chemgraph-agent-guide

chemgraph-agent-guide is a skill for Claude Code, Codex from wentorai/research-plugins. It costs 16 tokens per session (861 once invoked), scanned A, original, MIT.

A guide to ChemGraph, a framework that lets users control computational chemistry workflows with natural-language instructions. It connects language-model agents to tools for structure generation, geometry optimization, thermochemistry, and related calculations.

In plain words
What is it for?
Use it to optimize molecular geometries, calculate vibrational frequencies or thermochemical properties, generate structures, and run calculations with DFT, semi-empirical, or machine-learning methods.
Why use it?
It reduces the amount of custom workflow code needed to run common molecular calculations across different chemistry engines.

Skill for Claude CodeCodex

Which agent this was written for is unclear — built for openclaw. Also seen: built for openclaw.

Good fit Use it to optimize molecular geometries, calculate vibrational frequencies or thermochemical properties, generate structures, and run calculations with DFT, semi-empirical, or machine-learning methods.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/wentorai/research-plugins/chemgraph-agent-guide
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add wentorai/research-plugins --skill chemgraph-agent-guide
Clone the repo
git clone --depth 1 https://github.com/wentorai/research-plugins

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for chemgraph-agent-guide

README.md
[![agentmods](https://agentmods.dev/badge/skills/wentorai/research-plugins/chemgraph-agent-guide/github.svg)](https://agentmods.dev/skills/wentorai/research-plugins/chemgraph-agent-guide)
Your own site
<a href="https://agentmods.dev/skills/wentorai/research-plugins/chemgraph-agent-guide"><img src="https://agentmods.dev/badge/skills/wentorai/research-plugins/chemgraph-agent-guide/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for chemgraph-agent-guide

Your own site · 80×15
<a href="https://agentmods.dev/skills/wentorai/research-plugins/chemgraph-agent-guide"><img src="https://agentmods.dev/badge/skills/wentorai/research-plugins/chemgraph-agent-guide.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 16 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 861 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 2 findings, up to medium

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • medium analysis-evasion · line 1
    Suspicious Unicode normalization or mixed-script content
    Fix: Review the flagged content for security risks. Ensure no credentials, secrets, or sensitive data are exposed.
  • medium MCP Rug Pull · line 25
    Docker image references without a specific tag (:latest is implicit) or digest (@sha256:...) can be silently replaced by a malicious image.
    Fix: Pin the image: image:tag or image@sha256:abc123
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00016 $0.00861
Opus 5 $0.00008 $0.00430
Sonnet 5 $0.00003 $0.00172
Haiku 4.5 $0.00002 $0.00086

Measured 6d ago against content hash 901aced2bfb4, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-10, from the pricing page.

Security

Grade A, and why

chemgraph-agent-guide scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 6d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/domains/chemistry/chemgraph-agent-guide/SKILL.md · 121 lines

How it starts

The opening of the file, as written. The whole thing — 121 lines — stays where its author put it; the contents beside it link to each section on GitHub.

ChemGraph Agent Guide

Overview

ChemGraph is an agentic framework from Argonne National Lab that automates molecular simulation workflows using LLMs. Built on LangGraph and ASE (Atomic Simulation Environment), it enables natural language control of computational chemistry tasks — structure generation, geometry optimization, thermochemistry, and more. Supports DFT (NWChem, ORCA), semi-empirical (xTB), and ML potentials (MACE).

Installation

pip install chemgraph

# Or via Docker
docker pull ghcr.io/argonne-lcf/chemgraph:latest

Core Capabilities

Natural Language Chemistry

from chemgraph import ChemGraphAgent

agent = ChemGraphAgent(
    llm_provider="anthropic",
    calculator="xtb",  # fast semi-empirical
)

# Natural language molecular tasks
result = agent.run("Optimize the geometry of caffeine and calculate its vibrational frequencies")
print(result.energy)
print(result.frequencies)

# Thermochemistry
result = agent.run("Calculate the enthalpy of formation of ethanol at 298K")
print(f"ΔHf = {result.enthalpy:.2f} kJ/mol")

Supported Calculators

Calculator Type Speed Accuracy
xTB (TBLite) Semi-empirical Fast Moderate
MACE ML potential Fast Good
NWChem Ab initio DFT Slow High
ORCA Ab initio/DFT Slow High
UMA Universal ML Fast Good

Workflow Automation

# Multi-step workflow
workflow = agent.create_workflow([
    "Generate 3D structure of aspirin from SMILES",
    "Optimize geometry with DFT/B3LYP/6-31G*",
    "Calculate IR spectrum",
    "Identify key functional group vibrations",
])
results = workflow.execute()

# Reaction pathway
pathway = agent.run(
    "Find the transition state for the Diels-Alder reaction "
    "between butadiene and ethylene"
)

Integration with ASE

from ase.io import read
from chemgraph.calculators import get_calculator

# Use ChemGraph's calculator with ASE directly
atoms = read("molecule.xyz")
calc = get_calculator("xtb")
atoms.calc = calc

energy = atoms.get_potential_energy()
forces = atoms.get_forces()

Read the full file on GitHub · 121 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 6d ago First seen · 121 lines · 16 tokens per session scan A 901aced2bfb4

Subscribe to this mod's changes

chemgraph-agent-guide is a skill published in the GitHub repository wentorai/research-plugins (291 stars, last pushed 2mo ago), licensed MIT. It adds 16 tokens to every session and 861 once invoked, about $0.0001 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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