What is folklore-clinical-variant-interpretation?

A coding-agent skill for interpreting one public germline genetic variant under ACMG/AMP guidelines. ACMG/AMP is a framework used by genetics professionals to assess evidence about whether a variant may affect health.

Use it to investigate variant classifications, VUS results, pathogenicity questions, HGVS or SPDI notation, rsIDs, genomic coordinates, and papers about a supported GRCh38 variant.

It provides a structured evidence review instead of guessing from memory, while preserving uncertainty and keeping patient information out of the request. The result is decision support, not a diagnosis or treatment recommendation.

folklore-clinical-variant-interpretat — Skill by helena-bioinformatics

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent

npx skills add helena-bioinformatics/folklore-mcp --skill folklore-clinical-variant-interpretation

Clone the repo

git clone --depth 1 https://github.com/helena-bioinformatics/folklore-mcp

Made for: Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

README.md

[![agentmods](https://agentmods.dev/badge/skills/helena-bioinformatics/folklore-mcp/folklore-clinical-variant-interpretation/github.svg)](https://agentmods.dev/skills/helena-bioinformatics/folklore-mcp/folklore-clinical-variant-interpretation)

Your own site

<a href="https://agentmods.dev/skills/helena-bioinformatics/folklore-mcp/folklore-clinical-variant-interpretation"><img src="https://agentmods.dev/badge/skills/helena-bioinformatics/folklore-mcp/folklore-clinical-variant-interpretation/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

Your own site · 80×15

<a href="https://agentmods.dev/skills/helena-bioinformatics/folklore-mcp/folklore-clinical-variant-interpretation"><img src="https://agentmods.dev/badge/skills/helena-bioinformatics/folklore-mcp/folklore-clinical-variant-interpretation.svg" alt="Reviewed on agentmods" width="80" height="20"></a>

Per session 82 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.

When invoked 766 The whole file, excluding the scripts and references it only reads on demand.

Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.

Origin original No closer match found in the catalogue.

Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

Model	Per session	Once invoked
Fable 5.1	$0.00082	$0.00766
Opus 5.5	$0.00033	$0.00306
Sonnet 5.5	$0.00016	$0.00153
Haiku 4.5	$0.00008	$0.00077

Measured 6d ago against content hash e52f782ca366, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

folklore-clinical-variant-interpretation scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 6d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/folklore-clinical-variant-interpretation/SKILL.md · 66 lines

How it starts

The opening of the file, as written. The whole thing — 66 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Folklore variant classification and assessment

Use the hosted MCP at https://api.helena.bio/folklore/v1/mcp. Access is anonymous. Scientific operations run on the Folklore authorities.

Choose the operation

classify_germline_variant: resolve, classify and assess one public GRCh38 nuclear germline SNV or simple indel smaller than 50 bp.
search_variant_literature: retrieve publications linked to one resolved variant.
get_publication_details: read a PMID record and abstract.
search_literature_corpus: retrieve publications for a scientific question, retaining known PMID, DOI or PMCID anchors.
get_gene_disease_associations: read ClinGen assertions for an exact gene symbol or HGNC identifier.
search_disease_genes: find ClinGen assertions by disease name or exact MONDO identifier.
resolve_gene: select a public HGNC identity from a symbol, alias or stable identifier.
get_gene_profile, get_gene_section, search_gene_literature: use the selected gene and returned snapshot, preserving section/cursor bindings.
support_helena: retrieve support links when requested by the user.

Variant call

{"name":"classify_germline_variant","arguments":{"assembly":"GRCh38","query":"NM_007294.4:c.68_69del"}}

The arguments contain assembly and one public variant expression. Preserve transcript versions, reference alleles and any complete report-row assertions.

Read transport, JSON-RPC, MCP and adapter errors first. Then branch on the structured result status:

Status	Action
`resolved`	Verify identity and interpretation status. On success, report automated class, reported criteria, annotation, evidence and provenance. On unavailable, report the typed interpretation error.
`ambiguous`	Present the returned candidates for an explicit selection.
`not_found`	Report the supported-public-variant miss.
`invalid_request`	Request a corrected supported expression.
`unsupported`	State the supported assembly and variant types.
`resolution_unavailable`	Inspect the temporary error and retry policy.

Read the full file on GitHub · 66 lines

Files

What ships with it

3 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

6d ago Changed · -14 lines · -35 tokens per session e52f782ca366
1mo ago Changed · +34 lines · -2 tokens per session 1f9d608dbfb7
2mo ago First seen · 46 lines · 119 tokens per session scan A e10ed73a4f96

Subscribe to this mod's changes

folklore-clinical-variant-interpretation is a skill published in the GitHub repository helena-bioinformatics/folklore-mcp (1 stars, last pushed today), licensed Apache-2.0. It adds 82 tokens to every session and 766 once invoked, about $0.0003 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-31.

Scientific

folklore-clinical-variant-interpretation next to 6 skills from other repositories
Mod	Type	Stars	Last push	Licence	Scan	Tokens	Works with
folklore-clinical-variant-interpretationhelena-bioinformatics/folklore-mcp	Skill	1	today	Apache-2.0	A	82	Codex
instrument-data-to-allotropeanthropics/knowledge-work-plugins	Skill	35k	today	Apache-2.0	A	123	Claude Code
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matlabK-Dense-AI/scientific-agent-skills	Skill	56k	5d ago	MIT	A	44	Claude Code
phylogeneticsK-Dense-AI/scientific-agent-skills	Skill	56k	5d ago	MIT	A	71	Claude Code, Codex
research-engineerdavila7/claude-code-templates	Skill	33k	today	MIT	A	43	Claude Code, Codex
mapping-to-snomedmaziyarpanahi/openmed	Skill	5.8k	today	Apache-2.0	A	205	Claude Code