bio-geo-data

bio-geo-data is a skill for Claude Code, Codex from thesecondfox/skill. It costs 53 tokens per session (2,980 once invoked), scanned A, original, MIT.

A tool for searching NCBI's Gene Expression Omnibus (GEO), a public collection of gene-activity experiments. It uses Biopython to find microarray and RNA-sequencing datasets and connect them to sequencing runs in SRA.

In plain words
What is it for?
Use it to find datasets by organism, tissue, or condition, download expression matrices, and link GEO series to SRA runs.
Why use it?
It removes the need to search GEO manually and helps connect experiment records with downloadable expression data and sequencing files.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to find datasets by organism, tissue, or condition, download expression matrices, and link GEO series to SRA runs.

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Install with agentmods
npx agentmods add skills/thesecondfox/skill/bio-database-access-geo-data
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add thesecondfox/skill --skill bio-database-access-geo-data
Clone the repo
git clone --depth 1 https://github.com/thesecondfox/skill

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for bio-geo-data

README.md
[![agentmods](https://agentmods.dev/badge/skills/thesecondfox/skill/bio-database-access-geo-data/github.svg)](https://agentmods.dev/skills/thesecondfox/skill/bio-database-access-geo-data)
Your own site
<a href="https://agentmods.dev/skills/thesecondfox/skill/bio-database-access-geo-data"><img src="https://agentmods.dev/badge/skills/thesecondfox/skill/bio-database-access-geo-data/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for bio-geo-data

Your own site · 80×15
<a href="https://agentmods.dev/skills/thesecondfox/skill/bio-database-access-geo-data"><img src="https://agentmods.dev/badge/skills/thesecondfox/skill/bio-database-access-geo-data.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 53 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,980 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 1 finding. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00053 $0.02980
Opus 5.5 $0.00021 $0.01192
Sonnet 5.5 $0.00011 $0.00596
Haiku 4.5 $0.00005 $0.00298

Measured 1mo ago against content hash ab169f6f18f2, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

bio-geo-data scanned grade A with 1 finding against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 1mo ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Makes network callslowCapability

Not a fault in itself. Listed so you know the mod talks to something, and to what.

wget -r -np -nd ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE123nnn/GSE123456/
Common_Skills/bio-database-access-geo-data/SKILL.md · 384 lines

How it starts

The opening of the file, as written. The whole thing — 384 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Version Compatibility

Reference examples tested with: BioPython 1.83+, Entrez Direct 21.0+

Before using code patterns, verify installed versions match. If versions differ:

  • Python: pip show <package> then help(module.function) to check signatures
  • CLI: <tool> --version then <tool> --help to confirm flags

If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying.

GEO Data

Query and access Gene Expression Omnibus datasets using Biopython's Entrez module.

"Find expression datasets in GEO" → Search GEO for microarray/RNA-seq datasets by organism, tissue, or condition, then download expression matrices or link to SRA runs.

  • Python: Entrez.esearch(db='gds', term=...) (BioPython)
  • CLI: esearch -db gds -query "term" (Entrez Direct)

Required Setup

from Bio import Entrez

Entrez.email = '[email protected]'  # Required by NCBI
Entrez.api_key = 'your_api_key'          # Optional

GEO Database Types

Database db value Description
GEO DataSets gds Curated datasets (GDS*)
GEO Profiles geoprofiles Individual gene profiles

GEO Record Types:

Prefix Type Description
GSE Series Complete study/experiment
GSM Sample Individual sample
GPL Platform Array/sequencing platform
GDS DataSet Curated, normalized dataset

Searching GEO

Search GEO DataSets (GDS)

from Bio import Entrez

Entrez.email = '[email protected]'

# Search curated datasets
handle = Entrez.esearch(db='gds', term='breast cancer AND Homo sapiens[orgn]', retmax=10)
record = Entrez.read(handle)
handle.close()

print(f"Found {record['Count']} datasets")
print(f"IDs: {record['IdList']}")

Search GEO Series (GSE)

# Search GEO Series via gds database
# Use entry_type filter
handle = Entrez.esearch(db='gds', term='RNA-seq[title] AND human[orgn] AND gse[entry_type]', retmax=10)
record = Entrez.read(handle)
handle.close()

Read the full file on GitHub · 384 lines

Files

What ships with it

1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 1mo ago First seen · 384 lines · 53 tokens per session scan A ab169f6f18f2

Subscribe to this mod's changes

bio-geo-data is a skill published in the GitHub repository thesecondfox/skill (3 stars, last pushed 6mo ago), licensed MIT. It adds 53 tokens to every session and 2,980 once invoked, about $0.0002 per session on Opus 5.5. A static security scan graded it A with 1 finding (makes network calls). No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-31.

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