Borrowing it
Nothing to install: this file belongs to monarch-initiative/dismech. Take a copy, put it at the same path in your own repository, and replace the rules that are about this project with yours.
curl -O https://raw.githubusercontent.com/monarch-initiative/dismech/main/.claude/skills/noncoding-variant-impact/SKILL.mdgit clone --depth 1 https://github.com/monarch-initiative/dismechWrote this? Show the measurements
A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.
[](https://agentmods.dev/skills/monarch-initiative/dismech/noncoding-variant-impact)<a href="https://agentmods.dev/skills/monarch-initiative/dismech/noncoding-variant-impact"><img src="https://agentmods.dev/badge/skills/monarch-initiative/dismech/noncoding-variant-impact/github.svg" alt="Measured on agentmods" height="20"></a>Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.
<a href="https://agentmods.dev/skills/monarch-initiative/dismech/noncoding-variant-impact"><img src="https://agentmods.dev/badge/skills/monarch-initiative/dismech/noncoding-variant-impact.svg" alt="Reviewed on agentmods" width="80" height="20"></a>What it costs to keep this loaded
Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.
| Model | Per session | Once invoked |
|---|---|---|
| Fable 5.1 | $0.00045 | $0.02113 |
| Opus 5.5 | $0.00018 | $0.00845 |
| Sonnet 5.5 | $0.00009 | $0.00423 |
| Haiku 4.5 | $0.00005 | $0.00211 |
Grade A, and why
noncoding-variant-impact scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 1mo ago.
A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.
Nothing flagged
None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.
How it starts
The opening of the file, as written. The whole thing — 169 lines — stays where its author put it; the contents beside it link to each section on GitHub.
Curating noncoding variant impact
Use the existing fields in the schema. Keep classifications small and optional; preserve evidence-specific detail in descriptions. A noncoding location alone does not establish a regulatory mechanism. Splicing, RNA stability, translation, and noncoding-RNA defects may require different causal steps. An SV can also overlap coding genes while acting primarily through regulation.
Keep the claims separate
| Claim | Where to record it |
|---|---|
| Physical alteration | Variant.variant_type; initiating node's genetic_context.variant_type |
| Sequence features overlapped | genomic_contexts on either of those objects |
| Named affected region and its position | affected_regions on Variant, GeneticContext, or a regional Genetic record |
| Gene whose expression is affected or proposed to be affected | Variant.regulatory_target_gene; gene annotation on the downstream expression node |
| Element and direct molecular effect | functional_effects[].regulatory_element_type, regulatory_mechanism, and description |
| Expression pattern | regulatory_category on Variant, FunctionalEffect, or Pathophysiology, when supported |
| Quantitative process change | Biological-process descriptor modifier: INCREASED or DECREASED |
| Downstream consequences | Separate, evidence-backed pathophysiology nodes and causal edges |
variant_type and genomic_contexts use human-readable static enum values,
such as deletion, single nucleotide variant, intron, or "5' UTR".
The Sequence Ontology mappings live in the schema; do not add ID/label pairs
to these fields. Gene and process annotations still use their normal descriptors.
Contexts can overlap and depend on the transcript. Identify the relevant
genes/transcripts in description; an intronic host gene may differ from the
regulatory target. Prefer the appropriate UTR context when the overlap is known
to be untranslated sequence of a protein-coding transcript, including a wholly
untranslated exon such as APC exon 1B. Use noncoding exon for an entire exon
without codons when no more specific UTR context applies. Omit unknown contexts.
Only put contexts shared by the represented alleles on a shared initiating node.
These classifications neither identify an enhancer nor encode genomic coordinates.
What this file has done since we first saw it
Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.
- 1mo ago First seen · 169 lines · 45 tokens per session scan A 6ec24077ead3
noncoding-variant-impact is a skill published in the GitHub repository monarch-initiative/dismech (69 stars, last pushed today), licensed BSD-3-Clause. It adds 45 tokens to every session and 2,113 once invoked, about $0.0002 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-23.
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