drug-response

drug-response is a skill for Claude Code from GGbond-bo/MemOmics-Agent. It costs 16 tokens per session (2,391 once invoked), scanned A, original, MIT.

A bioinformatics workflow for predicting how diseases or tumors may respond to drugs using gene-expression signatures, drug-sensitivity data, and combination-therapy analysis. IC50 is a measure of how much drug is needed to reduce a measured response by half.

In plain words
What is it for?
Use it for Connectivity Map analysis, IC50 prediction with oncoPredict, and drug-combination synergy analysis with DrugComb.
Why use it?
It brings several drug-response analyses together so you can compare candidate treatments and combinations in one workflow.

Skill for Claude Code

Written for Claude Code: when-to-use in frontmatter.

Good fit Use it for Connectivity Map analysis, IC50 prediction with oncoPredict, and drug-combination synergy analysis with DrugComb.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/ggbond-bo/memomics-agent/drug-response
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add GGbond-bo/MemOmics-Agent --skill drug-response
Clone the repo
git clone --depth 1 https://github.com/GGbond-bo/MemOmics-Agent

Made for: Claude Code.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for drug-response

README.md
[![agentmods](https://agentmods.dev/badge/skills/ggbond-bo/memomics-agent/drug-response/github.svg)](https://agentmods.dev/skills/ggbond-bo/memomics-agent/drug-response)
Your own site
<a href="https://agentmods.dev/skills/ggbond-bo/memomics-agent/drug-response"><img src="https://agentmods.dev/badge/skills/ggbond-bo/memomics-agent/drug-response/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for drug-response

Your own site · 80×15
<a href="https://agentmods.dev/skills/ggbond-bo/memomics-agent/drug-response"><img src="https://agentmods.dev/badge/skills/ggbond-bo/memomics-agent/drug-response.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 16 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,391 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00016 $0.02391
Opus 5 $0.00008 $0.01196
Sonnet 5 $0.00003 $0.00478
Haiku 4.5 $0.00002 $0.00239

Measured 9d ago against content hash 5f26aae34dc0, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

drug-response scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (scripts/run.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

hermes_home/skills/bioinformatics/drug-response/SKILL.md · 204 lines

How it starts

The opening of the file, as written. The whole thing — 204 lines — stays where its author put it; the contents beside it link to each section on GitHub.

药物响应预测

Connectivity Map+药物敏感性+联合用药预测

适用场景: disease, tumor, 有药敏数据

分析步骤:

  • Connectivity Map: cmapPy gene set enrichment
  • Drug sensitivity prediction: oncoPredict IC50
  • Combination therapy: DrugComb synergy

依赖包: pRRophetic, cmapPy, oncoPredict, GSVA

难度: advanced

触发提示: "预测药物响应"

When to Use

适用于: disease, tumor, 有药敏数据

Pipeline

  1. Connectivity Map
    • cmapPy gene set enrichment
    • Tool: terminal
  2. Drug sensitivity prediction
    • oncoPredict IC50
    • Tool: terminal
  3. Combination therapy
    • DrugComb synergy
    • Tool: terminal

Parameters

Parameter Default Notes
r_packages pRRophetic, oncoPredict, GSVA
python_packages cmapPy
steps Connectivity Map -> Drug sensitivity prediction -> Combination therapy

Parameter Adaptation: Adjust parameters based on tissue quality, species, and condition. Literature values take priority, then official defaults, then tissue-specific adjustments.

Proven Scripts

Scripts that have been successfully executed and passed analysis review. These are automatically saved after successful runs.

Species Tissue Condition Date Score
(none yet)

Common Issues

Error Cause Solution
(accumulated from runs)

References

  • Source: MemOmics built-in
  • Category: drug_discovery
  • Language: Python

🗣️ 辩论机制(debate_analysis)

本 skill 在执行后,如果涉及参数选择、方法决策、结果判断等不确定环节,必须调用 工具进行多角色辩论。

辩论规则

  • 正方 3 位专业编辑(各自独立,互相看不到):生物学编辑 / 统计学编辑 / 生信编辑
  • 反方 4 位专业编辑(各自独立,互相看不到,也看不到正方):生物学编辑 / 统计学编辑 / 生信编辑 / 历史经验编辑
  • 裁判:看到所有 7 方论点后给出裁决 + 置信度(高/中/低)
  • 上下文隔离:每个编辑是独立的 LLM API 调用,messages 只包含自己的 prompt

触发场景

  • 参数选择有多个合理选项时(如分辨率 0.4 vs 0.6 vs 0.8)
  • 结果可能受方法选择影响时(如不同注释方法给出不同结果)
  • 生物结论需要验证可靠性时
  • QC 阈值不确定时(如 MT% 阈值 10% vs 15% vs 20%)

Read the full file on GitHub · 204 lines

Files

What ships with it

2 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 204 lines · 16 tokens per session scan A 5f26aae34dc0

Subscribe to this mod's changes

drug-response is a skill published in the GitHub repository GGbond-bo/MemOmics-Agent (19 stars, last pushed 2d ago), licensed MIT. It adds 16 tokens to every session and 2,391 once invoked, about $0.0001 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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