tooluniverse-immunotherapy-response-prediction

tooluniverse-immunotherapy-response-prediction is a skill for Claude Code, Codex from AndyZhuang/Opentest. It costs 161 tokens per session (9,677 once invoked), scanned A, original, MIT.

A method for estimating how likely a cancer patient is to respond to immune checkpoint inhibitors, a type of cancer immunotherapy. It combines tumor mutations and biomarkers such as TMB, PD-L1, and MSI.

In plain words
What is it for?
It is for producing response scores, drug-specific recommendations, resistance-risk assessments, and monitoring plans.
Why use it?
It brings several response and resistance signals together and records the evidence behind the assessment.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit It is for producing response scores, drug-specific recommendations, resistance-risk assessments, and monitoring plans.

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Install with agentmods
npx agentmods add skills/andyzhuang/opentest/tooluniverse-immunotherapy-response-prediction
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AndyZhuang/Opentest --skill tooluniverse-immunotherapy-response-prediction
Clone the repo
git clone --depth 1 https://github.com/AndyZhuang/Opentest

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for tooluniverse-immunotherapy-response-prediction

README.md
[![agentmods](https://agentmods.dev/badge/skills/andyzhuang/opentest/tooluniverse-immunotherapy-response-prediction/github.svg)](https://agentmods.dev/skills/andyzhuang/opentest/tooluniverse-immunotherapy-response-prediction)
Your own site
<a href="https://agentmods.dev/skills/andyzhuang/opentest/tooluniverse-immunotherapy-response-prediction"><img src="https://agentmods.dev/badge/skills/andyzhuang/opentest/tooluniverse-immunotherapy-response-prediction/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for tooluniverse-immunotherapy-response-prediction

Your own site · 80×15
<a href="https://agentmods.dev/skills/andyzhuang/opentest/tooluniverse-immunotherapy-response-prediction"><img src="https://agentmods.dev/badge/skills/andyzhuang/opentest/tooluniverse-immunotherapy-response-prediction.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 161 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 9,677 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00161 $0.09677
Opus 5 $0.00081 $0.04838
Sonnet 5 $0.00032 $0.01935
Haiku 4.5 $0.00016 $0.00968

Measured 9d ago against content hash ad0512b70152, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

tooluniverse-immunotherapy-response-prediction scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/labclaw/med/tooluniverse-immunotherapy-response-prediction/SKILL.md · 866 lines

How it starts

The opening of the file, as written. The whole thing — 866 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Immunotherapy Response Prediction

Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Transforms a patient tumor profile (cancer type + mutations + biomarkers) into a quantitative ICI Response Score with drug-specific recommendations, resistance risk assessment, and monitoring plan.

KEY PRINCIPLES:

  1. Report-first approach - Create report file FIRST, then populate progressively
  2. Evidence-graded - Every finding has an evidence tier (T1-T4)
  3. Quantitative output - ICI Response Score (0-100) with transparent component breakdown
  4. Cancer-specific - All thresholds and predictions are cancer-type adjusted
  5. Multi-biomarker - Integrate TMB + MSI + PD-L1 + neoantigen + mutations
  6. Resistance-aware - Always check for known resistance mutations (STK11, PTEN, JAK1/2, B2M)
  7. Drug-specific - Recommend specific ICI agents with evidence
  8. Source-referenced - Every statement cites the tool/database source
  9. English-first queries - Always use English terms in tool calls

When to Use

Apply when user asks:

  • "Will this patient respond to immunotherapy?"
  • "Should I give pembrolizumab to this melanoma patient?"
  • "Patient has NSCLC with TMB 25, PD-L1 80% - predict ICI response"
  • "MSI-high colorectal cancer - which checkpoint inhibitor?"
  • "Patient has BRAF V600E melanoma, TMB 15 - immunotherapy or targeted?"
  • "Low TMB NSCLC with STK11 mutation - should I try immunotherapy?"
  • "Compare pembrolizumab vs nivolumab for this patient profile"
  • "What biomarkers predict checkpoint inhibitor response?"

Input Parsing

Required: Cancer type + at least one of: mutation list OR TMB value Optional: PD-L1 expression, MSI status, immune infiltration data, HLA type, prior treatments, intended ICI

Accepted Input Formats

Format Example How to Parse
Cancer + mutations "Melanoma, BRAF V600E, TP53 R273H" cancer=melanoma, mutations=[BRAF V600E, TP53 R273H]
Cancer + TMB "NSCLC, TMB 25 mut/Mb" cancer=NSCLC, tmb=25
Cancer + full profile "Melanoma, BRAF V600E, TMB 15, PD-L1 50%, MSS" cancer=melanoma, mutations=[BRAF V600E], tmb=15, pdl1=50, msi=MSS
Cancer + MSI status "Colorectal cancer, MSI-high" cancer=CRC, msi=MSI-H
Resistance query "NSCLC, TMB 2, STK11 loss, PD-L1 <1%" cancer=NSCLC, tmb=2, mutations=[STK11 loss], pdl1=0
ICI selection "Which ICI for NSCLC PD-L1 90%?" cancer=NSCLC, pdl1=90, query_type=drug_selection

Read the full file on GitHub · 866 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 866 lines · 161 tokens per session scan A ad0512b70152

Subscribe to this mod's changes

tooluniverse-immunotherapy-response-prediction is a skill published in the GitHub repository AndyZhuang/Opentest (22 stars, last pushed 6mo ago), licensed MIT. It adds 161 tokens to every session and 9,677 once invoked, about $0.0008 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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