alterlab-blast

alterlab-blast is a skill for Claude Code from AlterLab-IEU/AlterLab-Academic-Skills. It costs 216 tokens per session (2,691 once invoked), scanned A, original, MIT.

A command-line workflow for BLAST+, a tool that compares DNA or protein sequences to find similar sequences. It can build local search databases, run several BLAST search types, filter results by taxonomy, and produce table-formatted output.

In plain words
What is it for?
Use it to index FASTA files, search reads or proteins with blastn, blastp, blastx, or tblastn, restrict searches to selected organisms, and use DIAMOND for very large protein searches.
Why use it?
It lets you run sequence searches against local data and process the results in scripts, including when searches are too large or sensitive for a web service.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Part of the alterlab-bioinformatics plugin — 38 skills shipped together

Good fit Use it to index FASTA files, search reads or proteins with blastn, blastp, blastx, or tblastn, restrict searches to selected organisms, and use DIAMOND for very large protein searches.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/alterlab-ieu/alterlab-academic-skills/alterlab-blast
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-blast
Clone the repo
git clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills

Made for: Claude Code.

Or install alterlab-bioinformatics, the plugin that ships this one along with the rest of its 38 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for alterlab-blast

README.md
[![agentmods](https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-blast/github.svg)](https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-blast)
Your own site
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-blast"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-blast/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for alterlab-blast

Your own site · 80×15
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-blast"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-blast.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 216 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,691 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00216 $0.02691
Opus 5 $0.00108 $0.01345
Sonnet 5 $0.00043 $0.00538
Haiku 4.5 $0.00022 $0.00269

Measured 10d ago against content hash bba88cfb99bc, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-10, from the pricing page.

Security

Grade A, and why

alterlab-blast scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 10d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (scripts/parse_blast_tab.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/bioinformatics/alterlab-blast/SKILL.md · 175 lines

How it starts

The opening of the file, as written. The whole thing — 175 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Run local NCBI BLAST+ 2.17.0 searches end-to-end: build a database with makeblastdb, search it with blastn / blastp / blastx / tblastn, emit machine-parseable tabular output, and scope by taxonomy. For very large protein searches, hand off to DIAMOND blastp --ultra-sensitive (100x–10,000x the speed of BLAST, per the DIAMOND project). This is the CLI / local-database skill; it is deliberately distinct from the Biopython web API and the gget one-liner (see routing table below).

Bulk DB builds and large searches are CPU/IO-heavy and fully offline — good candidates to run on local compute rather than burning API calls.

When to Use This Skill

Use this skill when the request involves any of:

  • "BLAST these sequences", "run blastn/blastp/blastx/tblastn", "command-line BLAST"
  • "build a local BLAST database", "makeblastdb", "index this FASTA for BLAST"
  • "search my reads against a local nt/nr database", "get tabular BLAST hits I can parse"
  • "scope the BLAST search to a taxon" (-taxids / -negative_taxids)
  • "BLAST is too slow on millions of proteins" → DIAMOND blastp
  • retrieving sequences out of a BLAST DB (blastdbcmd, requires -parse_seqids)

Does NOT Trigger

Route adjacent requests to the right sibling skill instead of forcing BLAST+:

The request is really about… Route to
The web BLAST API (Bio.Blast.NCBIWWW.qblast), or scripting BLAST inside a Python pipeline with Bio.Blast parsing alterlab-biopython
A quick one-liner BLAST/database lookup (gget blast, gene/structure/enrichment lookups) alterlab-gget
Unified programmatic access to many bio web services (UniProt, KEGG, Ensembl REST, NCBI eUtils) alterlab-bioservices
Building/searching a phylogenetic tree from sequences, not a similarity search alterlab-phylogenetics
Read alignment to a reference genome (BWA/minimap2 → BAM) and SAM/BAM handling alterlab-pysam
FASTQ→VCF variant calling pipeline alterlab-nf-core-sarek
Transcript-level RNA-seq quantification (salmon/kallisto) alterlab-rnaseq-quant
16S/ITS amplicon classification (QIIME 2) alterlab-qiime2-amplicon
Protein structure prediction / embeddings (ESM, AlphaFold) alterlab-esm

Read the full file on GitHub · 175 lines

Files

What ships with it

4 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 10d ago First seen · 175 lines · 216 tokens per session scan A bba88cfb99bc

Subscribe to this mod's changes

alterlab-blast is a skill published in the GitHub repository AlterLab-IEU/AlterLab-Academic-Skills (66 stars, last pushed 5d ago), licensed MIT. It adds 216 tokens to every session and 2,691 once invoked, about $0.0011 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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