imaging-genetics-models

imaging-genetics-models is a skill for Claude Code, Codex from CUHK-AIM-Group/NeuroClaw. It costs 114 tokens per session (1,035 once invoked), scanned A, original, MIT.

A toolkit for studying links between genetic variants and brain or medical images. It supports association tests, mixed models that account for related people, polygenic scores, and methods that compare two sets of measurements.

In plain words
What is it for?
Use it to test whether genetic variants relate to imaging traits, calculate subject-level polygenic scores, compare genotype and imaging datasets, and construct audited PLINK2 commands.
Why use it?
It helps avoid building these analyses from scratch and makes important factors such as ancestry, age, sex, study site, and relatedness explicit before interpreting results.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to test whether genetic variants relate to imaging traits, calculate subject-level polygenic scores, compare genotype and imaging datasets, and construct audited PLINK2 commands.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/cuhk-aim-group/neuroclaw/imaging-genetics-models
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add CUHK-AIM-Group/NeuroClaw --skill imaging-genetics-models
Clone the repo
git clone --depth 1 https://github.com/CUHK-AIM-Group/NeuroClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for imaging-genetics-models

README.md
[![agentmods](https://agentmods.dev/badge/skills/cuhk-aim-group/neuroclaw/imaging-genetics-models/github.svg)](https://agentmods.dev/skills/cuhk-aim-group/neuroclaw/imaging-genetics-models)
Your own site
<a href="https://agentmods.dev/skills/cuhk-aim-group/neuroclaw/imaging-genetics-models"><img src="https://agentmods.dev/badge/skills/cuhk-aim-group/neuroclaw/imaging-genetics-models/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for imaging-genetics-models

Your own site · 80×15
<a href="https://agentmods.dev/skills/cuhk-aim-group/neuroclaw/imaging-genetics-models"><img src="https://agentmods.dev/badge/skills/cuhk-aim-group/neuroclaw/imaging-genetics-models.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 114 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,035 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Output Handling · line 41
    Model output is used without validation or sanitization. Unvalidated output injected into downstream contexts (SQL, shell, HTML) enables injection attacks and arbitrary code execution.
    Fix: Validate and sanitize all model output before using it in downstream contexts. Use parameterized queries for SQL, shell quoting for commands, and HTML encoding for web output.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00114 $0.01035
Opus 5 $0.00057 $0.00517
Sonnet 5 $0.00023 $0.00207
Haiku 4.5 $0.00011 $0.00103

Measured 12d ago against content hash e763284fcfff, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

imaging-genetics-models scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 12d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (scripts/train_reference.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/imaging-genetics-models/SKILL.md · 155 lines

How it starts

The opening of the file, as written. The whole thing — 155 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Imaging Genetics Models Skill

Overview

imaging-genetics-models provides matrix-based association, polygenic scoring, and multivariate genotype-imaging analysis. It also builds explicit PLINK2 commands without embedding or redistributing the external executable.

Supported modes

Mode Required arrays Output
association genotype, phenotype covariate-adjusted variant tests
lmm above plus kinship kinship-aware variant tests
prs genotype, weights subject polygenic score
pls X, Y paired latent components
cca X, Y canonical variates

Population structure, ancestry, batch, age, sex, site, and relatedness must be handled before genetic effects are interpreted.


Installation

pip install numpy pandas scipy scikit-learn statsmodels joblib

For genome-wide command-line analyses, install PLINK2 separately and execute the generated command through NeuroClaw's audited shell workflow.


Workflows

1. Variant-imaging association

Create an NPZ bundle:

genotype:   [subjects, variants]
phenotype:  [subjects] or [subjects, phenotypes]
variant_id: [variants] (optional)
covariates: [subjects, covariates] (optional)
kinship:    [subjects, subjects] (required only for `lmm`)
python skills/imaging-genetics-models/scripts/train_reference.py \
  --input imaging_genetics.npz \
  --model association \
  --output-dir run_models_output/imaging_gwas

Use --model lmm when the bundle contains a kinship matrix.

2. Polygenic score

genotype:   [subjects, variants]
weights:    [variants]
subject_id: [subjects] (optional)
python skills/imaging-genetics-models/scripts/train_reference.py \
  --input prs_bundle.npz \
  --model prs \
  --output-dir run_models_output/prs

3. PLS or CCA

X: [subjects, genetic features]
Y: [subjects, imaging phenotypes]
python skills/imaging-genetics-models/scripts/train_reference.py \
  --input imaging_genetics.npz \
  --model cca \
  --components 3 \
  --output-dir run_models_output/cca

Read the full file on GitHub · 155 lines

Files

What ships with it

1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 12d ago First seen · 155 lines · 114 tokens per session scan A e763284fcfff

Subscribe to this mod's changes

imaging-genetics-models is a skill published in the GitHub repository CUHK-AIM-Group/NeuroClaw (85 stars, last pushed 5d ago), licensed MIT. It adds 114 tokens to every session and 1,035 once invoked, about $0.0006 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

Related

Other skills, from other repositories

instrument-data-to-allotrope

Convert laboratory instrument output files (PDF, CSV, Excel, TXT) to Allotrope Simple Model (ASM) JSON format or flattened 2D CSV. Use this skill when scientists need to standardize instrument data for LIMS systems, data lakes, or downstream analysis. Supports auto-detection of instrument types. Outputs include full…

anthropics/knowledge-work-plugins · 123 tokens

matlab

Build, review, migrate, and safely plan MATLAB or GNU Octave numerical workflows, including arrays, tabular/time data, tests, projects, graphics, MAT files, and explicit Python interoperability.

K-Dense-AI/scientific-agent-skills · 42 tokens

exploratory-data-analysis

Perform bounded, local exploratory analysis of explicitly supported scientific files. Use for redacted CSV/TSV/JSON profiles; optional NumPy, HDF5, FASTA/FASTQ, and basic image metadata inspection; missingness/leakage audits; outlier and transformation sensitivity; and rigorous EDA report scaffolds. Other domain…

K-Dense-AI/scientific-agent-skills · 83 tokens

phylogenetics

Build and analyze phylogenetic trees using MAFFT (multiple alignment), IQ-TREE 2 (maximum likelihood), and FastTree (fast NJ/ML). Visualize with ETE3 or FigTree. For evolutionary analysis, microbial genomics, viral phylodynamics, protein family analysis, and molecular clock studies.

K-Dense-AI/scientific-agent-skills · 68 tokens

research-engineer

An uncompromising Academic Research Engineer. Operates with absolute scientific rigor, objective criticism, and zero flair. Focuses on theoretical correctness, formal verification, and optimal implementation across any required technology.

davila7/claude-code-templates · 43 tokens

mapping-to-snomed

Maps clinical concept spans extracted by OpenMed to SNOMED CT concepts through a USER-SUPPLIED terminology server (the user's own Ontoserver, Snowstorm, or UMLS/UTS), never a bundled vocabulary. Use when the user wants to code findings, disorders, procedures, body structures, or substances to SNOMED CT, run an ECL…

maziyarpanahi/openmed · 205 tokens