alterlab-datamol

alterlab-datamol is a skill for Claude Code from AlterLab-IEU/AlterLab-Academic-Skills. It costs 120 tokens per session (3,482 once invoked), scanned A, original, MIT.

A Python-friendly interface for RDKit, a toolkit for working with chemical molecules, through Datamol. It loads common molecule files, cleans structures, calculates properties, and supports grouping, 3D shapes, and batch work.

In plain words
What is it for?
Use it to convert molecule formats, standardize structures, calculate descriptors and fingerprints, create 3D conformers, cluster compounds, analyze scaffolds, and process batches.
Why use it?
It gives everyday drug-discovery tasks a consistent way to process molecule data without repeatedly assembling low-level RDKit operations.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Part of the alterlab-cheminformatics plugin — 12 skills shipped together

Good fit Use it to convert molecule formats, standardize structures, calculate descriptors and fingerprints, create 3D conformers, cluster compounds, analyze scaffolds, and process batches.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/alterlab-ieu/alterlab-academic-skills/alterlab-datamol
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-datamol
Clone the repo
git clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills

Made for: Claude Code.

Or install alterlab-cheminformatics, the plugin that ships this one along with the rest of its 12 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for alterlab-datamol

README.md
[![agentmods](https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-datamol/github.svg)](https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-datamol)
Your own site
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-datamol"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-datamol/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for alterlab-datamol

Your own site · 80×15
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-datamol"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-datamol.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 120 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,482 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00120 $0.03482
Opus 5 $0.00060 $0.01741
Sonnet 5 $0.00024 $0.00696
Haiku 4.5 $0.00012 $0.00348

Measured 10d ago against content hash b638449b51c7, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-10, from the pricing page.

Security

Grade A, and why

alterlab-datamol scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 10d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/cheminformatics/alterlab-datamol/SKILL.md · 318 lines

How it starts

The opening of the file, as written. The whole thing — 318 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Datamol Cheminformatics Skill

Overview

Datamol is a Python library that provides a lightweight, Pythonic abstraction layer over RDKit for molecular cheminformatics. Simplify complex molecular operations with sensible defaults, efficient parallelization, and modern I/O capabilities. All molecular objects are native rdkit.Chem.Mol instances, ensuring full compatibility with the RDKit ecosystem.

Key capabilities:

  • Molecular format conversion (SMILES, SELFIES, InChI)
  • Structure standardization and sanitization
  • Molecular descriptors and fingerprints
  • 3D conformer generation and analysis
  • Clustering and diversity selection
  • Scaffold and fragment analysis
  • Chemical reaction application
  • Visualization and alignment
  • Batch processing with parallelization
  • Cloud storage support via fsspec

Installation and Setup

Guide users to install datamol:

uv pip install datamol

Examples here are verified against datamol 0.12.x (pulls in RDKit automatically). The descriptor key names below are stable in this line; pin if you depend on them: uv pip install 'datamol>=0.12,<0.13'.

Import convention:

import datamol as dm

Core Workflows

Each subsection below shows the primary call pattern. Full API signatures, parameters, and secondary examples live in the per-module reference files cited under each; complete multi-step pipelines live in references/workflow_recipes.md.

1. Basic Molecule Handling

import datamol as dm

# Parse SMILES (returns None on failure)
mol = dm.to_mol("CCO")                        # Ethanol
mols = [dm.to_mol(smi) for smi in ["CCO", "c1ccccc1", "CC(=O)O"]]
if dm.to_mol("invalid_smiles") is None:
    print("Failed to parse SMILES")

# Export to common formats (canonical + isomeric by default)
smiles   = dm.to_smiles(mol)                  # keeps stereochemistry
flat     = dm.to_smiles(mol, isomeric=False)  # drops stereochemistry
inchi    = dm.to_inchi(mol)
inchikey = dm.to_inchikey(mol)
selfies  = dm.to_selfies(mol)

# Standardize user-provided molecules (recommended for datasets)
mol = dm.sanitize_mol(mol)
mol = dm.standardize_mol(mol, disconnect_metals=True, normalize=True, reionize=True)
clean_smiles = dm.standardize_smiles(smiles)

Read the full file on GitHub · 318 lines

Files

What ships with it

8 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 10d ago First seen · 318 lines · 120 tokens per session scan A b638449b51c7

Subscribe to this mod's changes

alterlab-datamol is a skill published in the GitHub repository AlterLab-IEU/AlterLab-Academic-Skills (66 stars, last pushed 5d ago), licensed MIT. It adds 120 tokens to every session and 3,482 once invoked, about $0.0006 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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