comparative-network-toxicology-shared-mechanism-reference-grounded

comparative-network-toxicology-shared-mechanism-reference-grounded is a skill for Claude Code, Codex from aipoch/medical-research-skills. It costs 131 tokens per session (3,616 once invoked), scanned A, original, MIT.

A research-planning guide for comparing two exposures, such as chemicals or medicines, that may cause the same harmful biological outcome. Network toxicology maps exposures to possible molecular targets and then examines shared and distinct mechanisms.

In plain words
What is it for?
Use it to plan comparative toxicity studies involving exposure-target prediction, disease-target overlap, biological pathway analysis, protein-interaction networks, molecular docking, and transcriptomic cross-checks.
Why use it?
It organises target collection, pathway analysis, interaction networks, and supporting evidence into one study design. This helps prevent speculative molecular explanations from being presented as established causes.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to plan comparative toxicity studies involving exposure-target prediction, disease-target overlap, biological pathway analysis, protein-interaction networks, molecular docking, and transcriptomic cross-checks.

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Install with agentmods
npx agentmods add skills/aipoch/medical-research-skills/comparative-network-toxicology-shared-mechanism-reference-grounded
About the project

Medical Research Agent Skills is a library of agent instructions for medical and biomedical research, covering evidence analysis, study protocol design, data analysis, and academic writing. Researchers use it to guide compatible coding agents through common scientific workflows. The catalogue contains many of the library's skills and commands.

aipoch/medical-research-skills · 1,860 stars · on GitHub · aipoch.com

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add aipoch/medical-research-skills --skill comparative-network-toxicology-shared-mechanism-reference-grounded
Clone the repo
git clone --depth 1 https://github.com/aipoch/medical-research-skills

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

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README.md
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Your own site
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Your own site · 80×15
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Per session 131 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,616 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00131 $0.03616
Opus 5 $0.00066 $0.01808
Sonnet 5 $0.00026 $0.00723
Haiku 4.5 $0.00013 $0.00362

Measured 9d ago against content hash 5123a19c1e1a, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

comparative-network-toxicology-shared-mechanism-reference-grounded scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

awesome-med-research-skills/Protocol Design/comparative-network-toxicology-shared-mechanism-reference-grounded/SKILL.md · 254 lines

How it starts

The opening of the file, as written. The whole thing — 254 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Source: https://github.com/aipoch/medical-research-skills

Comparative Network Toxicology Shared-Mechanism Reference-Grounded Research Planner

You are an expert comparative network-toxicology and toxic-mechanism research planner.

Task: Generate a complete, structured research design — not a literature summary, not a tool list. A real, executable study plan with four workload options and a recommended primary path.

This skill is designed for article patterns like: exposure A + exposure B definition → exposure-target prediction → toxicity / disease target retrieval → shared-vs-specific overlap decomposition → GO / KEGG enrichment → PPI network and hub prioritization → docking support → optional transcriptomic or orthogonal cross-check → conservative mechanistic synthesis. Do not mechanically copy any anchor paper; generalize the pattern into a reusable comparative network-toxicology study-design framework.

This skill must follow the same output discipline and standardization style as the conventional-non-oncology-hub-gene-research-planner baseline: explicit scope control, four mandatory workload configurations, one recommended primary plan, dependency-aware workflow logic, a mandatory reference literature pack, and a fixed self-critical risk review immediately after the literature section.


Input Validation

Valid input: [exposure A] + [exposure B] + [shared toxic phenotype] + [validation direction or emphasis] Optional additions: parent compound vs metabolite, analog pair, one-organ toxicity only, docking required, transcriptomic cross-check, AOP framing, preferred config level, stricter shared-vs-specific logic.

Examples:

  • "Parent pesticide and metabolite with hepatotoxicity, need docking and references."
  • "Two PFAS analogs plus cardiotoxicity, shared-vs-specific mechanism design."
  • "Plasticizer and oxidation product with neurotoxicity, Advanced with transcriptomic cross-check."
  • "Two related pollutants plus liver injury, publication-ready."

Read the full file on GitHub · 254 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 254 lines · 131 tokens per session scan A 5123a19c1e1a

Subscribe to this mod's changes

comparative-network-toxicology-shared-mechanism-reference-grounded is a skill published in the GitHub repository aipoch/medical-research-skills (1,860 stars, last pushed 1mo ago), licensed MIT. It adds 131 tokens to every session and 3,616 once invoked, about $0.0007 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.