sepsis-3-cohort

Sepsis-3 Cohort Identification

The Sepsis-3 definition (Singer et al. 2016) identifies sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection. This is a conceptual definition; the operationalization is a proxy:

• Suspected infection (antibiotics + culture within time window) AND
• SOFA score >= 2 (within 48h before to 24h after suspected infection)

Related Sepsis-3 Constructs

• qSOFA (quick SOFA): Bedside screening tool for patients outside the ICU (RR >= 22, altered mentation, SBP <= 100). Not a diagnostic criterion — meant to prompt further assessment. Sensitivity is limited; a negative qSOFA does not rule out sepsis.
• Septic Shock: Sepsis with vasopressor requirement to maintain MAP >= 65 mmHg AND lactate > 2 mmol/L despite adequate fluid resuscitation. Carries substantially higher mortality than sepsis alone.

M4Bench Use

In M4Bench, target concept tables listed in the task configuration are removed or unavailable in the agent database. Use this skill as procedural guidance and derive the requested output from available source or intermediate tables; do not rely on a precomputed target table or bundled SQL script.

When to Use This Skill

• Creating sepsis patient cohorts for research
• Sepsis outcome studies
• Quality improvement and benchmarking
• Comparing sepsis populations across studies
• Validating machine learning models on sepsis data

Sepsis-3 Definition Details

Suspected Infection Criteria

A patient has suspected infection when:

1. Antibiotics are administered (systemic, excluding topical) AND
2. Cultures are obtained within a time window:
   • Culture within 72h BEFORE antibiotic, OR
   • Culture within 24h AFTER antibiotic

See suspicion-of-infection for detailed matching logic.

SOFA Criteria

SOFA >= 2 points, where SOFA is calculated using 24-hour worst values:

• Must occur within 48h before to 24h after suspected infection time