tooluniverse-clinical-trial-matching

tooluniverse-clinical-trial-matching is a skill for Claude Code, Codex from AndyZhuang/Opentest. It costs 128 tokens per session (12,982 once invoked), scanned A, original, MIT.

A patient-to-trial matching workflow that searches ClinicalTrials.gov, a public registry of clinical studies. It compares a patient's disease, stage, treatments, and molecular changes with trial eligibility rules.

In plain words
What is it for?
It is for finding and prioritizing oncology and precision-medicine trials, checking eligibility, and presenting enrollment details and next steps.
Why use it?
It narrows a large trial list into ranked matches and shows how well each study fits the patient profile.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit It is for finding and prioritizing oncology and precision-medicine trials, checking eligibility, and presenting enrollment details and next steps.

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Install with agentmods
npx agentmods add skills/andyzhuang/opentest/tooluniverse-clinical-trial-matching
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AndyZhuang/Opentest --skill tooluniverse-clinical-trial-matching
Clone the repo
git clone --depth 1 https://github.com/AndyZhuang/Opentest

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for tooluniverse-clinical-trial-matching

README.md
[![agentmods](https://agentmods.dev/badge/skills/andyzhuang/opentest/tooluniverse-clinical-trial-matching/github.svg)](https://agentmods.dev/skills/andyzhuang/opentest/tooluniverse-clinical-trial-matching)
Your own site
<a href="https://agentmods.dev/skills/andyzhuang/opentest/tooluniverse-clinical-trial-matching"><img src="https://agentmods.dev/badge/skills/andyzhuang/opentest/tooluniverse-clinical-trial-matching/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for tooluniverse-clinical-trial-matching

Your own site · 80×15
<a href="https://agentmods.dev/skills/andyzhuang/opentest/tooluniverse-clinical-trial-matching"><img src="https://agentmods.dev/badge/skills/andyzhuang/opentest/tooluniverse-clinical-trial-matching.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 128 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 12,982 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00128 $0.12982
Opus 5 $0.00064 $0.06491
Sonnet 5 $0.00026 $0.02596
Haiku 4.5 $0.00013 $0.01298

Measured 9d ago against content hash 39ac127cf2d5, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

tooluniverse-clinical-trial-matching scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/labclaw/med/tooluniverse-clinical-trial-matching/SKILL.md · 1,334 lines

How it starts

The opening of the file, as written. The whole thing — 1,334 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Clinical Trial Matching for Precision Medicine

Transform patient molecular profiles and clinical characteristics into prioritized clinical trial recommendations. Searches ClinicalTrials.gov and cross-references with molecular databases (CIViC, OpenTargets, ChEMBL, FDA) to produce evidence-graded, scored trial matches.

KEY PRINCIPLES:

  1. Report-first approach - Create report file FIRST, then populate progressively
  2. Patient-centric - Every recommendation considers the individual patient's profile
  3. Molecular-first matching - Prioritize trials targeting patient's specific biomarkers
  4. Evidence-graded - Every recommendation has an evidence tier (T1-T4)
  5. Quantitative scoring - Trial Match Score (0-100) for every trial
  6. Eligibility-aware - Parse and evaluate inclusion/exclusion criteria
  7. Actionable output - Clear next steps, contact info, enrollment status
  8. Source-referenced - Every statement cites the tool/database source
  9. Completeness checklist - Mandatory section showing analysis coverage
  10. English-first queries - Always use English terms in tool calls. Respond in user's language

When to Use

Apply when user asks:

  • "What clinical trials are available for my NSCLC with EGFR L858R?"
  • "Patient has BRAF V600E melanoma, failed ipilimumab - what trials?"
  • "Find basket trials for NTRK fusion"
  • "Breast cancer with HER2 amplification, post-CDK4/6 inhibitor trials"
  • "KRAS G12C colorectal cancer clinical trials"
  • "Immunotherapy trials for TMB-high solid tumors"
  • "Clinical trials near Boston for lung cancer"
  • "What are my options after failing osimertinib for EGFR+ NSCLC?"

NOT for (use other skills instead):

  • Single variant interpretation without trial focus -> Use tooluniverse-cancer-variant-interpretation
  • Drug safety profiling -> Use tooluniverse-adverse-event-detection
  • Target validation -> Use tooluniverse-drug-target-validation
  • General disease research -> Use tooluniverse-disease-research

Read the full file on GitHub · 1,334 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 1,334 lines · 128 tokens per session scan A 39ac127cf2d5

Subscribe to this mod's changes

tooluniverse-clinical-trial-matching is a skill published in the GitHub repository AndyZhuang/Opentest (22 stars, last pushed 6mo ago), licensed MIT. It adds 128 tokens to every session and 12,982 once invoked, about $0.0006 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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