bio-clip-seq-clip-deep-learning

bio-clip-seq-clip-deep-learning is a skill for Claude Code, Codex from GPTomics/bioSkills. It costs 123 tokens per session (4,640 once invoked), scanned A, original, MIT.

A machine-learning workflow that predicts where an RNA-binding protein may attach based on RNA sequence and, in some models, RNA structure. It learns these patterns from binding data such as CLIP-seq.

In plain words
What is it for?
Use it to predict binding sites, study variant effects, interpret model decisions, or adapt models using CLIP-seq and related binding datasets.
Why use it?
It extends binding analysis to sequences that were not directly measured and helps estimate how DNA or RNA variants could change protein binding.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to predict binding sites, study variant effects, interpret model decisions, or adapt models using CLIP-seq and related binding datasets.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/gptomics/bioskills/clip-deep-learning
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add GPTomics/bioSkills --skill clip-deep-learning
Clone the repo
git clone --depth 1 https://github.com/GPTomics/bioSkills

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for bio-clip-seq-clip-deep-learning

README.md
[![agentmods](https://agentmods.dev/badge/skills/gptomics/bioskills/clip-deep-learning/github.svg)](https://agentmods.dev/skills/gptomics/bioskills/clip-deep-learning)
Your own site
<a href="https://agentmods.dev/skills/gptomics/bioskills/clip-deep-learning"><img src="https://agentmods.dev/badge/skills/gptomics/bioskills/clip-deep-learning/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for bio-clip-seq-clip-deep-learning

Your own site · 80×15
<a href="https://agentmods.dev/skills/gptomics/bioskills/clip-deep-learning"><img src="https://agentmods.dev/badge/skills/gptomics/bioskills/clip-deep-learning.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 123 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 4,640 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00123 $0.04640
Opus 5 $0.00062 $0.02320
Sonnet 5 $0.00025 $0.00928
Haiku 4.5 $0.00012 $0.00464

Measured 7d ago against content hash d199c7a0f7a5, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-10, from the pricing page.

Security

Grade A, and why

bio-clip-seq-clip-deep-learning scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 7d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (examples/train_rnaprot.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

Copies of this mod

1 near-identical copy found in the catalogue:

clip-seq/clip-deep-learning/SKILL.md · 316 lines

How it starts

The opening of the file, as written. The whole thing — 316 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Version Compatibility

Reference examples tested with: RBPNet (Horlacher et al 2023 github), RNAProt 0.5+, GraphProt2 (Uhl et al 2021 github), DeepCLIP 1.0+ (Gronning 2020), DeepRiPe (Ohler lab), pytorch 2.2+, tensorflow 2.15+, scikit-learn 1.4+, biopython 1.83+, transformers 4.40+ (for RNA foundation models).

Before using code patterns, verify installed versions match. If versions differ:

  • Python: pip show <package> then help(module.function) to check signatures
  • Frameworks: check pytorch / tensorflow versions; reproducibility depends on framework version

If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying.

CLIP-seq Deep Learning

"Predict RBP binding from RNA sequence using deep learning" -> Train or apply neural networks that learn the sequence (and optionally structure) preference of an RBP from CLIP-seq peaks or single-nucleotide crosslink sites. The output is per-base or per-site binding probability for any input sequence, enabling: (a) variant-effect prediction at heterozygous SNPs; (b) in silico binding-site discovery on transcripts not covered by CLIP; (c) systematic comparison across RBPs via shared model architectures; (d) interpretation via attribution / saliency to recover RBP-specific motifs and structural preferences. Modern models (RBPNet 2023) predict per-nucleotide crosslink count distributions rather than binary peak/non-peak, providing single-nt resolution outputs.

  • Python (RBPNet sequence-to-CL signal): import rbpnet; model = rbpnet.load_pretrained('RBP_name'); predictions = model.predict(sequence) produces per-base CL count distribution
  • Python (RNAProt RNN classifier): RNAProt train -i peaks.bed -t background.bed -g genome.fa -o model/ then RNAProt predict -m model/ -i query_sequences.fa -o predictions.tsv
  • Python (GraphProt2 GCN with structure): graphprot2 train -i peaks.bed -bg shuffled.bed -g genome.fa --structure -o model/
  • Python (DeepCLIP for binding probability): deepclip --train --train_data train.fa --validation_data val.fa --predict --predict_data test.fa --output_dir output/
  • Python (DeepRiPe multi-modal CNN): from deepripe import DeepRiPe; model.train(X_train, y_train); predictions = model.predict(X_test)

Read the full file on GitHub · 316 lines

Files

What ships with it

2 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 7d ago First seen · 316 lines · 123 tokens per session scan A d199c7a0f7a5

Subscribe to this mod's changes

bio-clip-seq-clip-deep-learning is a skill published in the GitHub repository GPTomics/bioSkills (1,199 stars, last pushed 26d ago), licensed MIT. It adds 123 tokens to every session and 4,640 once invoked, about $0.0006 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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