molfeat

molfeat is a skill for Claude Code from K-Dense-AI/drug-discovery-agent-skills. It costs 165 tokens per session (5,068 once invoked), scanned A, original, MIT.

A molecular-filtering library for deciding which compounds are worth examining further in drug discovery. It applies drug-likeness guidelines, structural-warning lists, chemical-group checks, and molecular-complexity measures.

In plain words
What is it for?
Use it to apply Lipinski, Veber, CNS, lead-like, and related rules; flag PAINS and other structural alerts; calculate complexity measures; and prioritise compounds.
Why use it?
Large compound collections often contain molecules with unsuitable properties or chemical groups linked to misleading test results. Filtering helps reduce the list before hit-to-lead or lead-optimisation work.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Good fit Use it to apply Lipinski, Veber, CNS, lead-like, and related rules; flag PAINS and other structural alerts; calculate complexity measures; and prioritise compounds.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/k-dense-ai/drug-discovery-agent-skills/molfeat
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add K-Dense-AI/drug-discovery-agent-skills --skill molfeat
Clone the repo
git clone --depth 1 https://github.com/K-Dense-AI/drug-discovery-agent-skills

Made for: Claude Code.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for molfeat

README.md
[![agentmods](https://agentmods.dev/badge/skills/k-dense-ai/drug-discovery-agent-skills/molfeat/github.svg)](https://agentmods.dev/skills/k-dense-ai/drug-discovery-agent-skills/molfeat)
Your own site
<a href="https://agentmods.dev/skills/k-dense-ai/drug-discovery-agent-skills/molfeat"><img src="https://agentmods.dev/badge/skills/k-dense-ai/drug-discovery-agent-skills/molfeat/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for molfeat

Your own site · 80×15
<a href="https://agentmods.dev/skills/k-dense-ai/drug-discovery-agent-skills/molfeat"><img src="https://agentmods.dev/badge/skills/k-dense-ai/drug-discovery-agent-skills/molfeat.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 165 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 5,068 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00165 $0.05068
Opus 5 $0.00082 $0.02534
Sonnet 5 $0.00033 $0.01014
Haiku 4.5 $0.00016 $0.00507

Measured 12d ago against content hash 04b9fa8ad938, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

molfeat scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 12d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/molfeat/SKILL.md · 384 lines

How it starts

The opening of the file, as written. The whole thing — 384 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Molfeat - Molecular Featurization Hub

Overview

Molfeat turns molecules (SMILES strings or RDKit/datamol Mol objects) into numerical representations for machine learning: fingerprints, descriptors, pharmacophores, shape descriptors, and pretrained neural embeddings, all behind one scikit-learn-compatible transformer interface with state serialization and caching.

Current baseline (verified 2026-08-16): molfeat 0.11.0 (May 2025) is still the latest PyPI and GitHub release; the repository has had no commits since. All examples in this skill were executed against 0.11.0 on Python 3.10 with datamol 0.12.5, RDKit 2026.03.5, numpy 2.2.6 and torch 2.13.0. Python 3.11+ is not installable (requires-python = ">=3.9,<3.11").

The Python cap isolates this skill from the rest of the bundle. Nothing else here needs an interpreter below 3.11, so molfeat requires its own environment and cannot share one with admet-prediction (3.11+), pytdc, or deepchem. That is manageable for a featurisation step that writes a matrix to disk, and painful for anything interactive. For new work where the featuriser is not itself the point, RDKit or datamol fingerprints plus a Chemprop or scikit-learn model reach the same place without the constraint; use molfeat when you specifically want its breadth of featurisers behind one interface. 0.11.0 loads pretrained models in memory, sets base models to eval mode, and moved the model store to a Cloudflare HTTP bucket (PR #115) — that last change broke store downloads for the HuggingFace models (see Pretrained models).

When to Use This Skill

  • Converting SMILES into ML-ready feature matrices (QSAR/QSPR, ADMET, activity prediction)
  • Virtual screening: featurize a library, score it with a trained model
  • Similarity searching and chemical-space analysis (clustering, UMAP/t-SNE)
  • Benchmarking several representations against each other on the same task
  • Building reproducible featurization pipelines that can be serialized and reloaded

Read the full file on GitHub · 384 lines

Files

What ships with it

4 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 12d ago First seen · 384 lines · 165 tokens per session scan A 04b9fa8ad938

Subscribe to this mod's changes

molfeat is a skill published in the GitHub repository K-Dense-AI/drug-discovery-agent-skills (28 stars, last pushed 5d ago), licensed MIT. It adds 165 tokens to every session and 5,068 once invoked, about $0.0008 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.