neuropixels-analysis

An analysis workflow for Neuropixels recordings, which are high-density electrical measurements of activity from many neurons at once.

In plain words
What is it for?
Use it to load SpikeGLX, Open Ephys, or NWB files; preprocess and correct motion; sort spikes; measure unit quality; review results; and export data to Phy or NWB.
Why use it?
It organizes the steps needed to turn raw recordings into cleaned, sorted, checked, and usable neural data.

Skill for Claude CodeCodex

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add skills/synthetic-sciences/openscience/neuropixels-analysis
Any agent
npx skills add synthetic-sciences/openscience --skill neuropixels-analysis
Clone the repo
git clone --depth 1 https://github.com/synthetic-sciences/openscience

Made for: Claude Code, Codex.

Per session 109 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,932 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. Scan, not verified.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5 $0.00109 $0.02932
Opus 5 $0.00055 $0.01466
Sonnet 5 $0.00022 $0.00586
Haiku 4.5 $0.00011 $0.00293

Measured 3d ago against content hash 5e73ee7c26d3, method: parsed. Prices are Anthropic first-party input rates as of 2026-08-30, from the pricing page.

Security

Grade A, and why

neuropixels-analysis scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 3d ago.

The scan reads SKILL.md. This mod also ships 7 executable files (assets/analysis_template.py, scripts/compute_metrics.py, scripts/explore_recording.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

Copies of this mod

1 near-identical copy found in the catalogue:

backend/cli/skills/biology/neuropixels-analysis/SKILL.md · 350 lines

How it starts

The opening of the file, as written. The whole thing — 350 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Neuropixels Data Analysis

Overview

Comprehensive toolkit for analyzing Neuropixels high-density neural recordings using current best practices from SpikeInterface, Allen Institute, and International Brain Laboratory (IBL). Supports the full workflow from raw data to publication-ready curated units.

When to Use This Skill

This skill should be used when:

  • Working with Neuropixels recordings (.ap.bin, .lf.bin, .meta files)
  • Loading data from SpikeGLX, Open Ephys, or NWB formats
  • Preprocessing neural recordings (filtering, CAR, bad channel detection)
  • Detecting and correcting motion/drift in recordings
  • Running spike sorting (Kilosort4, SpykingCircus2, Mountainsort5)
  • Computing quality metrics (SNR, ISI violations, presence ratio)
  • Curating units using Allen/IBL criteria
  • Creating visualizations of neural data
  • Exporting results to Phy or NWB

Supported Hardware & Formats

Probe Electrodes Channels Notes
Neuropixels 1.0 960 384 Requires phase_shift correction
Neuropixels 2.0 (single) 1280 384 Denser geometry
Neuropixels 2.0 (4-shank) 5120 384 Multi-region recording
Format Extension Reader
SpikeGLX .ap.bin, .lf.bin, .meta si.read_spikeglx()
Open Ephys .continuous, .oebin si.read_openephys()
NWB .nwb si.read_nwb()

Quick Start

Basic Import and Setup

import spikeinterface.full as si
import neuropixels_analysis as npa

# Configure parallel processing
job_kwargs = dict(n_jobs=-1, chunk_duration='1s', progress_bar=True)

Loading Data

# SpikeGLX (most common)
recording = si.read_spikeglx('/path/to/data', stream_id='imec0.ap')

# Open Ephys (common for many labs)
recording = si.read_openephys('/path/to/Record_Node_101/')

# Check available streams
streams, ids = si.get_neo_streams('spikeglx', '/path/to/data')
print(streams)  # ['imec0.ap', 'imec0.lf', 'nidq']

# For testing with subset of data
recording = recording.frame_slice(0, int(60 * recording.get_sampling_frequency()))

Read the full file on GitHub · 350 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 3d ago First seen · 350 lines · 109 tokens per session scan A 5e73ee7c26d3

Subscribe to this mod's changes

neuropixels-analysis is a skill published in the GitHub repository synthetic-sciences/openscience (3,385 stars, last pushed yesterday), licensed Apache-2.0. It adds 109 tokens to every session and 2,932 once invoked, about $0.0005 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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