FridrichMethod/awesome-skills

Curated, auto-synced collection of 2,000+ Claude Code & Codex skills for AI4Protein, bioinformatics, AI development, and academic paper writing. One curl command installs them all.

15Stars on the repository
200Mods indexed here, across every type
6d agoLast push, which is what freshness is scored on
customA LICENSE file GitHub cannot name, so bodies are not copied

autoskill

97

FridrichMethod/awesome-skills

Skill Claude Code

Observe the user's screen via screenpipe, detect repeated research workflows, match them against existing scientific-agent-skills, and draft new skills (or composition recipes that chain existing ones) for the patterns not yet covered. Use when the user asks to analyze their recent work and propose skills based on…

not rated 15 +1 changed 4d ago B 123 tokens

avoid-ai-writing

98

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Audit and rewrite prose so it stops reading as machine-generated. Use this skill when asked to remove AI-isms, clean up AI writing, edit a draft for AI tells, audit a README, changelog, release note, PR description, or blog post for machine-sounding prose, or make text sound less like AI. Supports a detect-only mode…

not rated 15 +1 6d ago A 93 tokens

backend-patterns

99

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Backend architecture patterns, API design, database optimization, and server-side best practices for Node.js, Express, and Next.js API routes.

not rated 15 +1 6d ago A 31 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Build robust backtesting systems for trading strategies with proper handling of look-ahead bias, survivorship bias, and transaction costs. Use when developing trading algorithms, validating strategies, or building backtesting infrastructure.

not rated 15 +1 6d ago A 45 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, 684 genes) and NEGv1 non-essentials (Hart 2014, 927…

not rated 15 +1 6d ago A 220 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Annotate bacterial and archaeal genomes and plasmids with Bakta's Prodigal/HMM/diamond pipeline. Identifies CDS, ncRNA, tRNA, rRNA, tmRNA, sORFs, CRISPR arrays, oriC/oriV/oriT, and gaps against a curated UniRef-derived database. Produces NCBI-compatible GFF3, GenBank, EMBL, JSON, FASTA, TSV, and a circular genome…

not rated 15 +1 6d ago A 125 tokens

bio-bam-statistics

103

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Generate alignment statistics using samtools flagstat, stats, depth, coverage, and mosdepth. Use when assessing alignment quality, calculating coverage, or generating QC reports.

not rated 15 +1 6d ago A 39 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10)…

not rated 15 +1 6d ago A 218 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions 5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and…

not rated 15 +1 6d ago A 231 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Basecalls raw Oxford Nanopore signal (POD5/FAST5) into reads with Dorado, choosing the chemistry-matched model and accuracy tier (fast/hac/sup), requesting modified bases (5mCG5hmCG, 6mA, m6A) at basecall time, and handling duplex, demultiplexing, trimming, and HERRO read correction. Covers why the model+version is an…

not rated 15 +1 6d ago A 171 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Master defensive Bash programming techniques for production-grade scripts. Use when writing robust shell scripts, CI/CD pipelines, or system utilities requiring fault tolerance and safety.

not rated 15 +1 6d ago A 36 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS…

not rated 15 +1 changed 4d ago A 185 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Designs genomics experiments so technical nuisance variation (batch, lane, plate, flow cell, operator, reagent lot, processing day) is balanced against the biological variable of interest and therefore estimable rather than confounded, using constrained sample-to-batch assignment (designit, OSAT), the…

not rated 15 +1 6d ago A 200 tokens

bio-batch-downloads

110

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Download large datasets from NCBI efficiently using EPost, history server, batching, rate limiting, and retry logic. Use when bulk-fetching tens of thousands of sequences, pulling all results of a large ESearch, designing reproducible pipelines, comparing E-utilities to NCBI Datasets v2 CLI, or implementing…

not rated 15 +1 6d ago A 104 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Integrate multiple scRNA-seq samples or batches with Harmony, scVI/scANVI, Seurat (CCA/RPCA), fastMNN, Scanorama, or BBKNN. Resolves which method to use for the dataset size and design, how strongly to correct, when integration is the wrong move (confounded batch/biology), how to score integration with scIB metrics…

not rated 15 +1 6d ago A 124 tokens

bio-batch-processing

112

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Process many sequence files in batch (count, merge, split, convert, summarize) with memory-safe streaming and on-disk indexing using Biopython, pysam, or pyfastx. Use when iterating over a directory of FASTA/FASTQ files, merging or splitting datasets, building random access across many or huge files, or automating…

not rated 15 +1 6d ago A 83 tokens

bats-testing-patterns

113

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Master Bash Automated Testing System (Bats) for comprehensive shell script testing. Use when writing tests for shell scripts, CI/CD pipelines, or requiring test-driven development of shell utilities.

not rated 15 +1 6d ago D 42 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Frames Bayesian phylogenetics as approximating a posterior distribution over trees conditioned on data AND priors via an MCMC that must be proven to have converged, using MrBayes, BEAST2, RevBayes, and PhyloBayes-MPI. Covers why convergence (ESS, PSRF, ASDSF, topology vs scalar) is the load-bearing claim, why…

not rated 15 +1 6d ago A 198 tokens

bayesian-optimizer

115

FridrichMethod/awesome-skills

Skill Claude Code

Skill "bayesian-optimizer" from FridrichMethod/awesome-skills, covering copyright notice, copyright (c) 2026 md babu mia, phd, all rights reserved, this code is proprietary and confidential and provenance: authenticated by md babu mia.

not rated 15 +1 6d ago A 8 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and…

not rated 15 +1 6d ago A 164 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Optimize Bazel builds for large-scale monorepos. Use when configuring Bazel, implementing remote execution, or optimizing build performance for enterprise codebases.

not rated 15 +1 6d ago A 36 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

CLI for VCF/BCF: filter, merge, annotate, query, normalize, compute stats. Core post-variant-calling: quality filtering, multi-sample merging, rsID annotation, genotype extraction. Samtools companion in HTSlib. Use GATK for complex indel realignment during calling; use VCFtools for population genetics stats.

not rated 15 +1 6d ago A 82 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Bead-based signal normalization and cross-batch harmonization for CyTOF and high-parameter cytometry - EQ four-element bead normalization of instrument sensitivity drift (CATALYST normCytof, premessa), and reference-anchor cross-batch normalization (CytoNorm, per-cluster quantile splines). Covers the distinction…

not rated 15 +1 6d ago A 142 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Handles BED-format genomic intervals (BED3 through BED12, narrowPeak/broadPeak) and the coordinate-system substrate the whole interval category rests on, with bedtools (CLI) and pybedtools/pyranges/pandas (Python). Covers the 0-based half-open vs 1-based-closed convention boundary and the start-1/end-unchanged…

not rated 15 +1 6d ago A 197 tokens

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