chai1

chai1 is a skill for Claude Code, Codex from UnicomAI/wanwu. It costs 98 tokens per session (1,280 once invoked), scanned A, a copy of chai1, Apache-2.0.

A tool workflow for predicting the three-dimensional structure of complexes made from proteins, DNA, RNA, and small-molecule compounds. FASTA is a text format for describing biological sequences; the workflow accepts a multi-entity FASTA file and produces structure files and confidence scores.

In plain words
What is it for?
Use it to model antibody–antigen, protein–protein, protein–RNA, protein–DNA, or protein–ligand complexes. It can be embedded in a Python loop to score and rank candidate structures.
Why use it?
It helps researchers estimate how several biological molecules or a designed binder may fit together before laboratory testing. Running it on candidate complexes can support an initial design filter.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

About the project

Wanwu is an enterprise platform for building AI agents, workflows, retrieval-augmented applications, and managing models in multi-tenant environments. It is designed for developers and enterprise teams delivering AI applications and integrations. The catalogue entries provide skills and agents for using the platform.

UnicomAI/wanwu · 2,458 stars · on GitHub

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add skills/unicomai/wanwu/chai1
Any agent
npx skills add UnicomAI/wanwu --skill chai1
Clone the repo
git clone --depth 1 https://github.com/UnicomAI/wanwu

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for chai1

README.md
[![agentmods](https://agentmods.dev/badge/skills/unicomai/wanwu/chai1.svg)](https://agentmods.dev/skills/unicomai/wanwu/chai1)
Your own site
<a href="https://agentmods.dev/skills/unicomai/wanwu/chai1"><img src="https://agentmods.dev/badge/skills/unicomai/wanwu/chai1.svg" alt="Measured on agentmods" height="20"></a>
Per session 98 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,280 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. Scan, not verified.
Origin 100% copy Near-identical to another mod in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00098 $0.01280
Opus 5 $0.00049 $0.00640
Sonnet 5 $0.00020 $0.00256
Haiku 4.5 $0.00010 $0.00128

Measured 6d ago against content hash 14c7b111475c, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-06, from the pricing page.

Security

Grade A, and why

chai1 scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 6d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

This is a copy

100% identical to chai1 — 8 lines differ, which has more behind it and is treated as the original. This page carries a canonical link to it rather than competing with it.

configs/microservice/bff-service/configs/agent-skills/claude-science/chai1/SKILL.md · 112 lines

How it starts

The opening of the file, as written. The whole thing — 112 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Chai-1

Chai-1 is an all-atom diffusion co-folder in the same family as Boltz-2 and AlphaFold3: a multi-entity FASTA in, mmCIF plus pTM/ipTM/pLDDT out, with protein, RNA, DNA, and SMILES-ligand chains all first-class. It and boltz cover the same surface; running both and keeping designs that pass either is a common consensus filter, and Chai's Python entry point makes it the easier of the two to embed in a loop. Code and weights are Apache-2.0 — commercial use including drug discovery is explicitly permitted (github.com/chaidiscovery/chai-lab).

Running it

from pathlib import Path
from chai_lab.chai1 import run_inference

Path("complex.fasta").write_text("""
>protein|name=target
MVTPEGNVSLVDESLLVGVTDEDRAVRS...
>protein|name=binder
AIQRTPKIQVYSRHPAENG...
>ligand|name=cofactor
CCCCCCCCCCCCCC(=O)O
""".strip())

candidates = run_inference(
    fasta_file=Path("complex.fasta"),
    output_dir=Path("out/"),
    num_trunk_recycles=3,
    num_diffn_timesteps=200,
    seed=42,
    device="cuda:0",
    use_esm_embeddings=True,
)
print([rd.aggregate_score.item() for rd in candidates.ranking_data])

The FASTA header is >{entity_type}|name={id} with entity_type ∈ {protein, rna, dna, ligand}; ligand records carry a SMILES string as the sequence body, and modified residues are written inline as ...AAK(SEP)AAG.... From the shell the same job is chai-lab fold complex.fasta out/ --use-msa-server. Without --use-msa-server (or use_msa_server=True in Python) the model runs on ESM embeddings alone, which is faster but typically a few ipTM points behind the MSA-backed run.

output_dir receives pred.model_idx_{0..4}.cif plus a matching scores.model_idx_{N}.npz per sample with aggregate_score, ptm, iptm, per_chain_ptm, and clash flags. Rank by aggregate_score; treat iptm > 0.5 as a soft pass for an interface. The function refuses a non-empty output_dir, so clear or rotate it between calls.

Unset CHAI_DOWNLOADS_DIR fails mid-run with PermissionError on a read-only image

Read the full file on GitHub · 112 lines

Files

What ships with it

1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 6d ago First seen · 112 lines · 98 tokens per session scan A 14c7b111475c

Subscribe to this mod's changes

chai1 is a skill published in the GitHub repository UnicomAI/wanwu (2,458 stars, last pushed yesterday), licensed Apache-2.0. It adds 98 tokens to every session and 1,280 once invoked, about $0.0005 per session on Opus 5. A static security scan graded it A with 0 findings. It is 100% identical to chai1, differing in 8 lines, and is treated as a copy.

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