cosmic-database

cosmic-database is a skill for Claude Code, Codex from Zaoqu-Liu/ScienceClaw. It costs 39 tokens per session (2,565 once invoked), scanned A, a copy of cosmic-database, MIT.

A workflow for accessing COSMIC, a cancer research database of mutations and other genomic changes found in tumors. It requires authentication and may require a commercial license.

In plain words
What is it for?
Querying somatic mutations, cancer-related genes, mutational signatures, gene fusions, structural variants, copy-number changes, and drug-resistance mutations.
Why use it?
It brings cancer mutation data into research and analysis workflows without requiring each task to gather the data manually.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Needs its repository: it runs a file that does not travel with it, so clone the repository first. The line is python scripts/download_cosmic.py [email protected] --data-type mutations.

Good fit Querying somatic mutations, cancer-related genes, mutational signatures, gene fusions, structural variants, copy-number changes, and drug-resistance mutations.

Compare 6 skills from other repositories ↓
Install

Getting it into your agent

It runs from inside its repository, so the clone comes first — what it calls does not travel with the file alone.

Clone the repo
git clone --depth 1 https://github.com/Zaoqu-Liu/ScienceClaw
agentmods
npx agentmods add skills/zaoqu-liu/scienceclaw/cosmic-database

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for cosmic-database

README.md
[![agentmods](https://agentmods.dev/badge/skills/zaoqu-liu/scienceclaw/cosmic-database/github.svg)](https://agentmods.dev/skills/zaoqu-liu/scienceclaw/cosmic-database)
Your own site
<a href="https://agentmods.dev/skills/zaoqu-liu/scienceclaw/cosmic-database"><img src="https://agentmods.dev/badge/skills/zaoqu-liu/scienceclaw/cosmic-database/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for cosmic-database

Your own site · 80×15
<a href="https://agentmods.dev/skills/zaoqu-liu/scienceclaw/cosmic-database"><img src="https://agentmods.dev/badge/skills/zaoqu-liu/scienceclaw/cosmic-database.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 39 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,565 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin 86% copy Near-identical to another mod in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00039 $0.02565
Opus 5.5 $0.00016 $0.01026
Sonnet 5.5 $0.00008 $0.00513
Haiku 4.5 $0.00004 $0.00257

Measured 1mo ago against content hash dde1be118e32, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

cosmic-database scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 1mo ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

This is a copy

86% identical to cosmic-database — 10 lines differ, which has more behind it and is treated as the original. This page carries a canonical link to it rather than competing with it.

skills/cosmic-database/SKILL.md · 336 lines

How it starts

The opening of the file, as written. The whole thing — 336 lines — stays where its author put it; the contents beside it link to each section on GitHub.

COSMIC Database

Overview

COSMIC (Catalogue of Somatic Mutations in Cancer) is the world's largest and most comprehensive database for exploring somatic mutations in human cancer. Access COSMIC's extensive collection of cancer genomics data, including millions of mutations across thousands of cancer types, curated gene lists, mutational signatures, and clinical annotations programmatically.

When to Use This Skill

This skill should be used when:

  • Downloading cancer mutation data from COSMIC
  • Accessing the Cancer Gene Census for curated cancer gene lists
  • Retrieving mutational signature profiles
  • Querying structural variants, copy number alterations, or gene fusions
  • Analyzing drug resistance mutations
  • Working with cancer cell line genomics data
  • Integrating cancer mutation data into bioinformatics pipelines
  • Researching specific genes or mutations in cancer contexts

Prerequisites

Account Registration

COSMIC requires authentication for data downloads:

Python Requirements

uv pip install requests pandas

Quick Start

1. Basic File Download

Use the scripts/download_cosmic.py script to download COSMIC data files:

from scripts.download_cosmic import download_cosmic_file

# Download mutation data
download_cosmic_file(
    email="[email protected]",
    password="your_password",
    filepath="GRCh38/cosmic/latest/CosmicMutantExport.tsv.gz",
    output_filename="cosmic_mutations.tsv.gz"
)

2. Command-Line Usage

# Download using shorthand data type
python scripts/download_cosmic.py [email protected] --data-type mutations

# Download specific file
python scripts/download_cosmic.py [email protected] \
    --filepath GRCh38/cosmic/latest/cancer_gene_census.csv

# Download for specific genome assembly
python scripts/download_cosmic.py [email protected] \
    --data-type gene_census --assembly GRCh37 -o cancer_genes.csv

Read the full file on GitHub · 336 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 1mo ago First seen · 336 lines · 39 tokens per session scan A dde1be118e32

Subscribe to this mod's changes

cosmic-database is a skill published in the GitHub repository Zaoqu-Liu/ScienceClaw (60 stars, last pushed 7mo ago), licensed MIT. It adds 39 tokens to every session and 2,565 once invoked, about $0.0002 per session on Opus 5.5. A static security scan graded it A with 0 findings. It is 86% identical to cosmic-database, differing in 10 lines, and is treated as a copy.

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