scientific-problem-selection

A conversational framework for choosing scientific research problems and deciding how to pursue them. It is based on a 2024 Cell paper about problem choice and decision trees in science and engineering.

In plain words
What is it for?
Use it to develop a new project idea, troubleshoot a current research problem, evaluate project risks, or make a strategic scientific decision.
Why use it?
It helps turn an early idea, a stuck project, or a strategic question into a clearer research direction while considering plans and risks.

Skill for Claude CodeCodex

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add skills/anthropics/knowledge-work-plugins/scientific-problem-selection
Any agent
npx skills add anthropics/knowledge-work-plugins --skill scientific-problem-selection
Clone the repo
git clone --depth 1 https://github.com/anthropics/knowledge-work-plugins

Made for: Claude Code, Codex.

Per session 118 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,552 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. Scan, not verified.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5 $0.00118 $0.02552
Opus 5 $0.00059 $0.01276
Sonnet 5 $0.00024 $0.00510
Haiku 4.5 $0.00012 $0.00255

Measured 2d ago against content hash 9ec99e3e5b2f, method: parsed. Prices are Anthropic first-party input rates as of 2026-08-30, from the pricing page.

Security

Grade A, and why

scientific-problem-selection scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 2d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

Copies of this mod

3 near-identical copies found in the catalogue:

bio-research/skills/scientific-problem-selection/SKILL.md · 270 lines

How it starts

The opening of the file, as written. The whole thing — 270 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Scientific Problem Selection Skills

A conversational framework for systematic scientific problem selection based on Fischbach & Walsh's "Problem choice and decision trees in science and engineering" (Cell, 2024).

Getting Started

Present users with three entry points:

1) Pitch an idea for a new project — to work it up together

2) Share a problem in a current project — to troubleshoot together

3) Ask a strategic question — to navigate the decision tree together

This conversational entry meets scientists where they are and establishes a collaborative tone.


Option 1: Pitch an Idea

Initial Prompt

Ask: "Tell me the short version of your idea (1-2 sentences)."

Response Approach

After the user shares their idea, return a quick summary (no more than one paragraph) demonstrating understanding. Note the general area of research and rephrase the idea in a way that highlights its kernel—showing alignment and readiness to dive into details.

Follow-up Prompt

Then ask for more detail: "Now give me a bit more detail. You might include, however briefly or even say where you are unsure:

  1. What exactly you want to do
  2. How you currently plan to do it
  3. If it works, why will it be a big deal
  4. What you think are the major risks"

Workflow

From there, guide the user through the early stages of problem selection and evaluation:

  • Skill 1: Intuition Pumps - Refine and strengthen the idea
  • Skill 2: Risk Assessment - Identify and manage project risks
  • Skill 3: Optimization Function - Define success metrics
  • Skill 4: Parameter Strategy - Determine what to fix vs. keep flexible

See references/01-intuition-pumps.md, references/02-risk-assessment.md, references/03-optimization-function.md, and references/04-parameter-strategy.md for detailed guidance.


Option 2: Troubleshoot a Problem

Initial Prompt

Ask: "Tell me a short version of your problem (1-2 sentences or whatever is easy)."

Response Approach

After the user shares their problem, return a quick summary (no more than one paragraph) demonstrating understanding. Note the context of the project where the problem occurred and rephrase the problem—highlighting its core essence—so the user knows the situation is understood. Also raise additional questions that seem important to discuss.

Read the full file on GitHub · 270 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 2d ago First seen · 270 lines · 118 tokens per session scan A 9ec99e3e5b2f

Subscribe to this mod's changes

scientific-problem-selection is a skill published in the GitHub repository anthropics/knowledge-work-plugins (23,791 stars, last pushed today), licensed Apache-2.0. It adds 118 tokens to every session and 2,552 once invoked, about $0.0006 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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