What is binder-gauntlet?

A validation and developability workflow for computer-designed protein binders and miniproteins aimed at a protein target. It independently re-predicts structures, checks agreement between binding poses, and performs additional validation beyond structure-prediction confidence scores.

Use it to evaluate designed binders with independent predictions, DockQ pose comparison, controls, developability checks, and a validation dossier.

It helps distinguish promising designs from candidates supported only by scores such as ipSAE, ipTM, or pAE.

binder-gauntlet — Skill for Claude Code and Codex by anthropics

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent

npx skills add anthropics/life-sciences --skill binder-gauntlet

Clone the repo

git clone --depth 1 https://github.com/anthropics/life-sciences

Made for: Claude Code, Codex.

Its marketplace also offers this one on its own, as the plugin binder-gauntlet — /plugin install binder-gauntlet after adding the marketplace above.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

README.md

[![agentmods](https://agentmods.dev/badge/skills/anthropics/life-sciences/binder-gauntlet/github.svg)](https://agentmods.dev/skills/anthropics/life-sciences/binder-gauntlet)

Your own site

<a href="https://agentmods.dev/skills/anthropics/life-sciences/binder-gauntlet"><img src="https://agentmods.dev/badge/skills/anthropics/life-sciences/binder-gauntlet/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

Your own site · 80×15

<a href="https://agentmods.dev/skills/anthropics/life-sciences/binder-gauntlet"><img src="https://agentmods.dev/badge/skills/anthropics/life-sciences/binder-gauntlet.svg" alt="Reviewed on agentmods" width="80" height="20"></a>

Per session 176 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.

When invoked 3,470 The whole file, excluding the scripts and references it only reads on demand.

Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.

Origin unknown No closer match found in the catalogue.

Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

Model	Per session	Once invoked
Fable 5.1	$0.00176	$0.03470
Opus 5.5	$0.00070	$0.01388
Sonnet 5.5	$0.00035	$0.00694
Haiku 4.5	$0.00018	$0.00347

Measured 7d ago against content hash ff9e88ea2825, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

binder-gauntlet scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 7d ago.

The scan reads SKILL.md. This mod also ships 2 executable files (sample/fetch-sample.sh, scripts/sequence_profile.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

binder-gauntlet/SKILL.md · 59 lines

The source is not reproduced here

No licence file

Read it on GitHub

Files

What ships with it

18 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

7d ago First seen · 59 lines · 176 tokens per session scan A ff9e88ea2825

Subscribe to this mod's changes

binder-gauntlet is a skill published in the GitHub repository anthropics/life-sciences (645 stars, last pushed yesterday), with no licence file. It adds 176 tokens to every session and 3,470 once invoked, about $0.0007 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-11-03.

Scientific

binder-gauntlet next to 6 skills from other repositories
Mod	Type	Stars	Last push	Licence	Scan	Tokens	Works with
binder-gauntletanthropics/life-sciences	Skill	645	yesterday	none	A	176	Claude Code, Codex
instrument-data-to-allotropeanthropics/knowledge-work-plugins	Skill	35k	3d ago	Apache-2.0	A	123	Claude Code
matlabK-Dense-AI/scientific-agent-skills	Skill	57k	yesterday	MIT	A	44	Claude Code
exploratory-data-analysisK-Dense-AI/scientific-agent-skills	Skill	57k	yesterday	MIT	A	83	Claude Code
phylogeneticsK-Dense-AI/scientific-agent-skills	Skill	57k	yesterday	MIT	A	71	Claude Code, Codex
research-engineerdavila7/claude-code-templates	Skill	33k	yesterday	MIT	A	43	Claude Code, Codex
mapping-to-snomedmaziyarpanahi/openmed	Skill	5.8k	yesterday	Apache-2.0	A	205	Claude Code