protein-binder-design

protein-binder-design is a skill for Claude Code from NVIDIA-BioNeMo/bionemo-agent-toolkit. It costs 85 tokens per session (1,494 once invoked), scanned A, original, no licence file.

A workflow for designing new protein binders against a chosen protein target using computational models. It coordinates RFdiffusion, ProteinMPNN, and Boltz2 or OpenFold3, including hotspot targeting and in-silico checks.

In plain words
What is it for?
Use it to design minibinders or other de novo binders, target specific epitopes or hotspots, validate candidates computationally, and rank the designs.
Why use it?
It organizes the many steps needed to generate, validate, and rank candidate binders in one campaign.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Part of the bionemo-agent-toolkit plugin — 2 skills shipped together

Good fit Use it to design minibinders or other de novo binders, target specific epitopes or hotspots, validate candidates computationally, and rank the designs.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/nvidia-bionemo/bionemo-agent-toolkit/protein-binder-design
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add NVIDIA-BioNeMo/bionemo-agent-toolkit --skill protein-binder-design
Clone the repo
git clone --depth 1 https://github.com/NVIDIA-BioNeMo/bionemo-agent-toolkit

Made for: Claude Code.

Or install bionemo-agent-toolkit, the plugin that ships this one along with the rest of its 2 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for protein-binder-design

README.md
[![agentmods](https://agentmods.dev/badge/skills/nvidia-bionemo/bionemo-agent-toolkit/protein-binder-design/github.svg)](https://agentmods.dev/skills/nvidia-bionemo/bionemo-agent-toolkit/protein-binder-design)
Your own site
<a href="https://agentmods.dev/skills/nvidia-bionemo/bionemo-agent-toolkit/protein-binder-design"><img src="https://agentmods.dev/badge/skills/nvidia-bionemo/bionemo-agent-toolkit/protein-binder-design/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for protein-binder-design

Your own site · 80×15
<a href="https://agentmods.dev/skills/nvidia-bionemo/bionemo-agent-toolkit/protein-binder-design"><img src="https://agentmods.dev/badge/skills/nvidia-bionemo/bionemo-agent-toolkit/protein-binder-design.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 85 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,494 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 1 finding. A grade says what 26 rules found in the file — not that it is safe.
Origin unknown No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00085 $0.01494
Opus 5 $0.00043 $0.00747
Sonnet 5 $0.00017 $0.00299
Haiku 4.5 $0.00009 $0.00149

Measured 9d ago against content hash a9bfe2b3a477, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-09, from the pricing page.

Security

Grade A, and why

protein-binder-design scanned grade A with 1 finding against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

The scan reads SKILL.md. This mod also ships 5 executable files (scripts/controls.py, scripts/manifest.py, scripts/metrics.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Makes network callslowCapability

Not a fault in itself. Listed so you know the mod talks to something, and to what.

Per-NIM paths, request/response schemas, and worked `curl`/Python examples live in
skills/bionemo-agent-toolkit/skills/protein-binder-design/SKILL.md · 117 lines

The source is not reproduced here

A licence we could not identify

The repository carries a LICENSE file, but it is custom or dual enough that GitHub cannot name it and neither can this catalogue. Unknown terms are not permission, so the body is not copied here. Read the licence at the source and decide for yourself.

Read it on GitHub

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 117 lines · 85 tokens per session scan A a9bfe2b3a477

Subscribe to this mod's changes

protein-binder-design is a skill published in the GitHub repository NVIDIA-BioNeMo/bionemo-agent-toolkit (447 stars, last pushed 4d ago), with no licence file. It adds 85 tokens to every session and 1,494 once invoked, about $0.0004 per session on Opus 5. A static security scan graded it A with 1 finding (makes network calls). No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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