Open-source healthcare AI agent skills and life sciences agent skills. 42 skills for medical coding, risk adjustment, claims analytics, quality measures, genomics, imaging, and drug discovery across 13 HCLS domains.
awslabs/hcls-agent-skills is a collection of reusable instructions that help AI agents handle healthcare and life sciences work, including genomics, medical imaging, claims, and drug discovery. It is intended for agents running on Agent Skills-compatible platforms, and the catalogue entries are its individual domain skills.
Skill Claude CodeCodex ✓ vendor
Reasoning skill for designing AWS GenAI and ML architectures for healthcare and life sciences workloads. Use when the user asks to choose between SageMaker and Bedrock, design a RAG system over medical literature, architect clinical NLP or medical imaging inference, plan genomics or drug discovery pipelines on AWS…
Skill Claude CodeCodex ✓ vendor
Reason about biomarker discovery and validation in HCLS — classifying biomarker intent, choosing feature-selection and cross-validation strategies, avoiding leakage, and planning external replication. Use when the user asks to discover, develop, or validate a biomarker; select features from high-dimensional omics or…
Skill Claude CodeCodex ✓ vendor
Reason about CDISC SDTM and ADaM implementation for regulatory submissions. Use when the user asks about SDTM domain mapping, ADaM dataset design, controlled terminology versioning, define.xml completeness, FDA or PMDA submission requirements, query prioritization by clinical impact, SUPPQUAL usage, or CDISC…
Skill Claude CodeCodex ✓ vendor
Generate code to assign cell type labels to single-cell RNA-seq clusters using CellTypist, SingleR, marker-based annotation, or reference label transfer (scANVI/ingest). Triggers on requests to "annotate cell types", "label clusters", "run CellTypist", "SingleR annotation", "marker gene dotplot", "transfer labels from…
Skill Claude CodeCodex ✓ vendor
Cheminformatics pipeline for small-molecule property calculation, filtering, and similarity analysis using RDKit. Use when the user asks to compute molecular descriptors, filter compounds by Lipinski or Veber rules, detect PAINS, calculate fingerprint similarity, run matched molecular pair analysis, generate ADMET…
Skill Claude CodeCodex ✓ vendor
Pipeline skill for healthcare claims data parsing, analysis, and fraud detection. Use when the user asks to parse X12 837 or 835 claim files, manipulate ICD-10 CPT or HCPCS codes, detect billing pattern anomalies, profile providers against specialty peers, identify outlier billing behavior, validate NCCI edits…
Skill Claude CodeCodex ✓ vendor
Reasoning skill for healthcare claims billing rules and fraud detection logic. Use when the user asks about CMS billing rules, place of service codes, global surgery periods, modifier usage (25 59 76 77), NCCI edit logic, column 1 column 2 code pairs, mutually exclusive procedures, modifier indicators, fraud waste and…
Skill Claude CodeCodex ✓ vendor
Reason about clinical data terminology standards — MedDRA hierarchy (LLT→PT→HLT→HLGT→SOC), ICD-10 code structure and grouping, SNOMED CT concept model, LOINC panel relationships, and mapping decisions between systems. Use when the user asks to code adverse events, map diagnoses to ICD-10, choose a coding granularity…
Skill Claude CodeCodex ✓ vendor
DICOM and NIfTI medical image processing pipeline. Triggers on DICOM, NIfTI, dcm2niix, de-identification, pydicom, DICOM header, conversion, anonymization, BIDS, DICOM tags, medical image format conversion, "DICOM to NIfTI", "burned-in PHI", "SeriesInstanceUID", "nibabel", "DICOM anonymization".
Skill Claude CodeCodex ✓ vendor
Generate correct code for whole-slide image (WSI) analysis using TIAToolbox and foundation models (H-optimus-0, UNI, Prov-GigaPath). Triggers on requests involving whole-slide images, WSI, digital pathology, histopathology, SVS/NDPI/pyramidal TIFF, tissue segmentation, patch extraction, stain normalization…
Skill Claude CodeCodex ✓ vendor
Reason about drug repurposing strategies in HCLS — choosing between target-based and phenotype-based approaches, evaluating mechanism-of-action overlap, querying drug-gene interaction databases, assessing clinical translatability, and ranking candidates by evidence strength. Use when the user asks to repurpose a drug…
Skill Claude CodeCodex ✓ vendor
Generate code for EDC export validation, clinical data range checks, cross-form consistency checks, SDTM structure validation, controlled terminology verification, and define.xml generation. Use when the user asks to validate clinical trial data exports, check vital sign or lab value ranges, verify AE date…
Skill Claude CodeCodex ✓ vendor
Parse and extract clinical data from HL7v2 messages and FHIR R4 resources using Python. Use when the user mentions HL7v2, HL7, FHIR, PID segment, OBX segment, MSH segment, Patient resource, Observation resource, Condition resource, MedicationRequest, EHR data extraction, clinical message parsing, FHIR bundle, HL7 to…
Skill Claude CodeCodex ✓ vendor
Reason about germline and somatic variant classification using ACMG/AMP 2015 and AMP/ASCO/CAP frameworks. Use when the user asks to classify a variant, interpret a VCF annotation, resolve a VUS, apply ACMG criteria, weigh ClinVar evidence, evaluate gnomAD allele frequencies, interpret REVEL/CADD/SpliceAI scores…
Skill Claude CodeCodex ✓ vendor
Reasoning skill for HEDIS measure specification, enrollment logic, exclusion evaluation, NCQA audit requirements, and care gap prioritization. Use when the user asks about HEDIS measure definitions, denominator/numerator/exclusion logic, continuous enrollment rules, Star Rating impact, or care gap closure strategies.
Skill Claude CodeCodex ✓ vendor
Reasoning skill for medical imaging study design and biomarker selection. Use when the user asks to plan an imaging study, choose a preprocessing strategy, select an imaging biomarker, design a radiomics pipeline, handle DICOM de-identification, plan longitudinal imaging analysis, or pick a registration target.…
Skill Claude CodeCodex ✓ vendor
Reason about SaMD (Software as a Medical Device) regulatory compliance for FDA, EU MDR, and global submissions. Use when the user asks about IEC 62304 safety classification, ISO 14971 risk management, 21 CFR 820/QMSR quality system requirements, Design History File structure, 510(k)/De Novo/PMA pathway selection…
Skill Claude CodeCodex ✓ vendor
Reason about ML experiment design for healthcare and life sciences data. Use when the user asks to design an ML study, choose a model for clinical/biomedical data, set up cross-validation, pick evaluation metrics, audit fairness, plan a regulatory submission, or critique an ML pipeline on EHR, medical imaging…
Skill Claude CodeCodex ✓ vendor
Molecular docking pipeline using AutoDock Vina for structure-based drug discovery. Triggers on docking, AutoDock Vina, receptor preparation, ligand preparation, PDBQT, grid box, virtual screening, binding affinity, pose prediction, structure-based virtual screening, "redocking RMSD", "Vina score", "docking pose"…
Skill Claude CodeCodex ✓ vendor
Reasoning skill for multi-omics data integration strategy selection. Use when the user asks to integrate transcriptomics with proteomics, combine multi-omic layers, choose between early intermediate or late integration, apply batch correction across omics, handle partial sample overlap, run MOFA+ or iCluster…
Skill Claude CodeCodex ✓ vendor
Pipeline skill for multi-omics data processing and integration. Use when the user asks to map gene IDs between HGNC Ensembl and UniProt, convert between omic data formats, run batch correction with ComBat or ComBat-seq, perform GSEA or over-representation analysis on multi-omic results, run consensus clustering on…
Skill Claude CodeCodex ✓ vendor
NGS quality control pipeline for short-read sequencing data. Triggers on FastQC, QC, quality control, adapter trimming, coverage, mosdepth, Picard metrics, fastp, MultiQC, sequencing QC, BAM QC, WGS/WES coverage analysis.
Skill Claude CodeCodex ✓ vendor
Reasoning skill for prior authorization clinical policy evaluation. Use when the user asks about payer clinical criteria, step therapy requirements, medical necessity definitions, CMS LCD/NCD coverage rules, appeals documentation strategy, formulary tier implications, or FHIR Da Vinci PAS implementation guidance.…
Skill Claude CodeCodex ✓ vendor
Pipeline skill for automating prior authorization decision workflows. Use when the user asks to parse PA request data (X12 278 or FHIR PAS bundles), extract clinical features for adjudication, build rules-based PA decision engines, train ML classifiers on historical PA decisions, analyze denial patterns, or generate…
At most 3 mods per repository are shown here, and a mod shipped inside a plugin is left to that plugin's page — the rest are on their repository pages: