molfeat

molfeat is a skill for Claude Code from magic3007/dotfiles. It costs 47 tokens per session (4,081 once invoked), scanned B, a copy of molfeat, MIT.

A Python toolkit that converts chemical structures into numerical features for machine-learning models. These features can describe a molecule's structure or come from pretrained models.

In plain words
What is it for?
Turn SMILES strings or molecular objects into fingerprints, descriptors, or embeddings for QSAR models, virtual screening, similarity search, and deep learning.
Why use it?
It avoids building separate chemistry-to-data conversions for common molecular prediction and search tasks.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Good fit Turn SMILES strings or molecular objects into fingerprints, descriptors, or embeddings for QSAR models, virtual screening, similarity search, and deep learning.

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Install with agentmods
npx agentmods add skills/magic3007/dotfiles/molfeat
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add magic3007/dotfiles --skill molfeat
Clone the repo
git clone --depth 1 https://github.com/magic3007/dotfiles

Made for: Claude Code.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for molfeat

README.md
[![agentmods](https://agentmods.dev/badge/skills/magic3007/dotfiles/molfeat.svg)](https://agentmods.dev/skills/magic3007/dotfiles/molfeat)
Your own site
<a href="https://agentmods.dev/skills/magic3007/dotfiles/molfeat"><img src="https://agentmods.dev/badge/skills/magic3007/dotfiles/molfeat.svg" alt="Measured on agentmods" height="20"></a>
Per session 47 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 4,081 The whole file, excluding the scripts and references it only reads on demand.
Security scan B 1 finding. A grade says what 26 rules found in the file — not that it is safe.
Origin 100% copy Near-identical to another mod in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00047 $0.04081
Opus 5 $0.00023 $0.02041
Sonnet 5 $0.00009 $0.00816
Haiku 4.5 $0.00005 $0.00408

Measured 4d ago against content hash 84eead13d12b, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-07, from the pricing page.

Security

Grade B, and why

molfeat scanned grade B with 1 finding against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 4d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Unrestricted tool accessmediumExcessive agency

A wildcard tool grant or "run any command" leaves no least-privilege boundary at all.

Prefer molfeat's built-in pretrained-model cache when possible. For custom embedding caches, use NumPy arrays instead of pickle (pickle can execute arbitrary code when loading untrusted files):
Origin

This is a copy

100% identical to molfeat — 4 lines differ, which has more behind it and is treated as the original. This page carries a canonical link to it rather than competing with it.

claude/skills/scientific-agent-skills/skills/molfeat/SKILL.md · 524 lines

How it starts

The opening of the file, as written. The whole thing — 524 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Molfeat - Molecular Featurization Hub

Overview

Molfeat is a comprehensive Python library for molecular featurization that unifies 100+ pre-trained embeddings and hand-crafted featurizers. Convert chemical structures (SMILES strings or RDKit molecules) into numerical representations for machine learning tasks including QSAR modeling, virtual screening, similarity searching, and deep learning applications. Features fast parallel processing, scikit-learn compatible transformers, and built-in caching.

Version note: Examples target molfeat 0.11.0 (PyPI stable, May 2025). Requires Python 3.9–3.10 (requires-python caps below 3.11). Depends on datamol ≥0.8.0 and PyTorch ≥1.13. Since 0.8.7, prefer datamol Mol objects over raw rdkit.Chem.Mol. Since 0.10.1, fingerprint calculators use RDKit's rdFingerprintGenerator API internally. Since 0.11.0, pretrained models load in memory and base models are set to PyTorch evaluation mode automatically.

When to Use This Skill

This skill should be used when working with:

  • Molecular machine learning: Building QSAR/QSPR models, property prediction
  • Virtual screening: Ranking compound libraries for biological activity
  • Similarity searching: Finding structurally similar molecules
  • Chemical space analysis: Clustering, visualization, dimensionality reduction
  • Deep learning: Training neural networks on molecular data
  • Featurization pipelines: Converting SMILES to ML-ready representations
  • Cheminformatics: Any task requiring molecular feature extraction

Installation

Use a Python 3.9 or 3.10 environment (molfeat does not install on 3.11+ as of 0.11.0):

uv pip install "molfeat==0.11.0"

# With all pip-installable optional dependencies
uv pip install "molfeat[all]==0.11.0"

Optional dependency extras (PyPI):

  • molfeat[dgl] — GNN models (GIN variants); upstream recommends dgl<=2.0 (graphbolt issues in newer DGL)
  • molfeat[graphormer] — Graphormer models
  • molfeat[transformer] — ChemBERTa, ChemGPT, MolT5
  • molfeat[fcd] — FCD descriptors
  • molfeat[pyg] — PyTorch Geometric featurizers
  • molfeat[viz] — NGLView visualization widgets

Read the full file on GitHub · 524 lines

Files

What ships with it

3 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 4d ago First seen · 524 lines · 47 tokens per session scan B 84eead13d12b

Subscribe to this mod's changes

molfeat is a skill published in the GitHub repository magic3007/dotfiles (11 stars, last pushed today), licensed MIT. It adds 47 tokens to every session and 4,081 once invoked, about $0.0002 per session on Opus 5. A static security scan graded it B with 1 finding (unrestricted tool access). It is 100% identical to molfeat, differing in 4 lines, and is treated as a copy.

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