pathml

pathml is a skill for Claude Code, Codex from AndyZhuang/Opentest. It costs 69 tokens per session (1,664 once invoked), scanned A, a copy of pathml, MIT.

A Python toolkit for analyzing whole-slide pathology images, the very large digital scans used by pathologists to examine tissue.

In plain words
What is it for?
Use it to load and process slide files, normalize stains, detect and classify nuclei, build spatial cell or tissue graphs, analyze multiplexed images, and train machine-learning models.
Why use it?
It provides reusable steps for preparing these images and studying cells, tissue structure, and multiple biological markers.

Skill for Claude CodeCodex

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add skills/andyzhuang/opentest/pathml
Any agent
npx skills add AndyZhuang/Opentest --skill pathml
Clone the repo
git clone --depth 1 https://github.com/AndyZhuang/Opentest

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for pathml

README.md
[![agentmods](https://agentmods.dev/badge/skills/andyzhuang/opentest/pathml.svg)](https://agentmods.dev/skills/andyzhuang/opentest/pathml)
Your own site
<a href="https://agentmods.dev/skills/andyzhuang/opentest/pathml"><img src="https://agentmods.dev/badge/skills/andyzhuang/opentest/pathml.svg" alt="Measured on agentmods" height="20"></a>
Per session 69 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,664 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. Scan, not verified.
Origin 88% copy Near-identical to another mod in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5 $0.00069 $0.01664
Opus 5 $0.00034 $0.00832
Sonnet 5 $0.00014 $0.00333
Haiku 4.5 $0.00007 $0.00166

Measured 5d ago against content hash 0c5768bda03f, method: parsed. Prices are Anthropic first-party input rates as of 2026-08-30, from the pricing page.

Security

Grade A, and why

pathml scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 5d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

This is a copy

88% identical to pathml — 6 lines differ, which has more behind it and is treated as the original. This page carries a canonical link to it rather than competing with it.

skills/labclaw/bio/pathml/SKILL.md · 166 lines

How it starts

The opening of the file, as written. The whole thing — 166 lines — stays where its author put it; the contents beside it link to each section on GitHub.

PathML

Overview

PathML is a comprehensive Python toolkit for computational pathology workflows, designed to facilitate machine learning and image analysis for whole-slide pathology images. The framework provides modular, composable tools for loading diverse slide formats, preprocessing images, constructing spatial graphs, training deep learning models, and analyzing multiparametric imaging data from technologies like CODEX and multiplex immunofluorescence.

When to Use This Skill

Apply this skill for:

  • Loading and processing whole-slide images (WSI) in various proprietary formats
  • Preprocessing H&E stained tissue images with stain normalization
  • Nucleus detection, segmentation, and classification workflows
  • Building cell and tissue graphs for spatial analysis
  • Training or deploying machine learning models (HoVer-Net, HACTNet) on pathology data
  • Analyzing multiparametric imaging (CODEX, Vectra, MERFISH) for spatial proteomics
  • Quantifying marker expression from multiplex immunofluorescence
  • Managing large-scale pathology datasets with HDF5 storage
  • Tile-based analysis and stitching operations

Core Capabilities

PathML provides six major capability areas documented in detail within reference files:

1. Image Loading & Formats

Load whole-slide images from 160+ proprietary formats including Aperio SVS, Hamamatsu NDPI, Leica SCN, Zeiss ZVI, DICOM, and OME-TIFF. PathML automatically handles vendor-specific formats and provides unified interfaces for accessing image pyramids, metadata, and regions of interest.

See: references/image_loading.md for supported formats, loading strategies, and working with different slide types.

2. Preprocessing Pipelines

Build modular preprocessing pipelines by composing transforms for image manipulation, quality control, stain normalization, tissue detection, and mask operations. PathML's Pipeline architecture enables reproducible, scalable preprocessing across large datasets.

Key transforms:

  • StainNormalizationHE - Macenko/Vahadane stain normalization
  • TissueDetectionHE, NucleusDetectionHE - Tissue/nucleus segmentation
  • MedianBlur, GaussianBlur - Noise reduction
  • LabelArtifactTileHE - Quality control for artifacts

Read the full file on GitHub · 166 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 5d ago First seen · 166 lines · 69 tokens per session scan A 0c5768bda03f

Subscribe to this mod's changes

pathml is a skill published in the GitHub repository AndyZhuang/Opentest (22 stars, last pushed 5mo ago), licensed MIT. It adds 69 tokens to every session and 1,664 once invoked, about $0.0003 per session on Opus 5. A static security scan graded it A with 0 findings. It is 88% identical to pathml, differing in 6 lines, and is treated as a copy.

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