r-bio-rnaseq

r-bio-rnaseq is a skill for Claude Code, Codex from LeoLin990405/r-analytics-skill. It costs 29 tokens per session (486 once invoked), scanned A, original, MIT.

An R-based workflow for RNA sequencing analysis, which measures gene activity, using DESeq2 or edgeR to compare conditions and clusterProfiler for gene-set enrichment.

In plain words
What is it for?
Finding genes with different activity between groups, identifying increased or decreased genes, and producing results such as MA plots, PCA plots, and gene-set enrichment analysis.
Why use it?
It provides example steps for filtering, normalising, testing, and reviewing count data instead of assembling the analysis from scratch. RNA sequencing data often needs these steps before meaningful gene comparisons.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Finding genes with different activity between groups, identifying increased or decreased genes, and producing results such as MA plots, PCA plots, and gene-set enrichment analysis.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/leolin990405/r-analytics-skill/r-bio-rnaseq
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add LeoLin990405/r-analytics-skill --skill r-bio-rnaseq
Clone the repo
git clone --depth 1 https://github.com/LeoLin990405/r-analytics-skill

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for r-bio-rnaseq

README.md
[![agentmods](https://agentmods.dev/badge/skills/leolin990405/r-analytics-skill/r-bio-rnaseq/github.svg)](https://agentmods.dev/skills/leolin990405/r-analytics-skill/r-bio-rnaseq)
Your own site
<a href="https://agentmods.dev/skills/leolin990405/r-analytics-skill/r-bio-rnaseq"><img src="https://agentmods.dev/badge/skills/leolin990405/r-analytics-skill/r-bio-rnaseq/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for r-bio-rnaseq

Your own site · 80×15
<a href="https://agentmods.dev/skills/leolin990405/r-analytics-skill/r-bio-rnaseq"><img src="https://agentmods.dev/badge/skills/leolin990405/r-analytics-skill/r-bio-rnaseq.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 29 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 486 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00029 $0.00486
Opus 5 $0.00015 $0.00243
Sonnet 5 $0.00006 $0.00097
Haiku 4.5 $0.00003 $0.00049

Measured 11d ago against content hash 66b06d6768ad, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-11, from the pricing page.

Security

Grade A, and why

r-bio-rnaseq scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 11d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

sub-skills/r-bio/r-bio-rnaseq/SKILL.md · 88 lines

What it actually says

R RNA-seq Analysis

Differential expression analysis.

DESeq2

library(DESeq2)

# Create object
dds <- DESeqDataSetFromMatrix(
  countData = counts,
  colData = sample_info,
  design = ~ condition
)

# Filter low counts
keep <- rowSums(counts(dds)) >= 10
dds <- dds[keep,]

# Run DESeq
dds <- DESeq(dds)

# Results
res <- results(dds, contrast = c("condition", "treated", "control"))
res <- results(dds, alpha = 0.05)
summary(res)

# Significant genes
sig <- res[which(res$padj < 0.05), ]
sig_up <- sig[sig$log2FoldChange > 1, ]
sig_down <- sig[sig$log2FoldChange < -1, ]

# Visualization
plotMA(res)
plotPCA(vst(dds), intgroup = "condition")

edgeR

library(edgeR)

# Create object
y <- DGEList(counts = counts, group = group)

# Filter
keep <- filterByExpr(y)
y <- y[keep, , keep.lib.sizes = FALSE]

# Normalize
y <- calcNormFactors(y)

# Dispersion
y <- estimateDisp(y)

# Test
et <- exactTest(y)
topTags(et)

# GLM approach
design <- model.matrix(~ group)
fit <- glmQLFit(y, design)
qlf <- glmQLFTest(fit, coef = 2)
topTags(qlf)

Gene Set Enrichment

library(clusterProfiler)

# GO enrichment
ego <- enrichGO(gene = sig_genes, OrgDb = org.Hs.eg.db, keyType = "ENSEMBL", ont = "BP")
dotplot(ego)

# KEGG
ekegg <- enrichKEGG(gene = entrez_ids, organism = "hsa")

# GSEA
gse <- gseGO(geneList = ranked_genes, OrgDb = org.Hs.eg.db, ont = "BP")
Files

What ships with it

3 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 11d ago First seen · 88 lines · 29 tokens per session scan A 66b06d6768ad

Subscribe to this mod's changes

r-bio-rnaseq is a skill published in the GitHub repository LeoLin990405/r-analytics-skill (5 stars, last pushed 5mo ago), licensed MIT. It adds 29 tokens to every session and 486 once invoked, about $0.0001 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-31.

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