arboreto

arboreto is a skill for Claude Code, Codex from dralkh/seerai. It costs 66 tokens per session (2,108 once invoked), scanned A, a copy of arboreto, MIT.

A Python library for inferring gene regulatory networks: maps that estimate which transcription factors, proteins that control gene activity, may influence which target genes. It analyzes gene-expression measurements from samples or individual cells.

In plain words
What is it for?
Analyzing bulk or single-cell RNA data with the GRNBoost2 or GENIE3 methods, including runs spread across local computer cores or remote clusters.
Why use it?
Expression tables show patterns but do not directly list regulatory relationships. This helps turn those patterns into a ranked list of possible transcription factor–target connections.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Analyzing bulk or single-cell RNA data with the GRNBoost2 or GENIE3 methods, including runs spread across local computer cores or remote clusters.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/dralkh/seerai/arboreto
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add dralkh/seerai --skill arboreto
Clone the repo
git clone --depth 1 https://github.com/dralkh/seerai

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for arboreto

README.md
[![agentmods](https://agentmods.dev/badge/skills/dralkh/seerai/arboreto/github.svg)](https://agentmods.dev/skills/dralkh/seerai/arboreto)
Your own site
<a href="https://agentmods.dev/skills/dralkh/seerai/arboreto"><img src="https://agentmods.dev/badge/skills/dralkh/seerai/arboreto/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for arboreto

Your own site · 80×15
<a href="https://agentmods.dev/skills/dralkh/seerai/arboreto"><img src="https://agentmods.dev/badge/skills/dralkh/seerai/arboreto.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 66 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,108 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin 100% copy Near-identical to another mod in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00066 $0.02108
Opus 5 $0.00033 $0.01054
Sonnet 5 $0.00013 $0.00422
Haiku 4.5 $0.00007 $0.00211

Measured 9d ago against content hash bbaf279d7142, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-08, from the pricing page.

Security

Grade A, and why

arboreto scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (scripts/basic_grn_inference.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

This is a copy

100% identical to arboreto — 20 lines differ, which has more behind it and is treated as the original. This page carries a canonical link to it rather than competing with it.

skills/arboreto/SKILL.md · 266 lines

How it starts

The opening of the file, as written. The whole thing — 266 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Arboreto

Overview

Arboreto is a Python library from Aerts Lab for inferring gene regulatory networks (GRNs) from gene expression data. It parallelizes tree-based ensemble regression (GRNBoost2, GENIE3) with Dask across local cores or remote clusters.

Core capability: Identify which transcription factors (TFs) regulate which target genes based on expression patterns across observations (cells, samples, conditions).

Upstream: PyPI 0.1.6 (2021-02-09, latest). Docs: arboreto.readthedocs.io. Primary downstream consumer: pySCENIC.

Quick Start

Install arboreto:

uv pip install arboreto

Basic GRN inference:

import pandas as pd
from arboreto.algo import grnboost2

if __name__ == '__main__':
    # Load expression data (genes as columns)
    expression_matrix = pd.read_csv('expression_data.tsv', sep='\t')

    # Infer regulatory network
    network = grnboost2(expression_data=expression_matrix)

    # Save results (TF, target, importance)
    network.to_csv('network.tsv', sep='\t', index=False, header=False)

Critical: Always use if __name__ == '__main__': guard because Dask spawns new processes.

Core Capabilities

1. Basic GRN Inference

For standard GRN inference workflows including:

  • Input data preparation (Pandas DataFrame or NumPy array)
  • Running inference with GRNBoost2 or GENIE3
  • Filtering by transcription factors
  • Output format and interpretation

See: references/basic_inference.md

Use the ready-to-run script: scripts/basic_grn_inference.py for standard inference tasks:

python scripts/basic_grn_inference.py expression_data.tsv output_network.tsv --tf-file tfs.txt --seed 777 --limit 5000

2. Algorithm Selection

Arboreto provides two algorithms:

GRNBoost2 (Recommended):

  • Fast gradient boosting-based inference
  • Optimized for large datasets (10k+ observations)
  • Default choice for most analyses

Read the full file on GitHub · 266 lines

Files

What ships with it

4 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 266 lines · 66 tokens per session scan A bbaf279d7142

Subscribe to this mod's changes

arboreto is a skill published in the GitHub repository dralkh/seerai (76 stars, last pushed 2mo ago), licensed MIT. It adds 66 tokens to every session and 2,108 once invoked, about $0.0003 per session on Opus 5. A static security scan graded it A with 0 findings. It is 100% identical to arboreto, differing in 20 lines, and is treated as a copy.

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