geniml

geniml is a skill for Claude Code, Codex from AndyZhuang/Opentest. It costs 89 tokens per session (2,521 once invoked), scanned A, a copy of geniml, MIT.

A Python toolkit for machine-learning work on genomic intervals, which are regions of DNA commonly stored in BED files. It can turn regions, cells, and labels into numerical representations for analysis.

In plain words
What is it for?
Use it to learn region embeddings, analyze single-cell ATAC-seq data, build shared peak sets, cluster regions, and support similarity searches.
Why use it?
It makes large collections of DNA regions easier to compare, group, search, and use in machine-learning models.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to learn region embeddings, analyze single-cell ATAC-seq data, build shared peak sets, cluster regions, and support similarity searches.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/andyzhuang/opentest/geniml
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AndyZhuang/Opentest --skill geniml
Clone the repo
git clone --depth 1 https://github.com/AndyZhuang/Opentest

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for geniml

README.md
[![agentmods](https://agentmods.dev/badge/skills/andyzhuang/opentest/geniml/github.svg)](https://agentmods.dev/skills/andyzhuang/opentest/geniml)
Your own site
<a href="https://agentmods.dev/skills/andyzhuang/opentest/geniml"><img src="https://agentmods.dev/badge/skills/andyzhuang/opentest/geniml/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for geniml

Your own site · 80×15
<a href="https://agentmods.dev/skills/andyzhuang/opentest/geniml"><img src="https://agentmods.dev/badge/skills/andyzhuang/opentest/geniml.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 89 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,521 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin 81% copy Near-identical to another mod in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00089 $0.02521
Opus 5 $0.00044 $0.01260
Sonnet 5 $0.00018 $0.00504
Haiku 4.5 $0.00009 $0.00252

Measured 9d ago against content hash 26add5a2f4cb, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-09, from the pricing page.

Security

Grade A, and why

geniml scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

This is a copy

81% identical to geniml — 6 lines differ, which has more behind it and is treated as the original. This page carries a canonical link to it rather than competing with it.

skills/labclaw/bio/geniml/SKILL.md · 318 lines

How it starts

The opening of the file, as written. The whole thing — 318 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Geniml: Genomic Interval Machine Learning

Overview

Geniml is a Python package for building machine learning models on genomic interval data from BED files. It provides unsupervised methods for learning embeddings of genomic regions, single cells, and metadata labels, enabling similarity searches, clustering, and downstream ML tasks.

Installation

Install geniml using uv:

uv uv pip install geniml

For ML dependencies (PyTorch, etc.):

uv uv pip install 'geniml[ml]'

Development version from GitHub:

uv uv pip install git+https://github.com/databio/geniml.git

Core Capabilities

Geniml provides five primary capabilities, each detailed in dedicated reference files:

1. Region2Vec: Genomic Region Embeddings

Train unsupervised embeddings of genomic regions using word2vec-style learning.

Use for: Dimensionality reduction of BED files, region similarity analysis, feature vectors for downstream ML.

Workflow:

  1. Tokenize BED files using a universe reference
  2. Train Region2Vec model on tokens
  3. Generate embeddings for regions

Reference: See references/region2vec.md for detailed workflow, parameters, and examples.

2. BEDspace: Joint Region and Metadata Embeddings

Train shared embeddings for region sets and metadata labels using StarSpace.

Use for: Metadata-aware searches, cross-modal queries (region→label or label→region), joint analysis of genomic content and experimental conditions.

Workflow:

  1. Preprocess regions and metadata
  2. Train BEDspace model
  3. Compute distances
  4. Query across regions and labels

Reference: See references/bedspace.md for detailed workflow, search types, and examples.

3. scEmbed: Single-Cell Chromatin Accessibility Embeddings

Train Region2Vec models on single-cell ATAC-seq data for cell-level embeddings.

Use for: scATAC-seq clustering, cell-type annotation, dimensionality reduction of single cells, integration with scanpy workflows.

Workflow:

  1. Prepare AnnData with peak coordinates
  2. Pre-tokenize cells
  3. Train scEmbed model
  4. Generate cell embeddings
  5. Cluster and visualize with scanpy

Read the full file on GitHub · 318 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 318 lines · 89 tokens per session scan A 26add5a2f4cb

Subscribe to this mod's changes

geniml is a skill published in the GitHub repository AndyZhuang/Opentest (22 stars, last pushed 6mo ago), licensed MIT. It adds 89 tokens to every session and 2,521 once invoked, about $0.0004 per session on Opus 5. A static security scan graded it A with 0 findings. It is 81% identical to geniml, differing in 6 lines, and is treated as a copy.

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