FridrichMethod

204 mods across 1 repository, 15 stars between them.

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Generates, normalizes, and converts bedGraph signal tracks (4-column chrom/start/end/value, 0-based half-open) with bedtools genomecov, deepTools bamCoverage/bamCompare/bigwigCompare, bedtools unionbedg, and UCSC bedGraphToBigWig. Covers why a raw coverage bedGraph is not comparable across samples until normalized…

not rated 15 5d ago A 197 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Genomic interval ops on BED/BAM/GFF/VCF. Find overlaps, merge intervals, compute coverage, extract FASTA, find nearest features. Core for ChIP-seq peak annotation, region filtering, genome arithmetic. Use tabix for indexed single-region queries; use deeptools for normalized bigWig coverage.

not rated 15 changed 12d ago A 74 tokens

before-you-build

147

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Pre-build product and feature risk review for founders, product managers, and AI-assisted builders. Use this skill when the user is about to build a landing page, MVP, SaaS product, internal tool, agent workflow, or major feature and needs to check demand, positioning, monetization, retention, trust, distribution, and…

not rated 15 5d ago A 75 tokens

benchling-integration

148

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Benchling R&D Python SDK: CRUD on registry entities (DNA, RNA, proteins, custom), inventory, ELN, workflow automation. Needs Benchling account and API key. Use biopython for local sequence analysis; pubchem for chemical DBs.

not rated 15 5d ago A 57 tokens

bgpt-paper-search

149

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Searches BGPT scientific papers by topic or DOI and retrieves claim-level evidence extracted from full text, including experiments, reported statistics, scope, limitations, and provenance. Use for literature reviews, evidence synthesis, and finding experimental details beyond abstracts.

not rated 15 changed 12d ago A 53 tokens

bids

150

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Organizes, queries, validates, and converts Brain Imaging Data Structure (BIDS) datasets. Supports organizing neuroscience and biomedical data (MRI, EEG, MEG, iEEG, PET, microscopy, NIRS, motion capture, EMG, MR spectroscopy, behavioral), querying BIDS layouts, validating compliance, converting DICOM to BIDS, writing…

not rated 15 changed 12d ago A 84 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Reads, queries, and writes bigWig indexed binary signal tracks (coverage, fold-change, conservation, methylation-rate) with pyBigWig (Python) and the UCSC Kent tools (bedGraphToBigWig, bigWigToBedGraph, bigWigInfo, bigWigSummary, bigWigAverageOverBed) and deepTools (multiBigwigSummary, computeMatrix, bigwigCompare).…

not rated 15 5d ago A 211 tokens

billing-automation

152

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Build automated billing systems for recurring payments, invoicing, subscription lifecycle, and dunning management. Use when implementing subscription billing, automating invoicing, or managing recurring payment systems.

not rated 15 5d ago A 40 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Master binary analysis patterns including disassembly, decompilation, control flow analysis, and code pattern recognition. Use when analyzing executables, understanding compiled code, or performing static analysis on binaries.

not rated 15 5d ago A 43 tokens

bindcraft

154

FridrichMethod/awesome-skills

Skill Claude CodeCodex

End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high…

not rated 15 5d ago A 104 tokens

binder-design

155

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use…

not rated 15 5d ago A 91 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.

not rated 15 5d ago A 57 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use…

not rated 15 5d ago A 142 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Detects putative ligand-binding pockets and druggable cavities de novo on an apo protein structure with fpocket, P2Rank, CASTp, and DoGSiteScorer, ranking them by druggability/ligandability score. Use when detecting cavities on an apo structure with no bound ligand; choosing geometric pocket enumeration (fpocket…

not rated 15 5d ago A 236 tokens

bindingdb-database

159

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.

not rated 15 5d ago A 68 tokens

bio-admet-prediction

160

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Predicts ADMET properties using ADMETlab 3.0 API or DeepChem models. Estimates bioavailability, CYP inhibition, hERG liability, and 119 toxicity endpoints with uncertainty quantification. Filters for PAINS and other structural alerts. Use when filtering compounds for drug-likeness or prioritizing leads by predicted…

not rated 15 5d ago A 73 tokens

FridrichMethod/awesome-skills

Skill Claude Code

Filter alignments by flags, mapping quality, and regions using samtools view and pysam. Use when extracting specific reads, removing low-quality alignments, or subsetting to target regions.

not rated 15 5d ago A 44 tokens

FridrichMethod/awesome-skills

Skill Claude Code

Create and use BAI/CSI indices for BAM/CRAM files using samtools and pysam. Use when enabling random access to alignment files or fetching specific genomic regions.

not rated 15 5d ago A 41 tokens

bio-alignment-io

164

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Read, write, and convert multiple sequence alignment files using Biopython Bio.AlignIO. Supports Clustal, PHYLIP, Stockholm, FASTA, Nexus, and other alignment formats for phylogenetics and conservation analysis. Use when reading, writing, or converting alignment file formats.

not rated 15 5d ago A 64 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Parse and analyze multiple sequence alignments using Biopython. Extract sequences, identify conserved regions, analyze gaps, work with annotations, and manipulate alignment data for downstream analysis. Use when parsing or manipulating multiple sequence alignments.

not rated 15 5d ago A 52 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Calculate alignment statistics including sequence identity, conservation scores, substitution matrices, and similarity metrics. Use when comparing alignment quality, measuring sequence divergence, and analyzing evolutionary patterns.

not rated 15 5d ago A 40 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Perform pairwise sequence alignment using Biopython Bio.Align.PairwiseAligner. Use when comparing two sequences, finding optimal alignments, scoring similarity, and identifying local or global matches between DNA, RNA, or protein sequences.

not rated 15 5d ago A 52 tokens

bio-alignment-sorting

168

FridrichMethod/awesome-skills

Skill Claude Code

Sort alignment files by coordinate or read name using samtools and pysam. Use when preparing BAM files for indexing, variant calling, or paired-end analysis.

not rated 15 5d ago A 37 tokens

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