bioinformatics

bioinformatics is a skill for Claude Code, Codex from Zaoqu-Liu/ScienceClaw. It costs 0 tokens per session (518 once invoked), scanned A, original, MIT.

General guidance for analyzing biological and genomic data with tools chosen for the specific workflow.

In plain words
What is it for?
Use it for RNA sequencing, single-cell RNA sequencing, genetic association studies, quality control, normalization, differential expression, clustering, cell-type labeling, and pathway analysis.
Why use it?
It provides a workflow from raw measurements to quality checks, statistical comparisons, visualizations, and biological interpretation without locking the work to one package.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it for RNA sequencing, single-cell RNA sequencing, genetic association studies, quality control, normalization, differential expression, clustering, cell-type labeling, and pathway analysis.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/zaoqu-liu/scienceclaw/bioinformatics
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add Zaoqu-Liu/ScienceClaw --skill bioinformatics
Clone the repo
git clone --depth 1 https://github.com/Zaoqu-Liu/ScienceClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for bioinformatics

README.md
[![agentmods](https://agentmods.dev/badge/skills/zaoqu-liu/scienceclaw/bioinformatics.svg)](https://agentmods.dev/skills/zaoqu-liu/scienceclaw/bioinformatics)
Your own site
<a href="https://agentmods.dev/skills/zaoqu-liu/scienceclaw/bioinformatics"><img src="https://agentmods.dev/badge/skills/zaoqu-liu/scienceclaw/bioinformatics.svg" alt="Measured on agentmods" height="20"></a>
Per session 0 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 518 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00000 $0.00518
Opus 5 $0.00000 $0.00259
Sonnet 5 $0.00000 $0.00104
Haiku 4.5 $0.00000 $0.00052

Measured 8d ago against content hash f60535f6e2eb, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-07, from the pricing page.

Security

Grade A, and why

bioinformatics scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 8d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

Copies of this mod

1 near-identical copy found in the catalogue:

skills/bioinformatics/SKILL.md · 51 lines

What it actually says

Bioinformatics Analysis

Overview

Computational biology and genomics analysis pipelines. GENERAL: not locked to any specific tool — use Scanpy, Seurat, DESeq2, or any appropriate package.

Common Workflows

RNA-seq Analysis

  1. Quality control (FastQC, MultiQC)
  2. Alignment (STAR, HISAT2) or pseudo-alignment (Salmon, kallisto)
  3. Quantification (featureCounts, Salmon quant)
  4. Normalization (DESeq2 vst/rlog, edgeR TMM)
  5. Differential expression (DESeq2, edgeR, limma-voom)
  6. Visualization (volcano plot, MA plot, heatmap)
  7. Pathway analysis (clusterProfiler GO/KEGG, GSEA)

scRNA-seq Analysis (Scanpy / Seurat)

  1. Quality control (filter cells: mito%, gene count, UMI count)
  2. Normalization (library size, log1p)
  3. Feature selection (highly variable genes)
  4. Dimensionality reduction (PCA → UMAP/tSNE)
  5. Clustering (Leiden, Louvain)
  6. Marker identification (Wilcoxon, t-test)
  7. Cell type annotation (manual markers or automated)
  8. Trajectory analysis (PAGA, diffusion pseudotime)

GWAS / Genomics

  1. Quality control (MAF, HWE, call rate, relatedness)
  2. Association testing (PLINK, REGENIE)
  3. Multiple testing correction (Bonferroni, FDR)
  4. Manhattan plot, Q-Q plot
  5. Fine-mapping, colocalization

Key Databases

  • GEO (Gene Expression Omnibus): public expression datasets
  • TCGA (The Cancer Genome Atlas): cancer genomics
  • GTEx (Genotype-Tissue Expression): tissue-specific expression
  • ClinVar: clinical variant interpretations
  • UniProt: protein sequences and annotations
  • Ensembl: genome annotation

File Formats

Format Content Tools
FASTQ Raw sequencing reads FastQC, Trimmomatic
BAM/SAM Aligned reads samtools, IGV
VCF Variant calls bcftools, GATK
h5ad AnnData (scRNA-seq) Scanpy
RDS R object Seurat, DESeq2
BED Genomic regions bedtools
Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 8d ago First seen · 51 lines · 0 tokens per session scan A f60535f6e2eb

Subscribe to this mod's changes

bioinformatics is a skill published in the GitHub repository Zaoqu-Liu/ScienceClaw (60 stars, last pushed 5mo ago), licensed MIT. It costs nothing until one of its globs matches a file; then it loads 518 tokens. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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