Getting it into your agent
One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.
npx skills add GPTomics/bioSkills --skill adaptive-designsgit clone --depth 1 https://github.com/GPTomics/bioSkillsWrote this? Show the measurements
A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.
[](https://agentmods.dev/skills/gptomics/bioskills/adaptive-designs)<a href="https://agentmods.dev/skills/gptomics/bioskills/adaptive-designs"><img src="https://agentmods.dev/badge/skills/gptomics/bioskills/adaptive-designs/github.svg" alt="Measured on agentmods" height="20"></a>Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.
<a href="https://agentmods.dev/skills/gptomics/bioskills/adaptive-designs"><img src="https://agentmods.dev/badge/skills/gptomics/bioskills/adaptive-designs.svg" alt="Reviewed on agentmods" width="80" height="20"></a>What it costs to keep this loaded
Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.
| Model | Per session | Once invoked |
|---|---|---|
| Fable 5.1 | $0.00147 | $0.07705 |
| Opus 5 | $0.00073 | $0.03853 |
| Sonnet 5 | $0.00029 | $0.01541 |
| Haiku 4.5 | $0.00015 | $0.00771 |
Grade A, and why
bio-clinical-biostatistics-adaptive-designs scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 6d ago.
A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.
Nothing flagged
None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.
Copies of this mod
1 near-identical copy found in the catalogue:
- bio-clinical-biostatistics-adaptive-designs — 97% identical, 12 lines differ
How it starts
The opening of the file, as written. The whole thing — 451 lines — stays where its author put it; the contents beside it link to each section on GitHub.
Version Compatibility
Reference examples tested with: R rpact 4.2+ (Wassmer/Brannath), gsDesign 3.6+ and gsDesign2 1.1+ (Anderson/Merck), adaptr, simtrial. Commercial: East/EastHorizon (Cytel), ADDPLAN (ICON), FACTS (Berry Consultants).
Before using code patterns, verify installed versions match. If versions differ:
- R:
packageVersion('<pkg>')then?function_name - Python adaptive packages are limited; R is the regulatory de facto standard
If code throws an error, introspect the installed package and adapt the example to match the actual API rather than retrying.
Adaptive Clinical Trial Designs
"Design an adaptive trial" -> Pre-specify a design with one or more interim adaptations (early stopping, sample-size re-estimation, treatment selection, population enrichment, randomisation ratio changes) that strongly controls Type-I error at the trial-wide level via combination tests or the Conditional Rejection Probability principle.
Regulatory Status -- The 2024-2026 Landscape
FDA 2019 Final Adaptive Designs Guidance (Federal Register 2019-25986, Dec 2 2019) finalised the 2010 and 2018 drafts. Recognises 5 design types: group-sequential, blinded SSR, unblinded SSR, adaptive enrichment, adaptive randomisation.
FDA 2022 Final Master Protocols Guidance (March 2022, NOT 2018 — common citation error): basket (one drug, many diseases), umbrella (multiple drugs, one disease), platform (perpetual, drugs enter/exit).
ICH E20 Adaptive Clinical Trials: Step 2b draft June 25 2025; Step 3 public consultation (EU deadline Nov 30 2025; FDA Federal Register Sept 30 2025); Step 4 final expected in 2026. As of May 2026, ICH E20 is NOT final. The EFPIA/PhRMA position paper preceded the formal ICH work; Berry Consultants public comment letter is one of the more important submissions.
FDA CDER Bayesian Methodology Draft (Jan 2026) (FDA-2025-D-3217): first-ever drug-side Bayesian guidance; permits Bayesian primary inference in pivotals with simulation-based Type-I error calibration.
What ships with it
2 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.
What this file has done since we first saw it
Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.
- 6d ago First seen · 451 lines · 147 tokens per session scan A b8424144ac6a
bio-clinical-biostatistics-adaptive-designs is a skill published in the GitHub repository GPTomics/bioSkills (1,199 stars, last pushed 25d ago), licensed MIT. It adds 147 tokens to every session and 7,705 once invoked, about $0.0007 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.
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