Getting it into your agent
One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.
npx skills add wentorai/research-plugins --skill retrosynthesis-guidegit clone --depth 1 https://github.com/wentorai/research-pluginsWrote this? Show the measurements
A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.
[](https://agentmods.dev/skills/wentorai/research-plugins/retrosynthesis-guide)<a href="https://agentmods.dev/skills/wentorai/research-plugins/retrosynthesis-guide"><img src="https://agentmods.dev/badge/skills/wentorai/research-plugins/retrosynthesis-guide/github.svg" alt="Measured on agentmods" height="20"></a>Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.
<a href="https://agentmods.dev/skills/wentorai/research-plugins/retrosynthesis-guide"><img src="https://agentmods.dev/badge/skills/wentorai/research-plugins/retrosynthesis-guide.svg" alt="Reviewed on agentmods" width="80" height="20"></a>What it costs to keep this loaded
Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.
| Model | Per session | Once invoked |
|---|---|---|
| Fable 5.1 | $0.00013 | $0.02006 |
| Opus 5 | $0.00006 | $0.01003 |
| Sonnet 5 | $0.00003 | $0.00401 |
| Haiku 4.5 | $0.00001 | $0.00201 |
Grade B, and why
retrosynthesis-guide scanned grade B with 2 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 6d ago.
A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.
Sends data to an external URLmediumData exfiltration
A POST to an outside endpoint may be telemetry or may be exfiltration; either way the mod talks to somewhere, and you should know where.
response = requests.post( "https://askcos.mit.edu/api/retro/", Makes network callslowCapability
Not a fault in itself. Listed so you know the mod talks to something, and to what.
response = requests.post( How it starts
The opening of the file, as written. The whole thing — 216 lines — stays where its author put it; the contents beside it link to each section on GitHub.
Retrosynthesis Guide
Plan synthetic routes for target molecules using retrosynthetic analysis principles and computational tools, from Corey's logic to modern AI-driven approaches.
What Is Retrosynthesis?
Retrosynthesis works backward from a target molecule to identify simpler, commercially available precursors:
Target Molecule (TM)
|
[Disconnection 1] ← Apply transform (reverse of a known reaction)
|
Synthon A + Synthon B
| |
[Available] [Disconnection 2]
|
Synthon C + Synthon D
| |
[Available] [Available]
Key terminology:
- Target Molecule (TM): The molecule you want to synthesize
- Synthon: Idealized reactive fragment from a disconnection
- Synthetic Equivalent: Real reagent corresponding to a synthon
- Transform: Reverse of a chemical reaction (retro-reaction)
- FGI (Functional Group Interconversion): Convert one functional group to another to enable a disconnection
Corey's Retrosynthetic Strategies
Strategic Bond Disconnections
| Strategy | Description | When to Use |
|---|---|---|
| FGI | Convert functional groups to enable disconnections | When direct disconnection is not possible |
| C-C Bond disconnection | Break carbon-carbon bonds | Building the carbon skeleton |
| C-X Bond disconnection | Break carbon-heteroatom bonds | Functional group installation |
| Ring disconnection | Open rings to identify acyclic precursors | Cyclic target molecules |
| Symmetry exploitation | Use molecular symmetry to simplify analysis | Symmetric molecules |
| Convergent synthesis | Combine two complex fragments late | Minimize linear step count |
Common Disconnection Patterns
# Alcohol (C-OH) → Carbonyl reduction
R-CH(OH)-R' ⟹ R-CO-R' + NaBH4/LiAlH4
# Amine (C-N) → Reductive amination
R-CH2-NH-R' ⟹ R-CHO + R'-NH2
# C-C Bond (aldol) → Aldol retro
R-CH(OH)-CH2-CO-R' ⟹ R-CHO + CH3-CO-R'
# C-C Bond (Grignard) → Grignard retro
R-CH(OH)-R' ⟹ R-CHO + R'-MgBr
# Ester (C-O) → Fischer esterification retro
R-COO-R' ⟹ R-COOH + R'-OH
# Amide (C-N) → Amide coupling retro
R-CO-NH-R' ⟹ R-COOH + R'-NH2
# Diels-Alder → Retro Diels-Alder
Cyclohexene derivative ⟹ Diene + Dienophile
# Wittig → Retro Wittig
R-CH=CH-R' ⟹ R-CHO + R'-CH2-PPh3
What this file has done since we first saw it
Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.
- 6d ago First seen · 216 lines · 13 tokens per session scan B 6674c892f97b
retrosynthesis-guide is a skill published in the GitHub repository wentorai/research-plugins (291 stars, last pushed 2mo ago), licensed MIT. It adds 13 tokens to every session and 2,006 once invoked, about $0.0001 per session on Opus 5. A static security scan graded it B with 2 findings (sends data to an external url, makes network calls). No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.
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