OpenST Skills Index

OpenST Skills Index is a skill for Claude Code, Codex from aristoteleo/PantheonOS. It costs 32 tokens per session (288 once invoked), scanned A, original, BSD-2-Clause.

A workflow for Open-ST, a spatial transcriptomics method that measures gene activity across tissue at very small spatial scales. It processes data from raw sequencing files into single-cell data objects that retain tissue locations.

In plain words
What is it for?
Processing Open-ST BCL or FASTQ files, aligning transcripts, matching them to tissue images, segmenting cells, assigning transcripts, reconstructing serial sections in 3D, and exploring the resulting data.
Why use it?
Open-ST analysis involves several dependent steps, from sequencing and alignment to image registration, cell segmentation, and three-dimensional reconstruction. Missing an earlier step can make later results unusable.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Processing Open-ST BCL or FASTQ files, aligning transcripts, matching them to tissue images, segmenting cells, assigning transcripts, reconstructing serial sections in 3D, and exploring the resulting data.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/aristoteleo/pantheonos/openst
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add aristoteleo/PantheonOS --skill openst
Clone the repo
git clone --depth 1 https://github.com/aristoteleo/PantheonOS

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for OpenST Skills Index

README.md
[![agentmods](https://agentmods.dev/badge/skills/aristoteleo/pantheonos/openst/github.svg)](https://agentmods.dev/skills/aristoteleo/pantheonos/openst)
Your own site
<a href="https://agentmods.dev/skills/aristoteleo/pantheonos/openst"><img src="https://agentmods.dev/badge/skills/aristoteleo/pantheonos/openst/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for OpenST Skills Index

Your own site · 80×15
<a href="https://agentmods.dev/skills/aristoteleo/pantheonos/openst"><img src="https://agentmods.dev/badge/skills/aristoteleo/pantheonos/openst.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 32 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 288 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00032 $0.00288
Opus 5 $0.00016 $0.00144
Sonnet 5 $0.00006 $0.00058
Haiku 4.5 $0.00003 $0.00029

Measured 9d ago against content hash 7a8e46cdfe6e, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-09, from the pricing page.

Security

Grade A, and why

OpenST Skills Index scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

pantheon/factory/templates/skills/omics/upstream_processing/openst/SKILL.md · 40 lines

What it actually says

OpenST Skills

Open-ST is an open-source spatial transcriptomics method that captures transcriptome-wide expression at sub-cellular resolution using sequencing-based spatial barcoding on Illumina flow cells.

Available Skills

Computational Analysis Pipeline

Complete end-to-end computational workflow for processing Open-ST data, covering all 6 stages from raw data to analysis-ready objects.

Skill file: openst_computational.md

When to use:

  • Processing raw Open-ST BCL/FASTQ files
  • Running spacemake for transcriptomic alignment
  • Aligning spatial coordinates to tissue images
  • Segmenting cells and assigning transcripts
  • Reconstructing 3D spatial data from serial sections
  • Performing downstream exploratory analysis on Open-ST data

Using Skills

  1. Read the computational pipeline skill for the full step-by-step workflow
  2. Follow stages sequentially: Each stage depends on the previous one
  3. Check system requirements: 128 GB RAM recommended, GPU for segmentation/alignment
Files

What ships with it

1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 40 lines · 32 tokens per session scan A 7a8e46cdfe6e

Subscribe to this mod's changes

OpenST Skills Index is a skill published in the GitHub repository aristoteleo/PantheonOS (484 stars, last pushed today), licensed BSD-2-Clause. It adds 32 tokens to every session and 288 once invoked, about $0.0002 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

Related

Other skills, from other repositories

histolab

Lightweight WSI tile extraction and preprocessing. Use for basic slide processing tissue detection, tile extraction, stain normalization for H&E images. Best for simple pipelines, dataset preparation, quick tile-based analysis. For advanced spatial proteomics, multiplexed imaging, or deep learning pipelines use pathml.

synthetic-sciences/openscience · 62 tokens

torch-geometric

Graph Neural Networks (PyG). Node/graph classification, link prediction, GCN, GAT, GraphSAGE, heterogeneous graphs, molecular property prediction, for geometric deep learning.

synthetic-sciences/openscience · 41 tokens

zarr-python

Chunked N-D arrays for cloud storage. Compressed arrays, parallel I/O, S3/GCS integration, NumPy/Dask/Xarray compatible, for large-scale scientific computing pipelines.

synthetic-sciences/openscience · 42 tokens

glycobiology

Glycosylation site prediction and glycobiology analysis. N-glycosylation motif finding, O-glycosylation hotspot prediction, glycan structure resources. Lightweight, pure Python. For protein function queries use uniprot-database; for structure analysis use alphafold-database.

synthetic-sciences/openscience · 67 tokens

pyhealth

Comprehensive healthcare AI toolkit for developing, testing, and deploying machine learning models with clinical data. This skill should be used when working with electronic health records (EHR), clinical prediction tasks (mortality, readmission, drug recommendation), medical coding systems (ICD, NDC, ATC)…

synthetic-sciences/openscience · 109 tokens

deepchem

Molecular ML with diverse featurizers and pre-built datasets. Use for property prediction (ADMET, toxicity) with traditional ML or GNNs when you want extensive featurization options and MoleculeNet benchmarks. Best for quick experiments with pre-trained models, diverse molecular representations. For graph-first…

synthetic-sciences/openscience · 78 tokens