solublempnn

solublempnn is a skill for Claude Code, Codex from UnicomAI/wanwu. It costs 96 tokens per session (1,072 once invoked), scanned A, a copy of solublempnn, Apache-2.0.

A protein-design tool that chooses amino-acid sequences for a supplied protein backbone, using a model trained on proteins that dissolve more readily in water.

In plain words
What is it for?
Use it to redesign protein sequences for better soluble production from a backbone structure, especially for cytosolic expression.
Why use it?
It helps when standard ProteinMPNN designs tend to clump together or form insoluble inclusion bodies when produced in another organism.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

About the project

Wanwu is an enterprise platform for building AI agents, workflows, retrieval-augmented applications, and managing models in multi-tenant environments. It is designed for developers and enterprise teams delivering AI applications and integrations. The catalogue entries provide skills and agents for using the platform.

UnicomAI/wanwu · 2,458 stars · on GitHub

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add skills/unicomai/wanwu/solublempnn
Any agent
npx skills add UnicomAI/wanwu --skill solublempnn
Clone the repo
git clone --depth 1 https://github.com/UnicomAI/wanwu

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for solublempnn

README.md
[![agentmods](https://agentmods.dev/badge/skills/unicomai/wanwu/solublempnn.svg)](https://agentmods.dev/skills/unicomai/wanwu/solublempnn)
Your own site
<a href="https://agentmods.dev/skills/unicomai/wanwu/solublempnn"><img src="https://agentmods.dev/badge/skills/unicomai/wanwu/solublempnn.svg" alt="Measured on agentmods" height="20"></a>
Per session 96 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,072 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. Scan, not verified.
Origin 100% copy Near-identical to another mod in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00096 $0.01072
Opus 5 $0.00048 $0.00536
Sonnet 5 $0.00019 $0.00214
Haiku 4.5 $0.00010 $0.00107

Measured 6d ago against content hash c5c9b5cba266, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-06, from the pricing page.

Security

Grade A, and why

solublempnn scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 6d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

This is a copy

100% identical to solublempnn — 0 lines differ, which has more behind it and is treated as the original. This page carries a canonical link to it rather than competing with it.

configs/microservice/bff-service/configs/agent-skills/claude-science/solublempnn/SKILL.md · 88 lines

How it starts

The opening of the file, as written. The whole thing — 88 lines — stays where its author put it; the contents beside it link to each section on GitHub.

SolubleMPNN

SolubleMPNN is not a separate package — it is the ProteinMPNN architecture retrained on a soluble-PDB subset, which shifts the output distribution away from the surface hydrophobics that the full-PDB model happily places (because many of them are buried at crystallographic or membrane interfaces in the training set). Reach for it when the goal is soluble yield in a heterologous host; stick with proteinmpnn when native-like recovery matters more, since the soluble prior trades a few points of recovery for the surface bias. Code and weights are MIT (github.com/dauparas/ProteinMPNN, soluble_model_weights; also exposed via github.com/dauparas/LigandMPNN). The model is small enough to run on CPU — for a handful of sequences on one backbone that is seconds and usually faster than dispatching; a GPU helps for batched campaigns. Either way the repo is cloned in-job (no PyPI dist; checkpoints bundled).

Running it

pip install torch numpy   # if not already present
git clone --depth 1 https://github.com/dauparas/ProteinMPNN.git proteinmpnn
cd proteinmpnn
python protein_mpnn_run.py \
  --pdb_path backbone.pdb --pdb_path_chains "A" \
  --out_folder out --num_seq_per_target 16 \
  --sampling_temp "0.1" --use_soluble_model

The runner uses repo-relative imports, so the cd line is load-bearing — invoking the script by absolute path from elsewhere fails with ModuleNotFoundError. If you want threaded designed-sequence PDBs as well, the LigandMPNN runner accepts --model_type soluble_mpnn (see ligandmpnn for that path; it needs ProDy in addition to torch). The flag surface is otherwise identical to proteinmpnn (or ligandmpnn for the second form), including the string-typed temperature and the fixed-position JSONL keyed by PDB stem — see proteinmpnn for the parsing quirks. The repo ships soluble weights at v_48_010 and v_48_020 only; asking for --model_name v_48_002 --use_soluble_model errors on a missing checkpoint, so leave --model_name at its default.

Read the full file on GitHub · 88 lines

Files

What ships with it

1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 6d ago First seen · 88 lines · 96 tokens per session scan A c5c9b5cba266

Subscribe to this mod's changes

solublempnn is a skill published in the GitHub repository UnicomAI/wanwu (2,458 stars, last pushed yesterday), licensed Apache-2.0. It adds 96 tokens to every session and 1,072 once invoked, about $0.0005 per session on Opus 5. A static security scan graded it A with 0 findings. It is 100% identical to solublempnn, differing in 0 lines, and is treated as a copy.