  • pathway_analysis for pathway and mechanism context

Translational gene review

Use:

  • multi_omics_gene_report for a broad cross-database synthesis
  • search_cbio_mutations for cancer mutation context
  • search_gwas_catalog for trait associations
  • get_gene_disease_associations for disease links

Protein structure work

Use:

  • find_protein to resolve a protein or accession
  • get_alphafold_structure for public structure models
  • predict_structure_boltz2 only when NVIDIA credentials are configured
  • protein_binding_pocket or structural_similarity for follow-on structure analysis

CRISPR design and review

Use:

  • crispr_analysis with action="design" for guide design
  • crispr_analysis with action="off_target" for off-target review
  • crispr_analysis with action="repair" for repair template workflows

Variant interpretation

Use:

  • variant_analysis with action="full_report" for a full interpretation pass
  • variant_analysis with action="clinvar" or action="population_frequency" for narrow follow-ups
  • rare_disease_diagnosis when the entry point is phenotype-first rather than variant-first

Drug and biomarker work

Use:

  • get_drug_targets and find_repurposing_candidates for target and repurposing ideas
  • drug_interaction_checker for interaction checks
  • drug_safety for safety and labeling workflows
  • biomarker_panel_design and pharmacogenomics_report for translational planning

Read the full file on GitHub · 110 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 11d ago First seen · 110 lines · 988 tokens per session scan A 398dd68e3e6a

Subscribe to this mod's changes

Heuris-BioMCP CLAUDE.md is an instructions file published in the GitHub repository SachinGawande2003/Heuris-BioMCP (1 stars, last pushed 5mo ago), licensed MIT. It adds 988 tokens to every session, about $0.0049 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-31.

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