sdrf-convert

sdrf-convert is a skill for Claude Code from bigbio/sdrf-skills. It costs 36 tokens per session (989 once invoked), scanned A, original, MIT.

A guide for turning SDRF sample descriptions into settings or files for proteomics analysis tools. It covers tools such as OpenMS, MaxQuant, DIA-NN, MSstats, and NormalyzerDE.

In plain words
What is it for?
Use it to compare pipelines, check SDRF compatibility, and decide how to move from sample metadata to analysis.
Why use it?
It helps choose an analysis route that matches the experiment, such as DIA, DDA, targeted, or label-free data.

Skill for Claude Code

Written for Claude Code: user-invocable in frontmatter.

Part of the sdrf-skills plugin — 16 skills, 2 hooks, 1 MCP server shipped together

Good fit Use it to compare pipelines, check SDRF compatibility, and decide how to move from sample metadata to analysis.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/bigbio/sdrf-skills/sdrf-convert
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add bigbio/sdrf-skills --skill sdrf-convert
Clone the repo
git clone --depth 1 https://github.com/bigbio/sdrf-skills

Made for: Claude Code.

Or install sdrf-skills, the plugin that ships this one along with the rest of its 16 skills, 2 hooks, 1 MCP server.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for sdrf-convert

README.md
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Your own site
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Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for sdrf-convert

Your own site · 80×15
<a href="https://agentmods.dev/skills/bigbio/sdrf-skills/sdrf-convert"><img src="https://agentmods.dev/badge/skills/bigbio/sdrf-skills/sdrf-convert.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 36 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 989 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00036 $0.00989
Opus 5 $0.00018 $0.00495
Sonnet 5 $0.00007 $0.00198
Haiku 4.5 $0.00004 $0.00099

Measured 4d ago against content hash 436e101e9300, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-10, from the pricing page.

Security

Grade A, and why

sdrf-convert scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 4d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/sdrf-convert/SKILL.md · 101 lines

How it starts

The opening of the file, as written. The whole thing — 101 lines — stays where its author put it; the contents beside it link to each section on GitHub.

SDRF Pipeline Guidance

You are helping the user choose and configure an analysis pipeline from their SDRF.

Supported Pipelines

sdrf-pipelines can convert SDRF to these formats:

Pipeline Command Best For
OpenMS convert-openms Flexible workflows, custom pipelines
MaxQuant convert-maxquant DDA label-free, TMT, SILAC (desktop)
DIA-NN convert-diann DIA/SWATH, PlexDIA (fast, scalable)
MSstats convert-msstats Statistical analysis (downstream of search)
NormalyzerDE convert-normalyzerde Normalization and differential expression
quantms Nextflow pipeline Cloud/HPC, complete workflow (uses SDRF natively)

Pipeline Recommendation Logic

Is it targeted (PRM/SRM)?   acquisition method = PRIDE:0000629 (PRM) / PRIDE:0000630 (SRM)
├── YES → Skyline / OpenSWATH (targeted) — not the DDA/DIA tree below
│
Is it DIA data?            acquisition method = PRIDE:0000450 (incl. diaPASEF PRIDE:0000650, SWATH PRIDE:0000447)
├── YES → DIA-NN (fastest, best DIA performance)
│         Also consider: quantms with DIA module
│
└── NO (DDA) →
    ├── Label-free?
    │   ├── Small study (<50 samples) → MaxQuant
    │   ├── Large study (>50 samples) → quantms (scalable)
    │   └── Custom workflow needed → OpenMS
    │
    ├── TMT/iTRAQ?
    │   ├── Standard TMT → MaxQuant or quantms
    │   ├── TMT + phospho → MaxQuant (PTM scoring)
    │   └── Large TMT cohort → quantms
    │
    └── SILAC?
        └── MaxQuant (best SILAC support)

For statistical analysis (after search):
  → MSstats (gold standard for proteomics statistics)
  → NormalyzerDE (normalization comparison)

For cloud/HPC processing:
  → quantms (Nextflow, reads SDRF directly, no conversion needed)

Compatibility Checks

Before recommending, verify SDRF compatibility:

  1. Label type: DIA-NN doesn't support TMT (except PlexDIA). MaxQuant supports all.
  2. File format: Check if raw files are compatible with the pipeline
  3. Modification support: Some pipelines have limited PTM support
  4. Column completeness: Each pipeline needs specific SDRF columns

Read the full file on GitHub · 101 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 4d ago Changed 436e101e9300
  2. 10d ago First seen · 101 lines · 36 tokens per session scan A 1976dc98cb75

Subscribe to this mod's changes

sdrf-convert is a skill published in the GitHub repository bigbio/sdrf-skills (18 stars, last pushed 4d ago), licensed MIT. It adds 36 tokens to every session and 989 once invoked, about $0.0002 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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