tooluniverse-spatial-omics-analysis

tooluniverse-spatial-omics-analysis is a skill for Claude Code, Codex from AndyZhuang/Opentest. It costs 178 tokens per session (11,803 once invoked), scanned A, original, MIT.

A workflow for interpreting spatial multi-omics data, which combines measurements of genes, proteins, and other molecules with their locations in tissue. It examines spatial regions, biological pathways, cell interactions, disease mechanisms, and possible treatment targets.

In plain words
What is it for?
Use it to analyze spatially variable genes and tissue regions from platforms such as 10x Visium, MERFISH, DBiTplus, or Slide-seq. It can support pathway analysis, cell-interaction studies, immune-environment analysis, drug-target discovery, and integration of multiple molecular data types.
Why use it?
It turns complex spatial biology results into biological explanations, while keeping findings tied to data sources and grading the strength of evidence. It also helps identify ways to validate important results experimentally.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one. Also seen: mentions Codex.

Good fit Use it to analyze spatially variable genes and tissue regions from platforms such as 10x Visium, MERFISH, DBiTplus, or Slide-seq. It can support pathway analysis, cell-interaction studies, immune-environment analysis, drug-target discovery, and integration of multiple molecular data types.

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Install with agentmods
npx agentmods add skills/andyzhuang/opentest/tooluniverse-spatial-omics-analysis
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AndyZhuang/Opentest --skill tooluniverse-spatial-omics-analysis
Clone the repo
git clone --depth 1 https://github.com/AndyZhuang/Opentest

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for tooluniverse-spatial-omics-analysis

README.md
[![agentmods](https://agentmods.dev/badge/skills/andyzhuang/opentest/tooluniverse-spatial-omics-analysis/github.svg)](https://agentmods.dev/skills/andyzhuang/opentest/tooluniverse-spatial-omics-analysis)
Your own site
<a href="https://agentmods.dev/skills/andyzhuang/opentest/tooluniverse-spatial-omics-analysis"><img src="https://agentmods.dev/badge/skills/andyzhuang/opentest/tooluniverse-spatial-omics-analysis/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for tooluniverse-spatial-omics-analysis

Your own site · 80×15
<a href="https://agentmods.dev/skills/andyzhuang/opentest/tooluniverse-spatial-omics-analysis"><img src="https://agentmods.dev/badge/skills/andyzhuang/opentest/tooluniverse-spatial-omics-analysis.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 178 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 11,803 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00178 $0.11803
Opus 5 $0.00089 $0.05901
Sonnet 5 $0.00036 $0.02361
Haiku 4.5 $0.00018 $0.01180

Measured 8d ago against content hash 0ac769ceb6ea, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-11, from the pricing page.

Security

Grade A, and why

tooluniverse-spatial-omics-analysis scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 8d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/labclaw/bio/tooluniverse-spatial-omics-analysis/SKILL.md · 1,103 lines

How it starts

The opening of the file, as written. The whole thing — 1,103 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Spatial Multi-Omics Analysis Pipeline

Comprehensive biological interpretation of spatial omics data. Transforms spatially variable genes (SVGs), domain annotations, and tissue context into actionable biological insights covering pathway enrichment, cell-cell interactions, druggable targets, immune microenvironment, and multi-modal integration.

KEY PRINCIPLES:

  1. Report-first approach - Create report file FIRST, then populate progressively
  2. Domain-by-domain analysis - Characterize each spatial region independently before comparison
  3. Gene-list-centric - Analyze user-provided SVGs and marker genes with ToolUniverse databases
  4. Biological interpretation - Go beyond statistics to explain biological meaning of spatial patterns
  5. Disease focus - Emphasize disease mechanisms and therapeutic opportunities when disease context is provided
  6. Evidence grading - Grade all evidence as T1 (human/clinical) to T4 (computational)
  7. Multi-modal thinking - Integrate RNA, protein, and metabolite information when available
  8. Validation guidance - Suggest experimental validation approaches for key findings
  9. Source references - Every statement must cite tool/database source
  10. Completeness checklist - Mandatory section showing analysis coverage
  11. English-first queries - Always use English terms in tool calls. Respond in user's language

When to Use This Skill

Apply when users:

  • Provide spatially variable genes from spatial transcriptomics experiments
  • Ask about biological interpretation of spatial domains/clusters
  • Need pathway enrichment analysis of spatial gene expression data
  • Want to understand cell-cell interactions from spatial data
  • Ask about tumor microenvironment heterogeneity from spatial omics
  • Need druggable targets in specific spatial regions
  • Ask about tissue zonation patterns (liver, brain, kidney)
  • Want to integrate spatial transcriptomics + proteomics data
  • Ask about immune infiltration patterns from spatial data
  • Need to compare healthy vs disease regions spatially
  • Ask "What pathways are enriched in this tumor core vs tumor margin?"
  • Ask "What cell-cell interactions occur in this spatial domain?"

Read the full file on GitHub · 1,103 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 8d ago First seen · 1,103 lines · 178 tokens per session scan A 0ac769ceb6ea

Subscribe to this mod's changes

tooluniverse-spatial-omics-analysis is a skill published in the GitHub repository AndyZhuang/Opentest (22 stars, last pushed 6mo ago), licensed MIT. It adds 178 tokens to every session and 11,803 once invoked, about $0.0009 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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