alterlab-chai

alterlab-chai is a skill for Claude Code from AlterLab-IEU/AlterLab-Academic-Skills. It costs 160 tokens per session (1,118 once invoked), scanned A, original, MIT.

A tool for predicting the 3D shape of mixed biological assemblies, such as proteins combined with antibodies, small molecules, or DNA and RNA. Chai-1 is an open model similar in approach to AlphaFold3.

In plain words
What is it for?
It is for predicting antibody–antigen and protein–ligand structures, folding mixed assemblies from a typed FASTA file, and using optional sequence searches or structural restraints.
Why use it?
It helps researchers study how several biological components may fit together when a single protein model is not enough.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Part of the alterlab-bioinformatics plugin — 38 skills shipped together

Good fit It is for predicting antibody–antigen and protein–ligand structures, folding mixed assemblies from a typed FASTA file, and using optional sequence searches or structural restraints.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/alterlab-ieu/alterlab-academic-skills/alterlab-chai
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-chai
Clone the repo
git clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills

Made for: Claude Code.

Or install alterlab-bioinformatics, the plugin that ships this one along with the rest of its 38 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for alterlab-chai

README.md
[![agentmods](https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-chai/github.svg)](https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-chai)
Your own site
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-chai"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-chai/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for alterlab-chai

Your own site · 80×15
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-chai"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-chai.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 160 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,118 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00160 $0.01118
Opus 5 $0.00080 $0.00559
Sonnet 5 $0.00032 $0.00224
Haiku 4.5 $0.00016 $0.00112

Measured 12d ago against content hash 1615d9f80bdf, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

alterlab-chai scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 12d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/bioinformatics/alterlab-chai/SKILL.md · 92 lines

How it starts

The opening of the file, as written. The whole thing — 92 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Chai-1 (open complex prediction)

Overview

Chai-1 (Chai Discovery 2024; chaidiscovery/chai-lab) is an open AlphaFold3-style model that predicts multi-entity biomolecular complexes — proteins, small-molecule ligands, and nucleic acids together — from a single typed FASTA. It is particularly used for antibody–antigen and protein–ligand complexes, can run with or without MSAs, and accepts restraints to guide the prediction.

Its niche relative to the other folders: one FASTA describing a mixed assembly, and antibody–antigen in particular. For a ligand co-fold where you specifically want a binding affinity, use alterlab-boltz; for a bare protein, use alterlab-alphafold.

When to Use This Skill

Use this skill when the user wants to:

  • Predict an antibody–antigen complex structure.
  • Fold a mixed assembly (protein + ligand + nucleic acid) described in one FASTA.
  • Run complex prediction with or without MSAs, optionally guided by restraints.
  • Get an open AlphaFold3-style complex prediction with per-entity confidence.

Does NOT Trigger

Scenario Use instead
Predict a protein–ligand binding affinity alterlab-boltz
Protein-only or protein–protein folding alterlab-alphafold
Dock a ligand into a fixed receptor structure alterlab-diffdock
Look up an experimental complex structure alterlab-pdb
Design antibody/interface sequences alterlab-proteinmpnn / alterlab-ligandmpnn

Core Capabilities

1. Single-FASTA multi-entity input

Chai-1 reads one FASTA whose records are typed by entity. A protein + ligand example:

>protein|antibody-Fv
EVQ...SS
>protein|antigen
MKT...GG
>ligand|cofactor
CC(=O)Oc1ccccc1C(=O)O
# CLI form (verify against installed chai-lab — TODO(verify))
chai-lab fold input.fasta out/

The header type tags (protein, ligand, rna, dna) tell Chai how to treat each record; confirm the exact header/type syntax against your installed version.

Read the full file on GitHub · 92 lines

Files

What ships with it

2 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 12d ago First seen · 92 lines · 160 tokens per session scan A 1615d9f80bdf

Subscribe to this mod's changes

alterlab-chai is a skill published in the GitHub repository AlterLab-IEU/AlterLab-Academic-Skills (66 stars, last pushed 7d ago), licensed MIT. It adds 160 tokens to every session and 1,118 once invoked, about $0.0008 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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