edgeR

edgeR is a skill for Claude Code, Codex from LeoLin990405/r-analytics-skill. It costs 23 tokens per session (442 once invoked), scanned A, original, MIT.

An R toolkit for finding genes whose activity differs between RNA-sequencing groups, such as treated and untreated samples. It uses statistical models suited to count data.

In plain words
What is it for?
Use it to filter and normalize gene-count data, test two-group or multi-group comparisons, and produce ranked gene results with false-discovery rates and diagnostic plots.
Why use it?
It provides a standard way to account for differences in sequencing depth and natural variation when comparing groups.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add skills/leolin990405/r-analytics-skill/edger
Any agent
npx skills add LeoLin990405/r-analytics-skill --skill edger
Clone the repo
git clone --depth 1 https://github.com/LeoLin990405/r-analytics-skill

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for edgeR

README.md
[![agentmods](https://agentmods.dev/badge/skills/leolin990405/r-analytics-skill/edger.svg)](https://agentmods.dev/skills/leolin990405/r-analytics-skill/edger)
Your own site
<a href="https://agentmods.dev/skills/leolin990405/r-analytics-skill/edger"><img src="https://agentmods.dev/badge/skills/leolin990405/r-analytics-skill/edger.svg" alt="Measured on agentmods" height="20"></a>
Per session 23 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 442 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. Scan, not verified.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00023 $0.00442
Opus 5 $0.00012 $0.00221
Sonnet 5 $0.00005 $0.00088
Haiku 4.5 $0.00002 $0.00044

Measured 5d ago against content hash 8c84707a3dc9, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-06, from the pricing page.

Security

Grade A, and why

edgeR scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 5d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

sub-skills/r-bio/r-bio-rnaseq/edgeR/SKILL.md · 94 lines

What it actually says

edgeR Package

Differential expression analysis for RNA-seq.

Basic Workflow

library(edgeR)

# Create DGEList
dge <- DGEList(counts = count_matrix, group = group)

# Filter low counts
keep <- filterByExpr(dge)
dge <- dge[keep, , keep.lib.sizes = FALSE]

# Normalize
dge <- calcNormFactors(dge)

# Estimate dispersion
dge <- estimateDisp(dge)

# Exact test (two groups)
et <- exactTest(dge)
topTags(et)

GLM Approach

# Design matrix
design <- model.matrix(~0 + group)
colnames(design) <- levels(group)

# Estimate dispersion
dge <- estimateDisp(dge, design)

# Fit GLM
fit <- glmQLFit(dge, design)

# Contrast
contrast <- makeContrasts(TreatmentA - Control, levels = design)
qlf <- glmQLFTest(fit, contrast = contrast)
topTags(qlf)

Results

# Top genes
results <- topTags(qlf, n = Inf)$table

# Significant genes
sig <- results[results$FDR < 0.05, ]

# Volcano plot
plotMD(qlf)

# MA plot
plotSmear(qlf)

Normalization

# TMM (default)
dge <- calcNormFactors(dge, method = "TMM")

# Other methods
dge <- calcNormFactors(dge, method = "RLE")
dge <- calcNormFactors(dge, method = "upperquartile")

# Get normalized counts
cpm(dge)
rpkm(dge, gene.length = gene_lengths)

MDS Plot

plotMDS(dge, col = as.numeric(group))

Export

write.csv(topTags(qlf, n = Inf)$table, "de_results.csv")
Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 5d ago First seen · 94 lines · 23 tokens per session scan A 8c84707a3dc9

Subscribe to this mod's changes

edgeR is a skill published in the GitHub repository LeoLin990405/r-analytics-skill (5 stars, last pushed 5mo ago), licensed MIT. It adds 23 tokens to every session and 442 once invoked, about $0.0001 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-31.

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